Abstract: Mechanisms are provided for enhancing artificial intelligence computer model response generation. The mechanisms receive an input request from a client computing device and identify first field(s) of a data dictionary of a data source schema for inclusion in an initial set of fields having direct matches to elements of the input request. The mechanisms, for each first field, analyze second fields, adjacent to the one or more first fields, in the data dictionary, to identify a set of relevant second fields which are added to the initial field listing to generate an expanded field listing. A prompt to a generative artificial intelligence (AI) computer model is generated comprising a context portion populated with data for the first fields and relevant second fields. The prompt is processed by the AI computer model to generate a response based on the context portion of the prompt.

Abstract: Various compositions and diagnostic devices for the detection of nucleic acids are provided. Also provided are systems comprising the same, and methods of using the same. In some embodiments, compositions and devices comprise or are configured to be used in combination with one or more of a guide nucleic acid, a programmable nuclease, and reporters. In some embodiments, presence of at least one sequence of interest is determined by detecting a signal produced upon cleavage of the reporters.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: In an approach for training data enhancement for an interactive response system, a processor retrieves a set of training data including a set of intents, a set of entities, and a set of utterances that map to each intent. A processor determines iteratively a root verb among the set of utterances for each intent. A processor to determine a set of new intents based on analysis of the determined root verb by performing a pairwise iteration and similarity score over the set of intents. A processor determines iteratively one or more new entities for each new intent. A processor generates a set of new training data based on the set of new intents and entities.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids.

Abstract: Embodiments include a method, system and computer program product for detecting impersonation attempts in social media messaging. Aspects include receiving, via a social media network, a message from a sender to a recipient and analyzing a content of the message to extract factual statements from the message. Aspects also include analyzing a profile of the recipient to extract facts from the profile and comparing each of the factual statements to the facts from the profile. Based on a determination that one of the factual statements are verifiable by at least one of the facts, aspects include assigning a likelihood score to the factual statements. Aspects further include calculating a legitimacy score for the message based at least in part on the likelihood score of each verified factual statement from the message and transmitting the legitimacy score and the message to the recipient.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: In an approach for training data enhancement for an interactive response system, a processor retrieves a set of training data including a set of intents, a set of entities, and a set of utterances that map to each intent. A processor determines iteratively a root verb among the set of utterances for each intent. A processor to determine a set of new intents based on analysis of the determined root verb by performing a pairwise iteration and similarity score over the set of intents. A processor determines iteratively one or more new entities for each new intent. A processor generates a set of new training data based on the set of new intents and entities.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: Examples described herein provide for a technique for metal track routing with buffer bank insertion in a representation of a hardware design of an integrated circuit. In an example, pins of ports of hardblocks in a placed layout are identified. Logical tracks for nets associated with the pins of the ports are generated and assigned to respective metal layers. Logical tracks and corresponding nets are grouped into respective groups. Buffer bank(s) is inserted into the placed layout. Each buffer bank is for a group of logical tracks and divides each logical track and net of the group of logical tracks. Each buffer bank has pins associated with the respective divided nets. Each pin of the buffer bank(s) is assigned to a middle or higher metal layer. Metal tracks are generated in a representation of a hardware layout based on the logical tracks and pins of the ports and buffer bank(s).

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Described herein are devices, systems, fluidic devices, kits, and methods for detection of target nucleic acids associated with diseases, cancers, genetic disorders, a genotype, a phenotype, or ancestral origin. The devices, systems, fluidic devices, kits, and methods may comprise reagents of a guide nucleic acid targeting a target nucleic acid, a programmable nuclease, and a single stranded detector nucleic acid with a detection moiety. The target nucleic acid of interest may be indicative of a disease, and the disease may be communicable diseases, or of a cancer or genetic disorder. The target nucleic acid of interest may be indicative of a genotype, a phenotype, or ancestral origin.

Abstract: Embodiments include a method, system and computer program product for detecting impersonation attempts in social media messaging. Aspects include receiving, via a social media network, a message from a sender to a recipient and analyzing a content of the message to extract factual statements from the message. Aspects also include analyzing a profile of the recipient to extract facts from the profile and comparing each of the factual statements to the facts from the profile. Based on a determination that one of the factual statements are verifiable by at least one of the facts, aspects include assigning a likelihood score to the factual statements. Aspects further include calculating a legitimacy score for the message based at least in part on the likelihood score of each verified factual statement from the message and transmitting the legitimacy score and the message to the recipient.

Abstract: Disclosed herein are compositions, kits, and methods related to improved Cas activity. Through compositions and kits disclosed herein and practice of methods disclosed herein, one attains improved Cas activity such as Cas12 activity relative to Cas proteins in the art such as LbCas12. Further described herein are methods to detect target nucleic acid using a programmable nuclease system. Often, the target nucleic acids are present in at low frequency in the sample. Provided herein are methods for enriching these target nucleic acids for detection. Also described herein are methods to insert a PAM sequence into a target sequence of interest for use in a detection comprising a programmable nuclease.

Abstract: A method, computer system, and computer program product for chat protection. The embodiment may include receiving, in a chat session, a user-spoken communication and one or more inputs specific to a software program. The embodiment may also include predicting a next communication by the user based on the received user spoken communication and the one or more inputs. The embodiment may further include, in response to the predicted next communication containing untoward content, performing a remedial action.

Abstract: A method, computer system, and computer program product for chat protection. The embodiment may include receiving, in a chat session, a user-spoken communication and one or more inputs specific to a software program. The embodiment may also include predicting a next communication by the user based on the received user spoken communication and the one or more inputs. The embodiment may further include, in response to the predicted next communication containing untoward content, performing a remedial action.