Abstract: The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D??(Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A is Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.

Abstract: A method for preventing or reducing engine knock or pre-ignition in a high compression spark ignition engine lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition that contains (i) a lubricating oil base stock comprising at least one branched ester having at least about 15% of the total carbons in the form of methyl groups, and (ii) at least one ashless antiwear additive selected from a phosphorus-containing ashless antiwear additive, a sulfur-containing ashless antiwear additive, and a phosphorus/sulfur-containing ashless antiwear additive.

Abstract: This application relates to securing and positioning internal components within a housing of a portable computing device. In one embodiment, a number of insert molded retaining members are utilized to inhibit outward deformation of a sidewall of the housing during a drop event. In another embodiment, a cowling is utilized to retain a number of board-to-board connectors within communication slots on a printed circuit board (PCB). In another embodiment, a C-shaped washer having diametrically opposed protrusions is utilized to adjust an alignment of an internal component.

Abstract: Devices and methods for treating one or more damaged, diseased, or traumatized portions of the spine, including intervertebral discs, to reduce or eliminate associated back pain. In one or more embodiments, the present invention relates to an expandable interbody spacer. The expandable interbody spacer may comprise a first jointed arm comprising a plurality of links pivotally coupled end to end. The expandable interbody spacer further may comprise a second jointed arm comprising a plurality of links pivotally coupled end to end. The first jointed arm and the second jointed arm may be interconnected at a proximal end of the expandable interbody spacer. The first jointed arm and the second jointed arm may be interconnected at a distal end of the expandable interbody spacer.

Abstract: A method includes determining, by a first client and a second client module, that a first data object and a second data objects are related. The method further includes dispersed storage error encoding the first data object to produce a first plurality of sets of encoded data slices and the second data object to produce a second plurality of sets of encoded data slices. The method further includes sending, by the first client module, first requests regarding the first plurality of sets of encoded data slices to a set of storage units. The method further includes sending, by the second client module, second requests regarding the second plurality of sets of encoded data slices to the set of storage units. The method further includes processing, by a binding module, remaining phases of the first and second write requests as a single write operation for the first and second data objects.

Abstract: In an aspect, in general, a spooling apparatus includes a filament feeding mechanism for deploying and retracting filament from the spooling apparatus to an aerial vehicle, an exit geometry sensor for sensing an exit geometry of the filament from the spooling apparatus, and a controller for controlling the feeding mechanism to feed and retract the filament based on the exit geometry.

Abstract: Systems and methods that use far-field diverting agents and proppant pulsing to enhance fracture geometries in far field areas of a subterranean formation are provided. In one embodiment, the methods comprise: introducing into a well bore penetrating a portion of a subterranean formation alternating stages of a proppant-carrying fracturing fluid comprising a plurality of proppant particulates, and a clean fracturing fluid comprising a lesser concentration of proppant particulates than the proppant-carrying fracturing fluid, wherein the alternating stages of the proppant-carrying fracturing fluid and the clean fracturing fluid are introduced into the well bore at or above a pressure sufficient to create or enhance one or more fractures in the subterranean formation; and introducing a diverting agent into the well bore during one or more of the alternating stages of proppant-carrying fracturing fluid and clean fracturing fluid.

Abstract: A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling.

Abstract: A data center security system and method are provided that leverage server systems on a chip (SOCs) and/or server fabrics. In more detail, server interconnect fabrics may be leveraged and extended to dramatically improve security within a data center.

Abstract: Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

Abstract: Methods and systems for interface data utilization are described. In one embodiment, a provider server may offer resources and an application server may offer functionality not provided by the resources of the provider server. A user request may be received through the source user interface. A determination may be made whether the user request contains a request to access a functionality that is not offered by the provider but is offered by an application that is communicatively coupled to the provider via a network. In response, an electronic communication may be established between the provider and the application via a network. A policy of the provider may be accessed from a first database, and interface definition data may be accessed from a second database different from the first database. Target interface data may be rendered based on the policy of the provider and the interface definition data.

