Patents by Inventor Jashim Uddin

Jashim Uddin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and method for imaging cancer
    Patent number: 10792377
    Abstract: A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: October 6, 2020
    Assignee: Vanderbilt University
    Inventors: Jashim Uddin, Brenda C. Crews, Lawrence J. Marnett
  • Composition and method for detecting hypoxia
    Patent number: 10695446
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett
  • Fluorocoxib A loading into ROS-responsive nanoparticles
    Patent number: 10105455
    Abstract: Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a NSAID drug; and a ROS-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: October 23, 2018
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Lawrence J. Marnett, Jashim Uddin, Thomas A. Werfel, Mukesh Gupta, Brenda C. Crews
  • Compounds and Method for Imaging Cancer
    Publication number: 20180280543
    Abstract: A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.
    Type: Application
    Filed: April 3, 2018
    Publication date: October 4, 2018
    Inventors: Jashim Uddin, Brenda C. Crews, Lawrence J. Marnett
  • Composition and Method for Detecting Hypoxia
    Publication number: 20180085475
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Application
    Filed: May 2, 2016
    Publication date: March 29, 2018
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett
  • FLUOROCOXIB A LOADING INTO ROS-RESPONSIVE NANOPARTICLES
    Publication number: 20170007723
    Abstract: Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a NSAID drug; and a ROS-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.
    Type: Application
    Filed: July 11, 2016
    Publication date: January 12, 2017
    Inventors: Craig L. Duvall, Lawrence J. Marnett, Jashim Uddin, Thomas A. Werfel, Mukesh Gupta, Brenda C. Crews