Patents by Inventor Jasbir Seehra

Jasbir Seehra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activin-ActRIIa antagonists and uses for treating multiple myeloma
    Patent number: 8173601
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: May 8, 2012
    Assignee: Acceleron Pharma, Inc.
    Inventors: John Knopf, Jasbir Seehra, Ravindra Kumar
  • Pharmaceutical preparations comprising an ALK1-Fc fusion protein
    Patent number: 8158584
    Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: April 17, 2012
    Assignees: Acceleron Pharma, Inc., Ludwig Institute for Cancer Research Ltd.
    Inventors: Asya Grinberg, John Knopf, Ravindra Kumar, Robert S. Pearsall, Jasbir Seehra, Kristian Pietras
  • Methods for increasing adiponectin in a patient in need thereof
    Patent number: 8138142
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: March 20, 2012
    Assignee: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Ravindra Kumar, Jennifer Lachey, Alan Koncarevic
  • METHOD FOR PROMOTING BONE GROWTH USING ACTIVIN-ACTRIIA ANTAGONISTS
    Publication number: 20120058115
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Application
    Filed: July 5, 2011
    Publication date: March 8, 2012
    Applicant: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • Method of promoting bone growth by an anti-activin B antibody
    Patent number: 8128933
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: March 6, 2012
    Assignee: Acceleron Pharma, Inc.
    Inventors: John Knopf, Jasbir Seehra
  • USE OF GDF TRAPS TO INCREASE RED BLOOD CELL LEVELS
    Publication number: 20120015877
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: September 28, 2011
    Publication date: January 19, 2012
    Applicant: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • ANTAGONISTS OF ACTRIIB AND USES FOR INCREASING RED BLOOD CELL LEVELS
    Publication number: 20120003218
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: August 25, 2011
    Publication date: January 5, 2012
    Applicant: Acceleron Pharma Inc.
    Inventors: Matthew L. Sherman, Jasbir Seehra, Niels Borgstein
  • Method for promoting bone growth using activin-ActRIIa antagonists
    Patent number: 8067360
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: November 29, 2011
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • Method of increasing red blood cell levels or treating anemia in a patient
    Patent number: 8058229
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: November 15, 2011
    Assignee: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar
  • ACTIVIN-ACTRIIA ANTAGONISTS FOR INHIBITING GERM CELL MATURATION
    Publication number: 20110218147
    Abstract: In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 8, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra, Matthew L. Sherman
  • Cerberus/coco derivatives and uses thereof
    Patent number: 7981857
    Abstract: The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11. Preferred polypeptides are Coco or Cerberus derivatives.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: July 19, 2011
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • COMPOSITIONS AND METHODS FOR INCREASING SERUM HALF-LIFE
    Publication number: 20110171218
    Abstract: Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or more non-endogenous glycosylation sites.
    Type: Application
    Filed: December 2, 2010
    Publication date: July 14, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, John Knopf, Ravindra Kumar
  • Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
    Patent number: 7960343
    Abstract: In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: June 14, 2011
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra, Matthew L. Sherman
  • ACTRIIB PROTEINS AND VARIANTS AND USES THEREFORE RELATING TO UTROPHIN INDUCTION FOR MUSCULAR DYSTROPHY THERAPY
    Publication number: 20110135638
    Abstract: In certain aspects, the present invention provides compositions and methods for inducing utrophin expression in muscle with an ActRIIB protein as therapy for muscular dystrophy. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Application
    Filed: November 17, 2010
    Publication date: June 9, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Jennifer Lachey
  • METHODS FOR TREATING FATTY LIVER DISEASE
    Publication number: 20110129469
    Abstract: In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies and anti-activin A or B antibodies. A variety of hepatic and metabolic disorders may be improved by treating fatty liver disease.
    Type: Application
    Filed: November 3, 2010
    Publication date: June 2, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: Alan Koncarevic, Jennifer Lachey, Jasbir Seehra, Matthew L. Sherman
  • Activin-ActRIIa antagonists and uses for promoting bone growth
    Patent number: 7951771
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: May 31, 2011
    Assignee: Acceleron Pharma Inc.
    Inventors: John Knopf, Jasbir Seehra
  • VARIANTS DERIVED FROM ACTRIIB AND USES THEREFOR
    Publication number: 20110092670
    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
    Type: Application
    Filed: September 29, 2010
    Publication date: April 21, 2011
    Applicant: ACCELERON PHARMA INC.
    Inventors: JOHN KNOPF, JASBIR SEEHRA, RAVINDRA KUMAR
  • ACTRIIB ANTAGONISTS AND DOSING AND USES THEREOF
    Publication number: 20110070233
    Abstract: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist are also provided.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 24, 2011
    Applicant: ACCELERON PHARMA INC.
    Inventors: JASBIR SEEHRA, JOHN KNOPF, Kenneth M. ATTIE
  • USES OF CERBERUS AND DERIVATIVES THEREOF
    Publication number: 20110046057
    Abstract: The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
    Type: Application
    Filed: November 5, 2010
    Publication date: February 24, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: Asya Grinberg, John Knopf, Ravindra Kumar, Jasbir Seehra
  • COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE RED BLOOD CELL LEVELS
    Publication number: 20110038831
    Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
    Type: Application
    Filed: August 13, 2010
    Publication date: February 17, 2011
    Applicant: Acceleron Pharma Inc.
    Inventors: Jasbir Seehra, Robert Scott Pearsall, Ravindra Kumar