Abstract: A plurality of virtual computing resources is detected to have been provisioned. Credentials are distributed to the plurality of virtual computing resources. A credentials map that maps the credentials to the plurality of virtual computing resources is updated. The credentials for the plurality of virtual computing resources are activated to enable the plurality of virtual computing resources to use the credentials to authenticate to a second computer system that manages a resource service, with the credentials being inaccessible to resources of the resource service. A virtual computing resource of the plurality of virtual computing resources is detected to been deprovisioned, and the credentials for the virtual computing resource are deactivated.

Abstract: In an aspect, an update unit can evaluate condition(s) in an update request and update one or more memory locations based on the condition evaluation. The update unit can operate atomically to determine whether to effect the update and to make the update. Updates can include one or more of incrementing and swapping values. An update request may specify one of a pre-determined set of update types. Some update types may be conditional and others unconditional. The update unit can be coupled to receive update requests from a plurality of computation units. The computation units may not have privileges to directly generate write requests to be effected on at least some of the locations in memory. The computation units can be fixed function circuitry operating on inputs received from programmable computation elements. The update unit may include a buffer to hold received update requests.

Abstract: Methods, systems, and techniques for annotating large amounts of data are provided. Example embodiments provide a Scalable Annotation Architecture (a “SAS”), which builds predictive models for an annotation from the ground up, without knowledge of the data. The SAS operates by performing in an iterative fashion a process that seeds training data and hypothesizes a predictive model based upon that data, then sends samples of the data to a crowdsourcing environment to provide selective verification. This process is repeated iteratively until a desired precision is reached and then the model is employed independently in a production system. In one embodiment, the SAS is used to annotate data provided by an open data platform.

Abstract: A portable electric height adjustable platform assembly, and method of use, the assembly residing on a fixed height desktop to move a computer monitor, keyboard, and mouse between a user's sitting and standing position. The platform assembly comprises: a horizontally positioned platform unit configured for supporting a computer keyboard and mouse; a height adjustable lifting column unit comprising three telescopic sections, affixed vertically to the platform, with the outer section positioned above the platform unit to affix the monitor to, and the middle and inner section extensible below the platform to raise-lower the assembly; a base unit affixed to the bottom end of the lifting column unit, and configured to stabilize the assembly in a vertical position; an electric actuator housed within and able to activate the lifting column unit to vertically extend and collapse the telescopic sections, thus simultaneously raising and lowering the computer monitor, keyboard, and mouse.

Abstract: A system allows dwelling access to third parties. An intelligent door lock system at the dwelling includes a device configured to be coupled to a drive shaft of a lock device, with the device sensing movement of the drive shaft to assist in locking and unlocking a lock of a lock device. The intelligent door lock system is configured to be in communication with a server. An occupant/or owner, or end-dwelling user of the dwelling communicates with the server to grant a third party secured access to a dwelling, which can by programmatic.

Abstract: A fan shaft includes a first end, a second end, and an axis, the fan shaft and configured to be coupled to a gear assembly of a gas turbine engine at the first end and to a fan more proximal to the second end than the first end such that in response to being coupled, the fan shaft can transfer torque from the gear assembly to the fan. At least one axial portion of the fan shaft satisfies the relationship 0.55 ? T * C J * ? ? 0.95 , where T represents peak torque during fan blade off, C represents a distance from a centerline of the gas turbine engine to an outer fiber of the fan shaft, J represents a polar moment of inertia of the fan shaft, and ? represents yield stress in shear of the fan shaft.

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, whilst discarding less optimal data.

Abstract: A method to receive media service application program into a media playback device includes scanning a quick response (QR) code containing a universal resource locator of a first server and an identifier of the media player device. The first server is accessed and a universal resource locator is provided to the media playback device to download an appropriate media service application for the media playback device from a second server. The media playback device installs the media service application and configures it for operation by a user. Multiple media services may be encoded in a QR code for a single media playback device. Multiple media playback devices may be associated with a single media service on a QR code.

Abstract: A dielectric fluid and coolant for electrical apparatuses such as transformers. In one embodiment, the fluid contains more than 25% biobased base oil, such as a biobased hydrocarbon oil, which has a molecular weight greater than 300 g/mol and less than 595 g/mol. The biobased base oil may optionally be blended with other oils, such as mineral oils and vegetable oils.