Patents by Inventor Jason A. A. West
Jason A. A. West has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11935625Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.Type: GrantFiled: November 19, 2020Date of Patent: March 19, 2024Assignee: PERSONALIS, INC.Inventors: Jason Harris, Mark R. Pratt, John West, Richard Chen, Ming Li
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Publication number: 20230392875Abstract: Some embodiments include a thermal ground plane comprising a first casing layer and a second casing layer where the outer periphery of the first casing layer and the outer periphery of the second casing layer are bonded to each other. The thermal ground plane including a working fluid disposed within the first casing layer and the second casing layer. The thermal ground plane may also include a permeable wick disposed between the first casing layer and the second casing layer; and a deformed mesh disposed between the first casing layer and the permeable wick, the deformed mesh comprising a mesh with deformed mesh portions that form vapor channels and nondeformed mesh portions that form liquid channels.Type: ApplicationFiled: August 22, 2023Publication date: December 7, 2023Inventors: Ryan Lewis, Jason West, Kyle Wagner, Dylan McNally, Keller Lofgren
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Publication number: 20230381425Abstract: Provided herein are methods for providing a therapeutic benefit to a patient. A method of treating a patient with a metabolic disease and/or a pancreatic disease includes: selecting a patient with a metabolic disease and/or a pancreatic disease; selecting one or more pancreatic deposit sites; advancing a depositing device comprising a at least one depositing element to the selected one or more pancreatic deposit sites; and delivering a treatment agent through the at least one depositing element into the selected one or more pancreatic deposit sites. Systems and devices are also described.Type: ApplicationFiled: August 8, 2023Publication date: November 30, 2023Applicant: FractyI Health, Inc.Inventors: Harith Rajagopalan, Jay Caplan, Jason West, Jacob Wainer, Michael Biasella, J. Christopher Flaherty
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Publication number: 20230022146Abstract: The disclosure features methods of correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclosure also features compositions for use in the methods.Type: ApplicationFiled: June 17, 2020Publication date: January 26, 2023Inventors: Sanjay D'SOUZA, Jason WEST, Brenda K. EUSTACE, Sudipta MAHAJAN
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Publication number: 20220228142Abstract: The disclosure features systems and methods for correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclosure also features compositions for use in the methods.Type: ApplicationFiled: December 17, 2021Publication date: July 21, 2022Inventors: Sanjay D'SOUZA, Jason WEST, Brenda K. EUSTACE, Sudipta MAHAJAN
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Publication number: 20210293488Abstract: Some embodiments include a thermal ground plane comprising a first casing layer and a second casing layer where the outer periphery of the first casing layer and the outer periphery of the second casing layer are bonded to each other. The thermal ground plane including a working fluid disposed within the first casing layer and the second casing layer. The thermal ground plane may also include a permeable wick disposed between the first casing layer and the second casing layer; and a deformed mesh disposed between the first casing layer and the permeable wick, the deformed mesh comprising a mesh with deformed mesh portions that form vapor channels and nondeformed mesh portions that form liquid channels.Type: ApplicationFiled: May 1, 2020Publication date: September 23, 2021Inventors: Ryan Lewis, Jason West, Kyle Wagner, Dylan McNally, Keller Lofgren
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Patent number: 10954560Abstract: Described herein are cell-based analytic methods, including a method of incorporating nucleic acid sequences into reaction products from a cell population, wherein the nucleic acid sequences are incorporated into the reaction products of each cell individually or in small groups of cells individually. Also described herein is a matrix-type microfluidic device that permits at least two reagents to be delivered separately to each cell or group of cells, as well as primer combinations useful in the method and device.Type: GrantFiled: December 10, 2018Date of Patent: March 23, 2021Assignee: FLUIDIGM CORPORATIONInventors: Carolyn G. Conant, Tze Howe Charn, Jason A. A. West, Xiaohui Wang
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Publication number: 20210008161Abstract: The disclosure features methods of increasing repair of a DNA double stranded break (DSB) in a target gene by the homology-directed repair (HDR) pathway. The disclosure also features compositions for use in the methods.Type: ApplicationFiled: June 17, 2020Publication date: January 14, 2021Inventors: Sanjay D'Souza, Jason West
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Publication number: 20200264205Abstract: Methods for cell analysis are provided, comprising cell capturing, characterization, transport, and culture. In an exemplary method individual cells (and/or cellular units) are flowed into a microfluidic channel, the channel is partitioned into a plurality of contiguous segments, capturing at least one cell in at least one segment. A characteristic of one or more captured cells is determined and the cell(s) and combinations of cells are transported to specified cell holding chamber(s) based on the determined characteristic(s). Also provided are devices and systems for cell analysis.Type: ApplicationFiled: January 24, 2020Publication date: August 20, 2020Applicant: Fluidigm CorporationInventors: Jason A. A. West, Brian Fowler
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Patent number: 10578633Abstract: Methods for cell analysis are provided, comprising cell capturing, characterization, transport, and culture. In an exemplary method individual cells (and/or cellular units) are flowed into a microfluidic channel, the channel is partitioned into a plurality of contiguous segments, capturing at least one cell in at least one segment, A characteristic of one or more captured cells is determined and the cell(s) and combinations of cells are transported to specified cell holding chamber(s) based on the determined characteristic(s). Also provided are devices and systems for cell analysis.Type: GrantFiled: March 14, 2014Date of Patent: March 3, 2020Assignee: FLUIDIGM CORPORATIONInventors: Jason A. A. West, Brian Fowler
