Abstract: Disclosed herein, in certain embodiments, are recombinant PNMA2 and endogenous Gag polypeptides, capsids comprising the recombinant PNMA2 or endogenous Gag polypeptides, and methods of making and using recombinant PNMA2 and endogenous Gag polypeptides.

Abstract: This invention relates generally to a system, device, and method for automated management of tension in tire chains and related traction improvement systems.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a leucine-rich repeat kinase 2 (LRRK2) gene, as well as methods of inhibiting expression of a LRRK2 gene and methods of treating subjects having a LRRK2-associated disease or disorder, e.g., Parkinson's disease, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) agents and compositions targeting the ATXN3 gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an ATXN3-associated disease or disorder, such as SCA3, using such dsRNA agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: A technique and device (12) may be utilized to determine a characteristic of a crystallographic texture of a sample (10) based on a detected ultrasonic waveform. The device may be configured to receive ultrasonic waveform data representative of a reflected ultrasonic waveform that propagated through a sample from an ultrasonic detector (14). The device may select a portion of the ultrasonic waveform data and apply a Fast Fourier Transform to the portion of the ultrasonic waveform data to transform the portion from a time domain to a frequency domain. The device then may identify a dominant frequency (98) of the portion in the frequency domain and determine a characteristic of a crystallographic texture for the portion based on the dominant frequency of the portion.

Abstract: A respirator container includes a sealable chamber that is adapted to receive and contain a respirator having a unique identifying tag. The respirator container also includes a reader for reading the unique identifying tag of a respirator in the sealable chamber, and a timer for measuring the time during which a respirator is outside of the sealable chamber.

Abstract: A system may include a data analysis device that is configured to receive from an ultrasonic waveform detector ultrasonic waveform data representative of an ultrasonic waveform that propagated through a sample and resonated within a defect within the sample. The data analysis device may be further configured to select a portion of the ultrasonic waveform data, apply a Fast Fourier Transform to the portion of the ultrasonic waveform data to transform the portion from a time domain to a frequency domain, identify a characteristic frequency of the portion in the frequency domain, and determine a characteristic of the defect based on the characteristic frequency of the portion. In some examples, the characteristic of the defect may be at least one of an approximate size or an approximate shape of the defect.

Abstract: A respirator container includes a sealable chamber that is adapted to receive and contain a respirator having a unique identifying tag. The respirator container also includes a reader for reading the unique identifying tag of a respirator in the sealable chamber, and a timer for measuring the time during which a respirator is outside of the sealable chamber.

Abstract: A tracking device and system are described where a location data collector device to receive location data of the tracking device and one or more communication devices that send the location data to a central facility and that receives a defined location package that includes location information where the tracking device is placed in either a suspension or active tracking mode.

Abstract: A system may include a data analysis device that is configured to receive from an ultrasonic waveform detector ultrasonic waveform data representative of an ultrasonic waveform that propagated through a sample and resonated within a defect within the sample. The data analysis device may be further configured to select a portion of the ultrasonic waveform data, apply a Fast Fourier Transform to the portion of the ultrasonic waveform data to transform the portion from a time domain to a frequency domain, identify a characteristic frequency of the portion in the frequency domain, and determine a characteristic of the defect based on the characteristic frequency of the portion. In some examples, the characteristic of the defect may be at least one of an approximate size or an approximate shape of the defect.

Abstract: A technique and device (12) may be utilized to determine a characteristic of a crystallographic texture of a sample (10) based on a detected ultrasonic waveform. The device may be configured to receive ultrasonic waveform data representative of a reflected ultrasonic waveform that propagated through a sample from an ultrasonic detector (14). The device may select a portion of the ultrasonic waveform data and apply a Fast Fourier Transform to the portion of the ultrasonic waveform data to transform the portion from a time domain to a frequency domain. The device then may identify a dominant frequency (98) of the portion in the frequency domain and determine a characteristic of a crystallographic texture for the portion based on the dominant frequency of the portion.

Abstract: A vehicle power outlet switch (10) can include a threshold detector (14) for comparing a predetermined threshold with a vehicle battery characteristic and a power switch (18) controlled by the output of the threshold detector. Note, the vehicle battery characteristic differs while the vehicle engine is turned on or turned off and the threshold detector provides an enabling signal to the power switch when the vehicle engine is detected as being on. The threshold detector can also provide a disabling signal to the power switch when the vehicle engine is off. The power outlet switch can further include a timer (16) coupled to an output of the threshold detector that continues to provide an enabling signal to the power switch for a predetermined time after the threshold detector detects that the vehicle engine is turned off. The timer can include or be a one shot timer.

Abstract: A vehicle power outlet switch (10) can include a threshold detector (14) for comparing a predetermined threshold with a vehicle battery characteristic and a power switch (18) controlled by the output of the threshold detector. Note, the vehicle battery characteristic differs while the vehicle engine is turned on or turned off and the threshold detector provides an enabling signal to the power switch when the vehicle engine is detected as being on. The threshold detector can also provide a disabling signal to the power switch when the vehicle engine is off. The power outlet switch can further include a timer (16) coupled to an output of the threshold detector that continues to provide an enabling signal to the power switch for a predetermined time after the threshold detector detects that the vehicle engine is turned off. The timer can include or be a one shot timer.