Abstract: Provided are computer-implemented systems and methods for simulating a reaction to a marketing message. A marketing message request including one or more marketing messages is received. A simulation profile is generated based on the marketing request and a plurality of healthcare professional profiles. A simulated reaction to the one or more marketing message is generated for a candidate healthcare professional profile of the plurality of healthcare professional profiles by sensing a first prompt including the candidate profile and the marketing message to an LLM system and receiving a first response based on the first prompt. The first response can include the simulated reaction from the candidate healthcare professional profile. The simulation profile is updated with the simulated reaction and the reaction is output.