Patents by Inventor Jason A. Gough
Jason A. Gough has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240067968Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.Type: ApplicationFiled: August 18, 2023Publication date: February 29, 2024Applicant: Tune Therapeutics, Inc.Inventors: Brian COSGROVE, Kendra CONGDON, Jason DEAN, Veronica GOUGH, Joshua B. BLACK, Britta JONES
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Publication number: 20240067969Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.Type: ApplicationFiled: August 18, 2023Publication date: February 29, 2024Applicant: Tune Therapeutics, Inc.Inventors: Brian COSGROVE, Kendra CONGDON, Jason DEAN, Veronica GOUGH, Joshua B. BLACK, Britta JONES
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Patent number: 11474000Abstract: A system for dynamically mitigating resonance in a transport refrigeration unit (TRU) during a mission, having: a TRU controller configured for operating a TRU engine during the mission according to an operational baseline, and while operating the TRU engine, contemporaneously performing steps including: obtaining a first set of data that comprises real time measurements from one or more accelerometers installed in the TRU; converting the real measurements to a second set of data that comprises real time shock and vibration data; processing the second set of data in a control loop to determine an updated operational baseline that avoids resonance detected in the first set of data; and operating the TRU engine according to the updated operational baseline.Type: GrantFiled: March 19, 2019Date of Patent: October 18, 2022Assignee: CARRIER CORPORATIONInventors: Thomas Dewolf, Richard Clark, Robert A. Chopko, Christopher G. Repice, Michael Balistreri, Jason A. Gough
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Patent number: 11365932Abstract: A transport refrigeration unit system (26) for cooling a trailer compartment (24) is provided. The transport refrigeration unit system (26) includes an engine for controlling a cooling rate capacity, the engine operable at a nominal high speed and a nominal low speed. Also included is a controller (50) in operative communication with the engine to control an engine speed of the engine. Further included is a user interface (52) in operative communication with the controller (50), the user interface (52) providing a high capacity cooling mode to a user, wherein initiation of the high capacity cooling mode includes the engine operating at a speed greater than the nominal high speed to result in a high capacity cooling rate.Type: GrantFiled: July 11, 2017Date of Patent: June 21, 2022Assignee: CARRIER CORPORATIONInventors: Jason A. Gough, Travis William Corley
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Publication number: 20190285510Abstract: Disclosed is a system for dynamically mitigating resonance in a transport refrigeration unit (TRU) during a mission, having: a TRU controller configured for operating a TRU engine during the mission according to an operational baseline, and while operating the TRU engine, and contemporaneously performing steps including: obtaining a first set of data that comprises real time measurements from one or more accelerometers installed in the TRU; converting the real measurements to a second set of data that comprises real time shock and vibration data; processing the second set of data in a control loop to determine an updated operational baseline that avoids resonance detected in the first set of data; and operating the TRU engine according to the updated operational baseline.Type: ApplicationFiled: March 19, 2019Publication date: September 19, 2019Inventors: Thomas Dewolf, Richard Clark, Robert A. Chopko, Christopher G. Repice, Michael Balistreri, Jason A. Gough
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Publication number: 20190285325Abstract: An illustrative example refrigeration system includes a cooling apparatus, a generator that provides electrical power to the cooling apparatus, and an engine that provides power to the generator. A processor is configured to determine an ambient temperature, determine a load of the generator, determine a temperature of the generator, and determine whether the temperature of the generator exceeds a threshold, which is dependent on the ambient temperature and the load of the generator.Type: ApplicationFiled: February 11, 2019Publication date: September 19, 2019Inventors: Jason A. GOUGH, Christopher G. REPICE, Michael BALISTRERI
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Publication number: 20190263218Abstract: A transport refrigeration unit system (26) for cooling a trailer compartment (24) is provided. The transport refrigeration unit system (26) includes an engine for controlling a cooling rate capacity, the engine operable at a nominal high speed and a nominal low speed. Also included is a controller (50) in operative communication with the engine to control an engine speed of the engine. Further included is a user interface (52) in operative communication with the controller (50), the user interface (52) providing a high capacity cooling mode to a user, wherein initiation of the high capacity cooling mode includes the engine operating at a speed greater than the nominal high speed to result in a high capacity cooling rate.Type: ApplicationFiled: July 11, 2017Publication date: August 29, 2019Inventors: Jason A. Gough, Travis William Corley
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Patent number: 10107222Abstract: A system for testing a particulate filter system includes a filter controller connected to the particulate filter system and a vehicular computer configured to determine at least one engine condition. The filter controller is configured to control a condition of a component of the particulate filter system and the vehicular computer is operatively connected to the filter controller to communicate therewith. The vehicular computer compares the condition of the component of the particulate filter system with the engine condition to determine whether the component of the particulate filter system is functioning properly.Type: GrantFiled: January 16, 2015Date of Patent: October 23, 2018Assignee: Carrier CorporationInventors: Jason A. Gough, Garrison S. Moseley, Michael Stockbridge, John T. Steele
