Abstract: This invention concerns various methods of using labeled HSP90 inhibitors to improve treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor.

Abstract: A combined transformer/inductor device includes a core having a central core leg and an outer core leg spaced apart from the central core leg, an inner bobbin disposed around the central core leg, an outer bobbin disposed around the inner bobbin and the central core leg and having an upper portion having a first oblong portion disposed around the outer core leg, a lower portion having a second oblong portion disposed around the outer core leg, and a central portion disposed around the inner bobbin and the central core leg, a first winding wound around the inner bobbin, and a second winding wound around the outer bobbin, the second winding having a first portion wound around the first oblong portion, a second portion wound around the central portion, and a third portion wound around the second oblong portion.

Abstract: Various examples are directed to systems and methods for operating a surgical instrument comprising a firing member translatable proximally and distally along a longitudinal axis between a stroke begin position to a stroke end position distal of the stroke begin position; a knife coupled to the firing member; and a motor coupled to the firing member to translate the firing member between the stroke begin position and the stroke end position. A control circuit may receive a firing signal and begin a firing member stroke by providing an initial motor setting to the motor. The control circuit may maintain the initial motor setting for an open-loop portion of the firing member stroke. The control circuit may receive firing member motion data describing a motion of the firing member during the open-loop portion of the firing member stroke and may select a firing control program based at least in part on the motion of the firing member during the open-loop portion of the firing member stroke.

Abstract: A method for displaying archived exercise classes comprising displaying information about archived exercise classes that can be accessed by a first user via a computer network on a display screen at a first location, wherein the first user can select among a plurality of archived classes, outputting digital video and audio content comprising the selected archived class, detecting a performance parameter for the first user at a particular point in the selected class, displaying the performance parameter on the display screen, and displaying performance parameters from a second user at a second location on the display screen such that at least one of the performance parameters from the first user and at least one of the performance parameters from the second user at the same point in the class are presented for comparison.

Abstract: The invention generally relates to sonar devices that integrate forward-looking sensors with down-looking echosounders, side scanning sonar, or both. The invention provides a sonar system that includes a forward-looking sonar device that operates in an integrated fashion with one or more other sonar devices so that a boater can have a reliable navigation tool while also using sonar for finding fish and other features on the seafloor. The forward-looking sonar can include a transducer array that takes a three-dimensional acoustic reading of the objects and seafloor ahead. The electronics that process the acoustic data can also process data from down-looking sonar, side-scanning sonar, or both and can integrate the information to present an expansive display in the boat, revealing the contents and the floor of the sea in front of, around, and under the boat.

Abstract: A music production system comprises: a computer interface comprising at least one input for receiving an external request for a piece of music and at least one output for transmitting a response to the external request which comprises or indicates a piece of music incorporating first music data; a first music production component configured to process second music data according to at least a first input setting so as to generate the first music data; a second music production component configured to receive via the computer interface an internal request, and provide the second music data based on at least a second input setting denoted by the internal request; and a controller configured to determine in response to the external request the first and second input settings, and instigate the internal request via the computer interface.

Abstract: A security document (200) includes a secure substrate (205). The secure substrate includes a viewing side (209) and a backing side (211), and a micro-optic system (305, 321) providing an optically variable effect (OVE) (513) on the viewing side. The security document further includes a protective layer (225), and a mask layer (215) disposed between the protective layer and the backing side of the secure substrate.

Abstract: Data processing systems and methods according to various embodiments are adapted for automatically detecting and documenting privacy-related aspects of computer software. Particular embodiments are adapted for: (1) automatically scanning source code to determine whether the source code include instructions for collecting personal data; and (2) facilitating the documentation of the portions of the code that collect the personal data. For example, the system may automatically prompt a user for comments regarding the code. The comments may be used, for example, to populate: (A) a privacy impact assessment; (B) system documentation; and/or (C) a privacy-related data map. The system may comprise, for example, a privacy comment plugin for use in conjunction with a code repository.

Abstract: A system configured for identifying unpermitted data in source code receives a search query comprising particular keywords related to the unpermitted data. The system labels the source code with vulnerability factors and categories of those vulnerability factors, where the vulnerability factors indicate a security vulnerability and the categories provide information about the security vulnerability of the source code. The system performs a static analysis on the source code to identify instances of the particular keyword in a data flow and control flow of the source code. The system performs a vulnerability analysis on the source code to determine a vulnerability level of the source code, in which factor weights and category weights for each code portion of the source code are determined. The system calculates a weighted sum of the factor weights and category weights for each code portion, thereby detecting instances of unpermitted data in source code.

