Abstract: There is provided a loudspeaker apparatus having: a first unit arranged to propagate sound in a first frequency range; and a second unit arranged to propagate sound in a second frequency range that is higher than the first frequency range. The first unit includes a sound-radiating member and the second unit is mounted to the sound-radiating member of the first unit. The first unit and the second unit are driven by separate audio channels and/or the sound-radiating member of the first unit is planar.

Abstract: A coaxial loudspeaker apparatus (10) comprising: a first unit, being arranged to propagate sound in a first frequency range; a second unit, being arranged to propagate sound in a second frequency range that is higher than the first frequency range, comprising a first waveguide (30); a second waveguide (60) arranged to extend substantially in prolongation of the first waveguide (30); and a third waveguide (100) arranged to extend substantially in prolongation of the second waveguide (60).

Abstract: A coaxial loudspeaker apparatus (10) comprising: a first unit, being arranged to propagate sound in a first frequency range; a second unit, being arranged to propagate sound in a second frequency range that is higher than the first frequency range, comprising a first waveguide (30); a second waveguide (60) arranged to extend substantially in prolongation of the first waveguide (30); and a third waveguide (100) arranged to extend substantially in prolongation of the second waveguide (60).

Abstract: A coaxial loudspeaker apparatus (10) comprising a first unit (20) being arranged to propagate sound in a first frequency range; a second unit comprising a first waveguide (30) arranged to propagate sound in a second frequency range that is higher than the first frequency range, and a second waveguide (60) arranged to move, during operation, relative to the first waveguide (30); wherein the second waveguide (60) extends substantially in prolongation of the first waveguide (30). The invention also extends to a loudspeaker (190) incorporating the coaxial loudspeaker apparatus (10).

Abstract: A heater-cooler system includes a plurality of heaters in thermal communication with a barrel of an extruder. The heater-cooler system includes a plurality of shroud assemblies that each define a cavity between a shroud assemblies and one of the heaters. Each heater is enclosed by one of the shroud assemblies. Each of the shroud assemblies has an intake port and an exhaust port. The heater-cooler system includes a blower connected to the intake port. The blower delivers air to the cavity. A portion of the each of the shroud assemblies at the exhaust port defines a flap moveably integrated therewith. The flap is opened by an increase in pressure in the cavity caused by operation of the blower. The flap seals the cavity in a closed position upon termination of blower operation. The flap is configured as a poppet valve.

Abstract: The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.

Abstract: Disclosed herein are methods of treating or inhibiting a pre-malignant condition, a benign neoplasia, or a virally-induced growth in a subject. The methods include administering a composition including an effective amount of one or more Stimulator of Interferon Genes (STING) agonists, or a pharmaceutically acceptable salt or prodrug thereof, to the subject. In particular embodiments, the methods include administering one or more STING agonists that are a cyclic dinucleotide or a derivative thereof to the subject, for example cyclic diadenylate monophosphate, cyclic diguanylate monophosphate, or a derivative thereof.

Abstract: A coaxial loudspeaker apparatus (10) comprising a first unit (20) being arranged to propagate sound in a first frequency range; a second unit comprising a first waveguide (30) arranged to propagate sound in a second frequency range that is higher than the first frequency range, and a second waveguide (60) arranged to move, during operation, relative to the first waveguide (30); wherein the second waveguide (60) extends substantially in prolongation of the first waveguide (30). The invention also extends to a loudspeaker (190) incorporating the coaxial loudspeaker apparatus (10).

Abstract: A heater-cooler system includes a plurality of heaters in thermal communication with a barrel of an extruder. The heater-cooler system includes a plurality of shroud assemblies that each define a cavity between a shroud assemblies and one of the heaters. Each heater is enclosed by one of the shroud assemblies. Each of the shroud assemblies has an intake port and an exhaust port. The heater-cooler system includes a blower connected to the intake port. The blower delivers air to the cavity. A portion of the each of the shroud assemblies at the exhaust port defines a flap moveably integrated therewith. The flap is opened by an increase in pressure in the cavity caused by operation of the blower. The flap seals the cavity in a closed position upon termination of blower operation. The flap is configured as a poppet valve.

Abstract: A heater-cooler system includes a plurality of heaters in thermal communication with a barrel of an extruder. The heater-cooler system includes a plurality of shroud assemblies that each define a cavity between a shroud assemblies and one of the heaters. Each heater is enclosed by one of the shroud assemblies. Each of the shroud assemblies has an intake port and an exhaust port. The heater-cooler system includes a blower connected to the intake port. The blower delivers air to the cavity. A portion of the each of the shroud assemblies at the exhaust port defines a flap moveably integrated therewith. The flap is opened by an increase in pressure in the cavity caused by operation of the blower. The flap seals the cavity in a closed position upon termination of blower operation.