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Publication number: 20190363611Abstract: Techniques are disclosed for dynamically configured portable power generation. A first motion of a first pull cord mechanically coupled to a first pull-cord generator is sensed, wherein the first pull cord is also mechanically coupled to a limb of a human body. A first tension-control signal is determined as a function of the first motion. The first-tension control signal is transmitted to a first variable tensioner configured to control a tension in the first pull cord. A tension in the first pull cord is set using one or more processors based on the first tension-control signal. Electrical power is generated using the first pull-cord generator, and power generation resulting from the generating electrical power is determined. Feedback is generated to set a tension based on the determined power generation.Type: ApplicationFiled: May 24, 2019Publication date: November 28, 2019Applicant: Power Scavengers, LLCInventors: Skylar Kirkwood Bagdon, George Thomas Philbrick, Adam Christopher Hookway, Jason West Kittell
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Publication number: 20190262831Abstract: Provided are devices and methods for capturing template sample nucleic acids in a spatially specific manner that is coordinated with the original location of the templates in a tissue sample. By preserving spatial information regarding a given sample, the disclosed technology allows for improved diagnostics as well as improved therapeutic decision making for patient care and therapy.Type: ApplicationFiled: October 17, 2017Publication date: August 29, 2019Inventors: Jason A.A. WEST, Kyle HUKARI
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Publication number: 20190249238Abstract: This disclosure provides a method of forming tagged nucleic acid sequences. A target polynucleotide is immobilized on a solid support; a recognition-oligonucleotide is hybridized thereto; the recognition-oligonucleotide-target polynucleotide hybrid is cleaved; and an adapter nucleic acid is ligated to the cleaved target polynucleotide, thereby forming a tagged nucleic acid sequence. Also provided is a method of forming a tagged single stranded cDNA; a method of forming a plurality of tagged heterogeneous nucleic acid sequences; a library of recognition-oligonucleotides; and methods for amplifying a cDNA sequence immobilized on a solid support. These methods and products can be used alone or in combination for integrated single cell sequencing, and can be adapted for use in a microfluidic apparatus or device.Type: ApplicationFiled: December 21, 2018Publication date: August 15, 2019Inventors: Jason A.A. West, Brian Fowler, Tze-Howe Charn, Christian F. Johnson, Marc A. Unger
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Publication number: 20190185929Abstract: Described herein are cell-based analytic methods, including a method of incorporating nucleic acid sequences into reaction products from a cell population, wherein the nucleic acid sequences are incorporated into the reaction products of each cell individually or in small groups of cells individually. Also described herein is a matrix-type microfluidic device that permits at least two reagents to be delivered separately to each cell or group of cells, as well as primer combinations useful in the method and device.Type: ApplicationFiled: December 10, 2018Publication date: June 20, 2019Applicant: Fluidigm CorporationInventors: Carolyn G. Conant, Tze Howe Charn, Jason A. A. West, Xiaohui Wang
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Patent number: 10190163Abstract: Described herein are cell-based analytic methods, including a method of incorporating nucleic acid sequences into reaction products from a cell population, wherein the nucleic acid sequences are incorporated into the reaction products of each cell individually or in small groups of cells individually. Also described herein is a matrix-type microfluidic device that permits at least two reagents to be delivered separately to each cell or group of cells, as well as primer combinations useful in the method and device.Type: GrantFiled: February 26, 2016Date of Patent: January 29, 2019Assignee: FLUIDIGM CORPORATIONInventors: Carolyn G. Conant, Tze Howe Charn, Jason A. A. West, Xiaohui Wang
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METHODS, SYSTEMS, AND DEVICES FOR MULTIPLE SINGLE-CELL CAPTURING AND PROCESSING USING MICRO FLUIDICS
Publication number: 20180306683Abstract: Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing.Type: ApplicationFiled: March 19, 2018Publication date: October 25, 2018Applicant: Fluidigm CorporationInventors: Brian Fowler, Jake Kimball, Myo Thu Maung, Andrew May, Michael C. Norris, Dominique G. Toppani, Marc A. Unger, Jing Wang, Jason A.A. West -
Patent number: 9952126Abstract: Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing.Type: GrantFiled: February 28, 2013Date of Patent: April 24, 2018Assignee: Fluidigm CorporationInventors: Brian Fowler, Jake Kimball, Myo Thu Maung, Andrew May, Michael C Norris, Dominique Toppani, Marc A. Unger, Jing Wang, Jason A. A. West
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Patent number: 9828954Abstract: A fuel control system for an engine includes a closing module and a purge control module. The closing module commands closing of a purge valve in response an engine speed transitioning from greater than a predetermined speed to less than the predetermined speed while the purge valve is in an open state. The predetermined speed is less than a predetermined target speed of the engine and is greater than zero. The purge control module transitions the purge valve from the open state to a closed state in response to the command.Type: GrantFiled: August 31, 2015Date of Patent: November 28, 2017Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Steven Ward Majors, Scott Jeffrey, Jason West
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Patent number: 9815055Abstract: Provided are microfluidic devices and methods for fabricating and bonding such devices. Also provided are kits for analyzing analyte-containing samples and for lysing cells.Type: GrantFiled: August 19, 2016Date of Patent: November 14, 2017Assignee: FLUIDIGM CORPORATIONInventors: Jason A. A. West, Jesse Thompson
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Patent number: D1015838Type: GrantFiled: December 22, 2021Date of Patent: February 27, 2024Assignee: CleverMade, LLCInventors: Michael Carlson, Jason West