Abstract: Various compositions and diagnostic devices for the detection of nucleic acids are provided. Also provided are systems comprising the same, and methods of using the same. In some embodiments, compositions and devices comprise or are configured to be used in combination with one or more of a guide nucleic acid, a programmable nuclease, and reporters. In some embodiments, presence of at least one sequence of interest is determined by detecting a signal produced upon cleavage of the reporters.

Abstract: Integrated circuits and integrated circuit dies include TSVs laid out in symmetrical patterns. Because of the symmetrical arrangement of the TSVs and associated routing patterns, an integrated circuit is able to support operation of multiple similar dies that are placed in different positions in the integrated circuit. This in turn simplifies the design and production of the multiple similar dies, thus reducing development and manufacturing costs for the corresponding integrated circuits.

Abstract: A method and system may be implemented for automatically analyzing data in a database. A method for use in a low-latency database analysis system may include generating a schema. The schema may be based on a portion of an external database. The method may include storing the schema in an in-memory database. The method may include receiving a data-query. The method may include generating a resolved-request. The resolved-request may be based on the data-query and the stored schema. The stored schema may be used for executing the query on the external database. The method may include receiving results data responsive to the data-query from the external database. The method may include outputting the results data for display on a user interface.

Abstract: A system with a processor configured to execute a front-end variable determination program including steps to receive determination data indicative of previous events; to identify, utilizing a multiple variable statistical algorithm, data brackets, each having interpolated correlation with indications of the previous events; to identify, utilizing bivariate analysis and the data brackets, a determined variable defining a strong interpolated correlation with indications of the previous events; and to generate, utilizing bivariate analysis, an associated determined value that separates ranges of data associated with the determined variable based on the strong interpolated correlation within the determination data.

Abstract: A method for generating an extrapolated indication includes receiving input data associated with a subsequent event and indicating a determined variable for the subsequent event. The determined variable is strongly correlated with indications of previous events and is identified utilizing bivariate analysis and data brackets correlated with the indications of the previous events, as identified using a multiple variable algorithm and the previous events. The method also includes generating the extrapolated indication associated with the subsequent event utilizing the input data, the determined variable, and an associated determined value, which separates ranges of data associated with the determined variable, which is strongly correlated with indications of the previous events and is generated utilizing bivariate analysis and the data brackets.

Abstract: A system with a processor configured to perform steps including receive determination data indicative of previous events associated with users and to identify, utilizing a multiple variable statistical algorithm, data brackets, each having interpolated correlation with indications of the previous events. Further steps include to identify, utilizing bivariate analysis and the data brackets, a determined variable defining a strong interpolated correlation with indications of the previous events and to generate, utilizing bivariate analysis, an associated determined value that separates ranges of data associated with the determined variable based on the strong interpolated correlation within the determination data.

Abstract: A system for detecting wear in an encoder used to sense a wheel speed in a vehicle comprises a sensor configured to sense the wheel speed of the vehicle by sensing a magnetic material on the encoder coupled to a wheel of the vehicle. A noise detection module includes a plurality of noise detectors configured to detect noise in a wheel speed signal generated by the sensor. An estimation module is configured to estimate a state of health of the encoder based on the noise detected in the wheel speed signal and to generate an alert in response to the state of health indicating that an amount of wear on the encoder is greater than a predetermined threshold. A filter is configured to filter the noise in the wheel speed signal and to output a filtered wheel speed signal to a control system controlling stability of the vehicle.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: In an approach for training data enhancement for an interactive response system, a processor retrieves a set of training data including a set of intents, a set of entities, and a set of utterances that map to each intent. A processor determines iteratively a root verb among the set of utterances for each intent. A processor to determine a set of new intents based on analysis of the determined root verb by performing a pairwise iteration and similarity score over the set of intents. A processor determines iteratively one or more new entities for each new intent. A processor generates a set of new training data based on the set of new intents and entities.

Abstract: Automatic database analysis includes identifying a current context for accessing data from a low-latency database and generating an exploration query based on the current context, which includes identifying a column from the low-latency database as a column of utility in response to determining that a probabilistic utility for the column satisfies a defined utility criterion. The current context includes a requested result set satisfying a requested search criterion, and the probabilistic utility is based on the current context. The analysis includes generating an exploration result set based on the exploration query, generating insights based on the exploration result set, ranking the insights, and outputting at least one insight based on the ranking.

Abstract: Integrated circuits and integrated circuit dies include TSVs laid out in symmetrical patterns. Because of the symmetrical arrangement of the TSVs and associated routing patterns, an integrated circuit is able to support operation of multiple similar dies that are placed in different positions in the integrated circuit. This in turn simplifies the design and production of the multiple similar dies, thus reducing development and manufacturing costs for the corresponding integrated circuits.

Abstract: A method and system may be implemented for automatically analyzing data in a database. A method for use in a low-latency database analysis system may include generating a schema. The schema may be based on a portion of an external database. The method may include storing the schema in an in-memory database. The method may include receiving a data-query. The method may include generating a resolved-request. The resolved-request may be based on the data-query and the stored schema. The stored schema may be used for executing the query on the external database. The method may include receiving results data responsive to the data-query from the external database. The method may include outputting the results data for display on a user interface.

Abstract: A method and system may be implemented for automatically analyzing data in a database. A method for use in a low-latency database analysis system may include generating a schema. The schema may be based on a portion of an external database. The method may include storing the schema in an in-memory database. The method may include receiving a data-query. The method may include generating a resolved-request. The resolved-request may be based on the data-query and the stored schema. The stored schema may be used for executing the query on the external database. The method may include receiving results data responsive to the data-query from the external database. The method may include outputting the results data for display on a user interface.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: A system for detecting wear in an encoder used to sense a wheel speed in a vehicle comprises a sensor configured to sense the wheel speed of the vehicle by sensing a magnetic material on the encoder coupled to a wheel of the vehicle. A noise detection module includes a plurality of noise detectors configured to detect noise in a wheel speed signal generated by the sensor. An estimation module is configured to estimate a state of health of the encoder based on the noise detected in the wheel speed signal and to generate an alert in response to the state of health indicating that an amount of wear on the encoder is greater than a predetermined threshold. A filter is configured to filter the noise in the wheel speed signal and to output a filtered wheel speed signal to a control system controlling stability of the vehicle.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids.

Abstract: Embodiments include a method, system and computer program product for detecting impersonation attempts in social media messaging. Aspects include receiving, via a social media network, a message from a sender to a recipient and analyzing a content of the message to extract factual statements from the message. Aspects also include analyzing a profile of the recipient to extract facts from the profile and comparing each of the factual statements to the facts from the profile. Based on a determination that one of the factual statements are verifiable by at least one of the facts, aspects include assigning a likelihood score to the factual statements. Aspects further include calculating a legitimacy score for the message based at least in part on the likelihood score of each verified factual statement from the message and transmitting the legitimacy score and the message to the recipient.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: In an approach for training data enhancement for an interactive response system, a processor retrieves a set of training data including a set of intents, a set of entities, and a set of utterances that map to each intent. A processor determines iteratively a root verb among the set of utterances for each intent. A processor to determine a set of new intents based on analysis of the determined root verb by performing a pairwise iteration and similarity score over the set of intents. A processor determines iteratively one or more new entities for each new intent. A processor generates a set of new training data based on the set of new intents and entities.