Patents by Inventor Jason Andrew MacLeod
Jason Andrew MacLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9752182Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: GrantFiled: August 28, 2014Date of Patent: September 5, 2017Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 9441259Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: November 21, 2014Date of Patent: September 13, 2016Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20150275261Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: November 21, 2014Publication date: October 1, 2015Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8986526Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 12, 2012Date of Patent: March 24, 2015Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20150064707Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: August 28, 2014Publication date: March 5, 2015Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 8883487Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.Type: GrantFiled: December 21, 2005Date of Patent: November 11, 2014Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 8703445Abstract: The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal, an egress with a second reversible seal, a sealable sample entry orifice, and a first wall forming a portion of the chamber. The first wall includes a thermally conductive material and includes an interior surface and an exterior surface. The exterior surface includes a heating circuit and a temperature sensor. The sample entry orifice permits a sample of nucleic acid to enter the amplification chamber. The ingress is connected to a first conduit along with a pneumatic pump and a fluid pouch. The egress is connected to a second conduit permitting egress of the amplicon from the amplification chamber.Type: GrantFiled: December 15, 2006Date of Patent: April 22, 2014Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew MacLeod, Attila Csaba Nemeth, William Charles Dicke
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Patent number: 8389042Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: May 23, 2012Date of Patent: March 5, 2013Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20120270756Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: May 23, 2012Publication date: October 25, 2012Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8268604Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 20, 2007Date of Patent: September 18, 2012Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8241697Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: GrantFiled: December 20, 2007Date of Patent: August 14, 2012Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Patent number: 8048633Abstract: The invention relates to a method for the extraction of nucleic acid from cells, the amplification of segments of nucleic acid using modified primers, and the detection of nucleic acids.Type: GrantFiled: June 29, 2010Date of Patent: November 1, 2011Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Patent number: 8017340Abstract: The present invention relates to methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. In one embodiment, a sample comprising cells containing nucleic acid is exposed to an aqueous mixture comprising a lytic reagent and one or more beads capable of binding the nucleic acid released from said cells to form a nucleic acid-bead complex. The nucleic acid-bead complex is passed through an immiscible liquid layer to separate the nucleic acid from the aqueous mixture. The one or more beads are magnetic, and the nucleic acid-bead complex is passed through and separated from the immiscible liquid layer with an applied magnetic field. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: GrantFiled: July 29, 2010Date of Patent: September 13, 2011Assignee: Abbott Point of Care Inc.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100330575Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: June 29, 2010Publication date: December 30, 2010Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100297708Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.Type: ApplicationFiled: July 29, 2010Publication date: November 25, 2010Applicant: ABBOTT POINT OF CARE INC.Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100291666Abstract: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.Type: ApplicationFiled: December 21, 2005Publication date: November 18, 2010Inventors: Gordon Bruce Collier, John Allister Wood, Jason Andrew MacLeod, William Charles Dicke, Attila Csaba Nemeth, Cary James Miller
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Publication number: 20100255120Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: December 20, 2007Publication date: October 7, 2010Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20090159442Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.Type: ApplicationFiled: December 20, 2007Publication date: June 25, 2009Inventors: Gordon Bruce Collier, Jason Andrew Macleod, Anjulia Wong, Attila Csaba Nemeth
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Publication number: 20070154922Abstract: The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal, an egress with a second reversible seal, a sealable sample entry orifice, and a first wall forming a portion of the chamber. The first wall includes a thermally conductive material and includes an interior surface and an exterior surface. The exterior surface includes a heating circuit and a temperature sensor. The sample entry orifice permits a sample of nucleic acid to enter the amplification chamber. The ingress is connected to a first conduit along with a pneumatic pump and a fluid pouch. The egress is connected to a second conduit permitting egress of the amplicon from the amplification chamber.Type: ApplicationFiled: December 15, 2006Publication date: July 5, 2007Applicant: I-STAT CORPORATIONInventors: Gordon Bruce COLLIER, Jason Andrew MACLEOD, Attila Csaba NEMETH, William Charles DICKE