Patents by Inventor Jason B. Alarcon
Jason B. Alarcon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9402974Abstract: A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.Type: GrantFiled: January 11, 2010Date of Patent: August 2, 2016Assignee: Becton, Dickinson and CompanyInventors: M. Ishaq Haider, Frank Martin, Bruce Clyde Roberts, Jason B. Alarcon
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Publication number: 20120041394Abstract: A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.Type: ApplicationFiled: January 11, 2010Publication date: February 16, 2012Applicant: BECTON, DICKINSON AND COMPANYInventors: M. Ishaq Haider, Frank Martin, Bruce Clyde Roberts, Jason B. Alarcon
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Patent number: 8075826Abstract: Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.Type: GrantFiled: June 18, 2009Date of Patent: December 13, 2011Assignee: Becton, Dickinson and CompanyInventors: Alexander G. Lastovich, Jason B. Alarcon, John P. Dekker, III, M. Ishaq Haider, John A. Mikszta, Frank E. Martin, Scott A. O'Connor
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Publication number: 20110159047Abstract: The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided.Type: ApplicationFiled: November 23, 2010Publication date: June 30, 2011Applicant: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, John A. Mikszta, Jason B. Alarcon, Matthew S. Ferriter, Joanne Huang, Ajit M. D'Souza
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Publication number: 20090304744Abstract: The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells.Type: ApplicationFiled: February 10, 2009Publication date: December 10, 2009Applicant: Becton, Dickinson and CompanyInventors: Robert L. Campbell, Kevin G. Dolan, Jason B. Alarcon, John A. Mikszta, Wendy Woodley, Sheetal Mehta
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Publication number: 20090299274Abstract: An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.Type: ApplicationFiled: August 7, 2009Publication date: December 3, 2009Applicant: BECTON, DICKINSON AND COMPANYInventors: Phillipe Laurent, John A. Mikszta, Jason B. Alarcon
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Publication number: 20090270792Abstract: Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.Type: ApplicationFiled: June 18, 2009Publication date: October 29, 2009Inventors: Alexander G. Lastovich, Jason B. Alarcon, John P. Dekker, III, M. Ishaq Haider, John A. Mikszta, Frank E. Martin, Scott A. O'Connor
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Patent number: 7582069Abstract: An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.Type: GrantFiled: November 19, 2007Date of Patent: September 1, 2009Assignee: Becton, Dickinson and CompanyInventors: Phillipe Laurent, John A. Mikszta, Jason B. Alarcon
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Patent number: 7473247Abstract: The present invention relates to methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.Type: GrantFiled: October 2, 2003Date of Patent: January 6, 2009Assignee: Becton, Dickinson and CompanyInventors: John A. Mikszta, Jason B. Alarcon, Cheryl Dean, Andrea Waterston
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Publication number: 20080226729Abstract: The present invention is directed to methods for preparing a stable powder formulation of an alum-adsorbed vaccine. The methods comprise atomizing a liquid formulation comprising an immunogen adsorbed onto an aluminum adjuvant to produce an atomized formulation, freezing the atomized formulation to produce frozen particles, and drying the frozen particles to produce dried powder particles. Pharmaceutical compositions comprising a stable powder formulation of an alum-adsorbed vaccine are also disclosed herein. The pharmaceutical compositions are stable at high temperatures and can be reconstituted in a pharmaceutically acceptable carrier to produce a reconstituted liquid vaccine that exhibits little or no particle agglomeration and retains immunogenicity. Methods of using the alum-adsorbed vaccine compositions for preventing and treating a disease in a subject, wherein the disease is associated with the particular immunogen, are further provided.Type: ApplicationFiled: September 10, 2007Publication date: September 18, 2008Applicant: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, John A. Mikszta, Jason B. Alarcon, Matthew S. Ferriter, Joanne Huang, Ajit M. D'Souza
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Patent number: 7422567Abstract: An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.Type: GrantFiled: August 27, 2003Date of Patent: September 9, 2008Assignee: Becton, Dickinson and CompanyInventors: Alexander G. Lastovich, Frank E. Martin, M. Ishaq Haider, Richard P. Clarke, Jason B. Alarcon, John A. Mikszta, John P. Dekker, III, Weston Harding
