Abstract: The formation method was revealed of a bacteriophage synergistic composition intended to prevent and combat infections of livestock, including but not limited to poultry, with pathogenic bacteria strains sensitive to the phages.

Abstract: A rapid method has been disclosed that allows for the unequivocal identification of extraintestinal E. coli strains pathogenic for poultry using a new combination of genes amplified in a multiplex PCR diagnostic method.

Abstract: New strains of bacteriophages and their applications are revealed, useful especially in fish farming.

Abstract: New strains of bacteriophages and their applications are revealed, useful especially in fish farming.

Abstract: Method of inhibiting the growth of Salmonella in a chicken, comprising administering at least one strain of bacteriophage that lyses at least one Salmonella serovar to a chicken in need thereof, wherein the at least one strain of bacteriophage is a strain selected from PCM F/00069 (strain 8sent1748), PCM F/00070 (strain 8sent65) and PCM F/00071 (strain 3sent1).

Abstract: A substituted chroman compound includes R1a and R1b as substituents selected from hydrogen and phenyl optionally substituted with 1-3 substituents. R2a and R2b are hydrogen atoms. R3a and R3b are C1-C4 alkyls, or represent an oxo group, or are C5-C8 alkylene substituents. R3a and R3b with their attached carbon atom form a ring. Nitrogen atoms replace two non-adjacent carbon atoms in the main chain to the C5-8 alkylene, which is optionally substituted by a thioxo group. n is the number of the substituents Rz. z is the sequence number of the substituent Rz. (Rz) is a substituent on the benzene ring attached to a non-nodal carbon atom selected from hydroxyl, halogen, C2-C6 alkenyl, C1-C4 alkoxy, C1-4 alkanoyloxy, heterocyclic C4-C7 alkyloxy having an oxygen atom in the ring and optionally substituted with 1-3 substituents. The compound is used as a tautomer, enantiomer, diastereomer, mixture of enantiomers and/or mixture of diastereomers.

Abstract: A method for obtaining a strain of bacteriophage specific to a selected strain of bacteria was found as well as bacteriophage strains obtained in this way. Moreover, application of bacteriophages in manufacturing of the preparation for preventing and fighting infections of farm animals, especially poultry, with pathogenic strains of bacteria sensitive to these phages was described.

Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumor cells.

Abstract: A method for obtaining a strain of bacteriophage specific to a selected strain of bacteria was found as well as bacteriophage strains obtained in this way. Moreover, application of bacteriophages in manufacturing of the preparation for preventing and fighting infections of farm animals, especially poultry, with pathogenic strains of bacteria sensitive to these phages was described.

Abstract: The subject of the present invention is a method of modifying proteinaceous toxins through the addition of an NLS motif. The resulting cytotoxin facilitates the selective elimination of proliferating cells, particularly tumour cells.

Abstract: A method is described for the characterization of a tested substance, particularly useful in the study of its toxicity, and in particular immunotoxicity. Also described are cell lines and nucleic acids useful in its procurement, which may be used to embody said method, particularly in obtaining cell-chip collections destined for immunotoxicity assays.

Abstract: Immune-chips, which are arrays of peptides probes are used to obtain a pattern which characterizes the global immune reactivity status of the human or other organism, are described. The peptide probes participate in immune reactions with antibodies and immune receptors of the investigated organisms to generate an immune pattern on the chip, which are detected and stored as patterns in databases. The patterns are then compared with other patterns observed with the same array and obtained under physiological, pathological and experimental conditions from the same or other organisms. The comparison is used to classify the state of the investigated organisms based on similarity to other observed states. The immune chips and the obtained patterns can be used for clinical diagnosis and biological studies, such as the investigation of similarities between physiological, pathological or experimental processes.

Abstract: Immune-chips, which are arrays of peptides probes are used to obtain a pattern which characterizes the global immune reactivity status of the human or other organism, are described. The peptide probes participate in immune reactions with antibodies and immune receptors of the investigated organisms to generate an immune pattern on the chip, which are detected and stored as patterns in databases. The patterns are then compared with other patterns observed with the same array and obtained under physiological, pathological and experimental conditions from the same or other organisms. The comparison is used to classify the state of the investigated organisms based on similarity to other observed states. The immune chips and the obtained patterns can be used for clinical diagnosis and biological studies, such as the investigation of similarities between physiological, pathological or experimental processes.

Abstract: A method is described for the characterisation of a tested substance, particularly useful in the study of its toxicity, and in particular immunotoxicity. Also described are cell lines and nucleic acids useful in its procurement, which may be used to embody said method, particularly in obtaining cell-chip collections destined for immunotoxicity assays.