Abstract: A first energy generating system comprises a ferromagnetic generator coupled to a voltage controlled switch. The ferromagnetic generator includes a ferromagnetic element generating a magnetic field and positioned within a pulse generating coil and near an explosive charge. Detonation of the explosive charge decreases the magnetic field and induces a pulse of electric energy in the pulse generating coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes. A second energy generating system comprises a flux compression generator coupled to a voltage controlled switch. The flux compression generator includes a inductance coil generating a magnetic field within a metallic armature that includes an explosive charge. Detonation of the explosive charge changes the magnetic field and induces a pulse of electric energy in the inductance coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes.

Abstract: A first energy generating system comprises a ferromagnetic generator coupled to a voltage controlled switch. The ferromagnetic generator includes a ferromagnetic element generating a magnetic field and positioned within a pulse generating coil and near an explosive charge. Detonation of the explosive charge decreases the magnetic field and induces a pulse of electric energy in the pulse generating coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes. A second energy generating system comprises a flux compression generator coupled to a voltage controlled switch. The flux compression generator includes a inductance coil generating a magnetic field within a metallic armature that includes an explosive charge. Detonation of the explosive charge changes the magnetic field and induces a pulse of electric energy in the inductance coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes.

Abstract: A first energy generating system comprises a ferromagnetic generator coupled to a voltage controlled switch. The ferromagnetic generator includes a ferromagnetic element generating a magnetic field and positioned within a pulse generating coil and near an explosive charge. Detonation of the explosive charge decreases the magnetic field and induces a pulse of electric energy in the pulse generating coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes. A second energy generating system comprises a flux compression generator coupled to a voltage controlled switch. The flux compression generator includes a inductance coil generating a magnetic field within a metallic armature that includes an explosive charge. Detonation of the explosive charge changes the magnetic field and induces a pulse of electric energy in the inductance coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes.

Abstract: A heater-cooler system for a barrel of an extruder is disclosed. The system includes a heater adapted to be in thermal communication with at least a portion of a barrel of an extruder. The system further includes a shroud assembly that defines a cavity. The shroud assembly encloses the heater. The shroud assembly has an intake port and an exhaust port. A valve is in fluid communication with the exhaust port. The valve is moveable between an open position and a closed position. When the valve is in the closed position the exhaust port is substantially sealed. When the valve is moved between the closed position and the open position or is in the open position the cavity is in fluid communication an area outside of the cavity through the exhaust port.

Abstract: The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.

Abstract: A first energy generating system comprises a ferromagnetic generator coupled to a voltage controlled switch. The ferromagnetic generator includes a ferromagnetic element generating a magnetic field and positioned within a pulse generating coil and near an explosive charge. Detonation of the explosive charge decreases the magnetic field and induces a pulse of electric energy in the pulse generating coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes. A second energy generating system comprises a flux compression generator coupled to a voltage controlled switch. The flux compression generator includes a inductance coil generating a magnetic field within a metallic armature that includes an explosive charge. Detonation of the explosive charge changes the magnetic field and induces a pulse of electric energy in the inductance coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes.

Abstract: A first energy generating system comprises a ferromagnetic generator coupled to a voltage controlled switch. The ferromagnetic generator includes a ferromagnetic element generating a magnetic field and positioned within a pulse generating coil and near an explosive charge. Detonation of the explosive charge decreases the magnetic field and induces a pulse of electric energy in the pulse generating coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes. A second energy generating system comprises a flux compression generator coupled to a voltage controlled switch. The flux compression generator includes a inductance coil generating a magnetic field within a metallic armature that includes an explosive charge. Detonation of the explosive charge changes the magnetic field and induces a pulse of electric energy in the inductance coil. When the magnitude of the electric energy reaches a certain level, the voltage controlled switch closes.

Abstract: A ferroelectric energy generator system comprises an explosive unit, a ferroelectric element, a first and a second output terminal, and a voltage-controlled switch. The explosive unit may include an explosive charge and a detonator which in combination may supply a shock wave. The ferroelectric element may include a third output terminal coupled to the voltage-controlled switch and a fourth output terminal coupled to the second output terminal. Upon receiving the shock wave, the ferroelectric element may be compressed and depolarized and, as a result, may generate a pulse of voltage between the third and the fourth output terminals. When the voltage reaches a breakdown level, the voltage-controlled switch may close and quickly deliver electric current to a load coupled to the ferroelectric energy generator system.

Abstract: A ferroelectric energy generator system comprises an explosive unit, a ferroelectric element, a first and a second output terminal, and a voltage-controlled switch. The explosive unit may include an explosive charge and a detonator which in combination may supply a shock wave. The ferroelectric element may include a third output terminal coupled to the voltage-controlled switch and a fourth output terminal coupled to the second output terminal. Upon receiving the shock wave, the ferroelectric element may be compressed and depolarized and, as a result, may generate a pulse of voltage between the third and the fourth output terminals. When the voltage reaches a breakdown level, the voltage-controlled switch may close and quickly deliver electric current to a load coupled to the ferroelectric energy generator system.