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Patent number: 7316671Abstract: Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.Type: GrantFiled: August 27, 2003Date of Patent: January 8, 2008Assignee: Becton, Dickinson and CompanyInventors: Alexander G. Lastovich, Jason B. Alarcon, John P. Dekker, III, M. Ishaq Haider, John A. Mikszta, Frank E. Martin, Scott A. O'Connor
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Patent number: 7316665Abstract: An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.Type: GrantFiled: August 25, 2004Date of Patent: January 8, 2008Assignee: Becton, Dickinson and CompanyInventors: Phillipe Laurent, John A. Mikszta, Jason B. Alarcon
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Patent number: 7166086Abstract: A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions which may be imparted by a spring device present in the microabrader device or the motion of the operator through the handle of the microabrader device. The device may further include system and methods for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The delivered substance may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.Type: GrantFiled: August 27, 2003Date of Patent: January 23, 2007Assignee: Becton, Dickinson and CompanyInventors: M. Ishaq Haider, Alexander G. Lastovich, Timothy J. Erskine, John A. Mikszta, Frank E. Martin, Scott A. O'Connor, Jason B. Alarcon, John P. Dekker, III
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Publication number: 20040143211Abstract: A method and device for the delivery of a substance into skin via the rotational movement of a microabrader device reduces the effects of operator variability. The method includes applying a substance to an area of a patient's skin through the rotational movement of microprotrusions. The movement of the microprotrusions can be imparted by a spring device or the like present in the microabrader device or the motion of the operator through the handle of the microabrader device. The rotational motion localizes the administration of the drug or vaccine dosage in the abraded skin area. The device can include means for monitoring pressure of the device against the skin and thereby promote consistency between applications and control of penetration depth. The substance, drug or vaccine may be placed on the microprotrusions and a reconstituting liquid included in the microabrader device.Type: ApplicationFiled: August 27, 2003Publication date: July 22, 2004Inventors: M. Ishaq Haider, Alexander G. Lastovich, Timothy J. Erskine, John A. Mikszta, Frank E. Martin, Scott A. O'Connor, Jason B. Alarcon, John P. Dekker
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Publication number: 20040131641Abstract: The present invention relates to methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.Type: ApplicationFiled: October 2, 2003Publication date: July 8, 2004Inventors: John A. Mikszta, Jason B. Alarcon, Cheryl Dean, Andrea Waterston
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Publication number: 20040120964Abstract: The present invention relates to a method of vaccinating a subject comprising delivering a chimeric yellow fever 17D strain vector expressing an envelope protein gene product of a heterologous flavivirus to the epidermal compartment or the intradermal compartment of the subject's skin. The invention encompasses vaccine compositions comprising the chimeric yellow fever viruses expressing an envelope protein gene product of a heterologous flavivirus. The compositions of the invention result in an enhanced therapeutic efficacy, e.g., enhanced protective immune response as they enhance the presentation and availability of the chimeric vaccine to the targeted compartment of the subject's skin.Type: ApplicationFiled: October 2, 2003Publication date: June 24, 2004Inventors: John A. Mikszta, Jason B. Alarcon, Cheryl Dean, Andrea Waterston, Farshad Guirakhoo, Monath P. Thomas
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Publication number: 20040077994Abstract: Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.Type: ApplicationFiled: August 27, 2003Publication date: April 22, 2004Inventors: Alexander G. Lastovich, Jason B. Alarcon, John P. Dekker, M. Ishaq Haider, John A. Mikszta, Frank E. Martin, Scott A. O'Connor
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Publication number: 20040064087Abstract: An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.Type: ApplicationFiled: August 27, 2003Publication date: April 1, 2004Inventors: Alexander G. Lastovich, Frank E. Martin, M. Ishaq Haider, Richard P. Clarke, Jason B. Alarcon, John A. Mitszka, John P. Dekker, Weston Harding
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Publication number: 20020198509Abstract: Methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.Type: ApplicationFiled: July 1, 2002Publication date: December 26, 2002Inventors: John A. Mikszta, Jason B. Alarcon, Paul G. Alchas