Abstract: A portable insulin pump can integrate and display data from a continuous glucose monitor (CGM) to allow a user to more readily determine whether any interaction with the pump is necessary. Data from the CGM can automatically be transmitted to the pump and can be displayed for user analysis or automatically analyzed to present recommendations to the user based on combined data from the CGM and the pump.

Abstract: A vacuum cleaner attachment generally includes a cleaning element that floats relative to a suction conduit of the vacuum cleaner attachment. The cleaning element is supported on a support structure that is movably coupled to a housing and is biased towards a floor, for example, as a result of the weight of the cleaning element support structure. The cleaning element may be permanently attached to the support structure or may be a removable or disposable pad or sheet attached to the support structure. The floating cleaning element may be supported between the suction conduit and one or more wheels of the vacuum cleaner attachment. The vacuum cleaner attachment may be removably attached to a vacuum cleaner, for example, to be used interchangeably with other surface cleaning heads.

Abstract: An embodiment of a torch igniter for a combustor of a gas turbine engine includes a combustion chamber oriented about an axis, a cap defining an axially upstream end of the combustion chamber, a tip defining the axially downstream end of the combustion chamber, an igniter wall extending from the cap to the tip and defining a radial extent of the combustion chamber, a structural wall coaxial with and surrounding the igniter wall, an outlet passage defined by the igniter wall within the tip, a glow plug housing configured to receive a glow plug and allow an innermost end of the glow plug to extend into the combustion chamber, and a cooling system. The cooling system includes an air inlet formed within an exterior of the structural wall, a cooling channel forming a flow path through the structural wall at the glow plug housing, and an air passage.

Abstract: A slide gate assembly includes a mounting plate with a through opening and an upper surface, and a top plate with a through opening and lower surface, wherein the through opening of the top plate aligns with the through opening of the mounting plate. A slide plate is mounted between the lower surface of the top plate and the upper surface of the mounting plate, wherein the slide plate is slidable between a closed position and an open position, wherein, in the closed position the slide plate blocks material passage from the opening of the top plate to the opening of the bottom plate, wherein, in the open position, the slide plate permits material passage from the opening of the top plate to the opening of the bottom plate.

Abstract: Provided herein are heteroaryl inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: A combination lock for electronic devices may include a main body, a digit lock core, a key lock core, a control unit, a driving block, a switching unit, and two engaging units. The combination lock can be locked/unlocked through the digit lock core and the key lock core, and also when the combination lock is locked on the electronic device, the main body can be axially rotated to enable a digit wheel of the digit lock core to be faced to the designated direction.

Abstract: The present invention provides systems and methods for improved communication management. The present invention provides a platform for providing intuitive, semi-automated, large-scale, two-way text messaging communication between a client or customer (e.g., business or company) and participants/recipients tied to, or otherwise associated or registered with a service provided by the client or customer. The platform provides a consolidated web-based interface with which the client/customer may interact to manage the handling of participant data and to further manage the transmission of targeted outgoing text messages to one or more participants.

Abstract: A gas elimination apparatus and a method for use in an intravenous delivery system are provided. The apparatus includes a fluid inlet coupling a fluid flow into a liquid chamber, a fluid outlet protruding into the liquid chamber, and a flow diversion member proximal to the fluid outlet. The flow diversion member configured to block a direct flow between the fluid inlet and the fluid outlet. The apparatus includes a membrane separating a portion of the liquid chamber from an outer chamber and a gas venting valve fluidically coupling the outer chamber with the atmosphere. The flow diversion member may be mechanically supported by at least one strut or elongate member extending along a flow direction into the liquid chamber.

Abstract: The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and/or pulmonary hypertension.

Abstract: Disclosed herein are system, method, and computer program product embodiments for assessing performance of a player of a game. An embodiment operates by monitoring for an input from the player of the game, receiving the input from the player of the game, and determining a characteristic of the game resulting from the input from the player. Based on the input from the player, a performance of the player is assessed. The performance of the player relating to one or more metrics of the game is monitored, and is assessed by comparing the input from the player during the period of time to an optimal input during the period of time in the game.