Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A treatment fluid for performing one or more pre-cementing operations in a wellbore can include a base fluid, a viscosifier, and a crushed glass material. The viscosifier can be dispersed in the base fluid. The crushed glass material can be dispersed in the base fluid for performing one or more cementing operations with respect to the wellbore.

Abstract: A change monitoring system and method includes or involves, in an embodiment, a data storage device having a plurality of instructions. The instructions are executable to direct one or more processors to access reference gaming deployment data based on an electronic communication with a processor that is associated with a gaming environment. The reference gaming deployment data is related to one or more gaming units that have been operated in the gaming environment during a first period of time. The one or more gaining units correspond to a reference gaming deployment in the gaming environment during the first period. Also, the instructions are executable to direct the one or more processors to access changed gaming deployment data based on the electronic communication with the processor. The changed gaming deployment data is related to a change to the reference gaming deployment that has resulted in a changed gaming deployment that was implemented during a second period of time after the first period.

Abstract: The present invention relates to compounds which are useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract: A bulk dry cement may comprise a cement; a solid particle; and a liquid resin accelerator, wherein the liquid resin accelerator is disposed on a surface of the solid particle.

Abstract: The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract: Compositions for foamed treatment fluids are disclosed. The foamed treatment fluid may comprise a cement, a viscosifying agent, a thixotropic additive, a foaming surfactant, a gas, and water. The foaming surfactant may comprise a polyethylene glycol alkyl ether (C5-C10), sulfate ammonium salt.

Abstract: The exemplary embodiments are related to a pipeline manager configured to manage a software development pipeline. The pipeline manager receives, via a user interface (UI), a representation of a pipeline comprising a plurality of blocks, wherein each block comprises a defined input and a defined output, executes each block of the pipeline, validates output of each block of the pipeline based on the execution of the block and stores the output of each block and updating data that defines the pipeline based on the output of each block.

Abstract: Methods of inhibiting the spread of African swine fever virus and/or classical swine fever virus in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids. The chemical mitigants are effective when introduced to the feed or feed ingredients at inclusion rates much lower than previous methods for inhibiting other microbes. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: A surgical stapler includes a first elongate member, a second elongate member, and a clamp member operable to releasably clamp the first elongate member against the second elongate member. A distal portion of the first elongate member supports an anvil surface having a plurality of staple forming pockets. A distal portion of the second elongate member is configured to receive a staple cartridge. A firing assembly of the surgical stapler is translatable from a first longitudinal position to a second longitudinal position to fire the staple cartridge when the first elongate member is clamped against the second elongate member. A retaining assembly of the surgical stapler includes a first retaining member configured to releasably couple a proximal end of the first elongate member with a proximal end of the second elongate member, and a second retaining member configured to releasably retain the firing assembly in the first longitudinal position.

Abstract: The present disclosure relates to a modular system for deep brain stimulation (DBS) and electrocorticography (ECoG). The system may have an implantable neuromodulator for generating electrical stimulation signals adapted to be applied to a desired region of a brain via an attached electrode array. An aggregator module may be used for collecting and aggregating electrical signals and transmitting the electrical signals to the neuromodulator. A control module may be used which is in communication with the aggregator module for controlling generation of the electrical signals and transmitting the electrical signals to the aggregator.

Abstract: A surgical stapler includes a first elongate member having a distal portion that supports a plurality of staple-forming pockets, a second elongate member having a distal portion that supports a staple cartridge, and a clamp member movable from an open position to a closed position to releasably clamp the first and second elongate members together. A clamp lockout feature is supported by the first elongate member and is moveable between a lockout position in which the clamp lockout feature prevents closure of the clamp member, and a release position in which the clamp lockout feature permits closure of the clamp member. An actuating feature is supported by the second elongate member and is configured to actuate the clamp lockout feature from the lockout position to the release position in response to approximation of the distal portions of the first and second elongate members.

Abstract: A system for manufacturing a thermoplastic object may include a robotic arm configured to dispense thermoplastic material, a support apparatus, a computing device and an imaging system. The imaging system may scan thermoplastic material dispensed by the first robotic arm and create a three-dimensional scan model. The model may be compared to a computer model profile to determine if the dispensed material requires adjustment. If the dispensed material requires adjustment, the computing device may adjust the robotic arm or the support apparatus.

Abstract: A method and system for dynamically transferring graphical image processing operations from a graphical processing unit (GPU) to a digital signal processor (DSP). The method includes estimating the number of operations needed for the processing a set of image data; determining the operational limits of a GPU and compare with estimated number of operations and if the operational limits are exceeded; transfer the processing operations to the DSP from the GPU. The transfer can include transferring a portion of executable code for performing the processing operations, and generating a replacement code for the GPU. The DSP can then process a portion of the image data before sending it to the GPU for further processing.

Abstract: The disclosure includes a system and method are described for receiving, using one or more processors, a request to generate a report based on an identified data set; determining, using one or more processors, a first statistical approach to apply to the identified data set automatically; applying, using one or more processors, the first statistical approach to the identified data; generating, using one or more processors, a report including one or more charts based on at least one statistical approach; and presenting, using the one or more processors, the report.

Abstract: A system for manufacturing a thermoplastic object may include a robotic arm configured to dispense thermoplastic material, a support apparatus, a computing device and an imaging system. The imaging system may scan thermoplastic material dispensed by the first robotic arm and create a three-dimensional scan model. The model may be compared to a computer model profile to determine if the dispensed material requires adjustment. If the dispensed material requires adjustment, the computing device may adjust the robotic arm or the support apparatus.

Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.

Abstract: A galactic extrusion manufacturing (GEM) system for performing an extrusion process includes an extruder assembly for extruding building material during the extrusion process, and a connection system including a robotic arm-tether-crimper for attachment of the GEM system to space bound vehicles and/or structures in space or on orbit. The extrusion assembly includes an extruder head outfitted with multiple different heads for shaping the building material during the extrusion process, at least one power cartridge, and at least one building material cartridge containing the building material, wherein the power cartridge and the building material cartridge are removable and replaceable. Also provided are a building material cartridge for use with a GEM system or a dispensing control unit (DCU) to perform an extrusion process, and a smart extrusion system including a building material cartridge and a DCU.