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Patent number: 9864375Abstract: An area isolation system (AIS) is provided. The AIS may include a barrier adjacent to a work area, a barrier control panel (BCP) operatively connected to and disposed proximate the barrier, the BCP including a BCP controller in communication with a BCP short-range transceiver, the BCP controller configured to control the barrier, and a machine configured to autonomously operate within the work area. The machine may include a remote shutdown module (RSM) having an RSM controller in communication with an RSM short-range transceiver, and an RSM unique identifier preprogrammed into a memory associated with the RSM controller. The RSM short-range transceiver may be configured to send signals indicative of the RSM unique identifier to the BCP short-range transceiver when a machine radio zone associated with the RSM short-range transceiver intercepts with a BCP radio zone associated with the BCP short-range transceiver.Type: GrantFiled: November 21, 2016Date of Patent: January 9, 2018Assignee: Caterpillar Inc.Inventors: Euan Kirkhope, Darren Anderson, Jason Gough, Peter Broughton, Joshua Bynon
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Publication number: 20170167423Abstract: A system for testing a particulate filter system includes a filter controller connected to the particulate filter system and a vehicular computer configured to determine at least one engine condition. The filter controller is configured to control a condition of a component of the particulate filter system and the vehicular computer is operatively connected to the filter controller to communicate therewith. The vehicular computer compares the condition of the component of the particulate filter system with the engine condition to determine whether the component of the particulate filter system is functioning properly.Type: ApplicationFiled: January 16, 2015Publication date: June 15, 2017Inventors: Jason A. GOUGH, Garrison S. MOSELEY, Michael STOCKBRIDGE, John T. STEELE
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Publication number: 20130175016Abstract: A heat exchanger (28 includes a first manifold (34), a second manifold (36) and a plurality of parallel heat transfer tubes (38). The first manifold (34) includes one or more manifold sections (58, 60, 63). A first one of the manifold sections (58) is connected to an inlet (64). The heat transfer tubes (38) extend between and fluidly connect the first and the second manifolds (34, 36). At least some of the heat transfer tubes (38) are disposed with the first manifold section (58).Type: ApplicationFiled: December 23, 2010Publication date: July 11, 2013Applicant: CARRIER CORPORATIONInventors: John T. Steele, Eric Johnson, Lester G. Harrington, Christopher G. Repice, Jason A. Gough, Scott D. Fulmer
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Patent number: 8291721Abstract: A transport refrigeration system having a structural framework supporting a refrigeration unit including a condenser heat exchanger supported in an upper region of the framework and an engine and an electric generator powered by the engine supported by the framework in an engine compartment in a lower region of the framework, includes a pair of vertically disposed condenser fan/motor assemblies disposed aft of the condenser heat exchanger in side-by-side relationship and above the engine compartment; and a flow partition extending vertically between the pair of condenser fan/motor assemblies.Type: GrantFiled: February 24, 2009Date of Patent: October 23, 2012Assignee: Carrier CorporationInventors: Richie C. Stauter, Peter R. Bushnell, Stephen Stopyra, Donald B. Hotaling, Jason A. Gough
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Patent number: 8125110Abstract: An engine driven generator (17) is provided with first and second stage fans (41,42) at one end thereof. The two-stage fan system draws in ambient air and forces it through the generator windings (38) and rotor-stator air gap (37,39) for the purpose of improving generator cooling. Stationary guide vanes (49) are disposed between the two fans (41,42) for the purpose of de-swirling the flow therebetween. The fans are of the centrifugal type and are preferably backward curved.Type: GrantFiled: June 12, 2007Date of Patent: February 28, 2012Assignee: Carrier CorporationInventors: Peter R. Bushnell, Jason A. Gough, Curt B. Winter, Stephen Stopyra
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Publication number: 20100176603Abstract: An engine driven generator (17) is provided with first and second stage fans (41,42) at one end thereof. The two-stage fan system draws in ambient air and forces it through the generator windings (38) and rotor-stator air gap (37,39) for the purpose of improving generator cooling. Stationary guide vanes (49) are disposed between the two fans (41,42) for the purpose of de-swirling the flow therebetween. The fans are of the centrifugal type and are preferably backward curved.Type: ApplicationFiled: June 12, 2007Publication date: July 15, 2010Inventors: Peter R. Bushnell, Jason A. Gough, Curt B. Winter, Stephen Stopyra
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Publication number: 20090211286Abstract: A transport refrigeration system having a structural framework supporting a refrigeration unit including a condenser heat exchanger supported in an upper region of the framework and an engine and an electric generator powered by the engine supported by the framework in an engine compartment in a lower region of the framework, includes a pair of vertically disposed condenser fan/motor assemblies disposed aft of the condenser heat exchanger in side-by-side relationship and above the engine compartment; and a flow partition extending vertically between the pair of condenser fan/motor assemblies.Type: ApplicationFiled: February 24, 2009Publication date: August 27, 2009Applicant: CARRIER CORPORATIONInventors: Richie C. Stauter, Peter R. Bushnell, Stephen Stopyra, Danald B. Hotaling, Jason A. Gough
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Publication number: 20090211288Abstract: A transport refrigeration system includes a single frame for containing both a refrigeration condenser coil and an engine coolant radiator arranged in serial airflow relationship within a framework. Either one or the other may be removed and replaced without replacing the other.Type: ApplicationFiled: February 24, 2009Publication date: August 27, 2009Applicant: CARRIER CORPORATIONInventors: Robert S. Simeone, Jason A. Gough, Eric J. Johnson, John T. Steele, Donald B. Hotaling