Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.

Abstract: An HVACR fan and heater assembly accounts for the cyclonic flow produced by centrifugal blowers by placing a heater vertically and biased towards a side of a fan cabinet in order to increase and balance airflow through the heater, eliminating hot spots and fire risk and improving heater efficiency. A blockoff in the fan cabinet forces airflow within the cabinet to move through the heater. The positioning of the heater may vary depending on the direction of rotation of the centrifugal blower. The fan and heater assembly may further include baffles to direct the airflow from the centrifugal blower.

Abstract: Silica-based organogels, including aerogels, incorporating hexahydrotriazine and/or hemiaminal species are described. These organo-silica gel materials can have applications as insulating materials. In a particular example, an aerogel includes silica groups and a hexahydrotriazine moiety with at least one nitrogen atom that is covalently linked to a silica group. Methods of making such silica-based organogels are also described.

Abstract: A furniture member may include a stationary frame assembly and a seat bottom assembly. The stationary frame assembly may include a stationary base frame and a stationary seatback frame that is fixed relative to the base frame. The seat bottom assembly may be supported by the base frame and movable relative to the base frame and the seatback frame between a first position and a second position. The seatback frame is disposed vertically higher than the base frame and the seat bottom assembly.

Abstract: A microfluidic delivery device and method of dispensing a fluid composition therefrom is provided. The microfluidic delivery device includes a housing electrically connectable with a power source; a cartridge releasably connectable with the housing; and a fan connected with the housing. The cartridge has a reservoir for containing a fluid composition and microfluidic die in fluid communication with the reservoir. The die is configured such that substantially all of the fluid composition exits the microfluidic die in a horizontal direction or downward direction relative to horizontal. The fan is configured to generate air flow that converges with and redirects the fluid composition dispensed from the microfluidic die in an upward direction relative to horizontal.

Abstract: The present invention provides cell-targeting molecules comprising binding regions for cell-type specific targeting and Shiga toxin A Subunit effector regions for Shiga toxin effector functions, wherein the Shiga toxin effector regions are at and/or proximal to an amino-terminus of a polypeptide component of the cell targeted molecule, and optionally comprising a disrupted, furin-cleavage motif between the Shiga toxin effector region and the binding region. The cell-targeting molecules of the invention exhibit a more optimized cytotoxicity and/or improved, in vivo tolerability as compared to related molecules comprising less amino-terminus proximal, Shiga toxin effector regions and/or furin-cleavage sensitive, wild-type, Shiga toxin effector regions. The cell targeting molecules of the invention have uses, such as, e.g.

Abstract: A dental cleaning appliance includes a handle and a fluid delivery system for delivering a burst of working fluid to the teeth of a user. Part of the fluid delivery system is moveable relative to the handle as the appliance is moved along the teeth of the user. A sensor provides an output which varies with movement of that part of the fluid delivery system relative to the handle. A control circuit actuates the delivery of working fluid to the teeth of the user depending on the output from the sensor.

Abstract: Intervertebral spacer assemblies, systems, and methods thereof. A method of insertion include inserting an intervertebral spacer and plate together using an insertion tool and, upon removal of the insertion tool, the intervertebral spacer and plate are no longer considered connected/coupled and act as separate components.

Abstract: A system, apparatus, and methods are provided for automatically managing a collection of service instances. A selected or random instance of the service isredline-tested to determine a maximum level of sustained and stable performance (e.g., a maximum or approximate maximum load or throughput of the service instance). This redline value may represent a highest service request rate (e.g., in queries per second or qps) that should be delivered to some or all instances of the service. An expected range of demand for the service is then estimated for a future time period, possibly from analysis and/or observations of past demand, and a maximum and minimum number of instances for handling that range of demand, at an acceptable level of performance, can be determined. During the time period, additional instances may be created and superfluous instances may be removed automatically, based on actual demand.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an alkyne (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

Abstract: An Infrared Detector Dewar system includes a housing and an infrared detector. The system also includes one or more strut members coupled on a first end to the housing. The system further includes cold shield coupled to the infrared detector and to a second end of the one or more strut members. The cold shield includes a reinforcement ring aligned with the one or more strut members. The cold shield is formed by forming a support member having disc encased by a support ring. The support member is positioned within a mandrel such that the reinforcement ring is disposed to align with a strut position. The cold shield is then formed by electroplating copper over the mandrel and at least a portion of the support member, and then by removing/dissolving all aforementioned mandrels.

Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.

Abstract: Comb-block copolymers of isobutylene copolymer backbone with functional comb arms, methods for making a comb-block copolymer comprising polymerizing one or more monomer components comprising units derived from at least one of acrylates, vinyl terminated C6 to C20 aromatics, acrylamides, and acrylonitrile using a halogenated copolymer initiator having a benzylic-halide moiety via atom transfer radical polymerization (ATRP) in the presence of a transition metal complex catalyst at a temperature ranging from 30° C. to 150° C., the use of these comb-block copolymers as a tire tread additive, as a nanofiller dispersant in elastomeric nanocomposite compositions comprising halobutyl rubber, as a surfactant, as a sealant, and as an additive in a latex formulation is disclosed.

Abstract: Application of lecithin-based oil compositions to additive particles to control dusting. Without limitation, a method of reducing an amount of dust produced during transfer of additive particles in well operations may comprise providing treated additive particles comprising additive particles and a lecithin based oil composition disposed on a surface of at least portion of the particles. The lecithin -based oil composition may comprise a lecithin and an organic solvent. The method may further comprise mixing components comprising the treated additive particles and a base fluid to provide a treatment fluid. The method may further comprise introducing the treatment fluid into a subterranean formation.

Abstract: A drill bit includes a cone section, a blade flank section, a blade shoulder section, and a plurality of blades connected to the bit body and extending away from the bit body. At least one cutting element is positioned on at least one of the plurality of blades. In addition, a plurality of thermally stable polycrystalline cutters is positioned on at least one of the plurality of blades in at least one of the cone section, the blade flank section, and the blade shoulder section of the at least one of the plurality of blades. The thermally stable polycrystalline cutters include a cutting edge that defines a line, wherein the line is substantially parallel to a tangent line of a radius line that extends from a center of the drill bit to the cutting edge.

Abstract: A guide pin for aligning fiber optic ferrules includes an elongated cylindrical element with a proximal end, a distal end, a longitudinal axis therethrough, and a diameter. The distal end has a configuration to be insertable into a first ferrule to align the fiber optic ferrules. The proximal end is configured to be inserted into and retained in a guide pin opening in a second ferrule, the guide pin opening in the second ferrule having a diameter, the proximal end of the elongated cylindrical element having a first portion having a profile that is related to an arc with radius equal to or smaller than the diameter of the guide pin opening and a second portion having a profile defined by a line associated with the arc, the second portion being proximal relative to the first portion.

Abstract: The present invention is an assembly layer for a flexible device. Within a temperature range of between about ?30° C. to about 90° C., the assembly layer has a shear storage modulus at a frequency of 1 Hz that does not exceed about 2 MPa, a shear creep compliance (J) of at least about 6×10?6/Pa measured at 5 seconds with an applied shear stress between about 50 kPa and about 500 kPa, and a strain recovery of at least about 50% at at least one point of applied shear stress within the range of about 5 kPa to about 500 kPa within about 1 minute after removing the applied shear stress.

Abstract: A shin guard protection assembly may include a shin guard plate for protecting a shin area of a wearer, an upper leg pad attached to the shin guard plate. The upper leg pad may be configured for being interposable between the shin guard plate and a shin of the wearer. The assembly may include a lower leg pad removably attachable to the upper leg pad, the lower leg pad configured to be repositionable along a lower leg of the wearer. The assembly may include an adjustable securing mechanism configured to secure the shin guard plate and upper leg pad about a leg of the wearer.

Abstract: Systems and methods are disclosed for sampling a set of data using inverted indexes in response to a user interaction with a user interface. Based on the user interaction with a displayed grouping of a summarization of a set of data, the system uses filter criteria corresponding to the grouping to review one or more inverted indexes and identify a sample of events for analysis. The system then accesses the sample of events and provides the results for display to a user.

Abstract: A delivery device includes an inner shaft, an outer sheath, a nosecone, and a tether component. The outer sheath is slidably disposed over the inner shaft. The nosecone is removably coupled to the inner shaft. The nosecone includes a delivery configuration for delivery to a treatment site, a radially compressed configuration in which a portion of the nosecone is configured to traverse through a heart wall, and a radially expanded configuration in which an outer surface of the nosecone contacts an outer surface of the heart wall. The tether component includes a first end coupled to the nosecone. The nosecone is configured to plug a piercing in the heart wall when in the radially expanded configuration.