Abstract: A method for creating a tract for percutaneous endoscopic guided gastrointestinal tube creation including the steps of providing a puncture wire having a sharp tissue penetrating tip shielded in a sheath, the puncture wire slidable within the sheath and releasably lockingly engaged thereto; inserting the puncture wire and sheath in a first direction through a working channel of an endoscope to exit the channel of the endoscope, then releasing the puncture wire from the sheath and advancing the puncture wire from the sheath while visualizing via the endoscope the position of the puncture wire, and further advancing the puncture wire through the visceral wall and then the abdominal wall of a patient. Subsequent methods to position a percutaneous gastrointestinal catheter after initial wire puncture are described.

Abstract: A method for creating a tract in retrograde fashion for nephrostomy tube creation comprising the steps of providing a puncture wire having a tissue penetrating tip shielded in a sheath, inserting the puncture wire and sheath through a channel in an ureteroscope, advancing the puncture wire from the sheath while visualizing under direct vision a position of the puncture wire, advancing the puncture wire through a selected calyx, and inserting antegrade a coaxial catheter over the puncture wire.

Abstract: A method for creating a tract for nephrostomy tube creation comprising the steps of providing a puncture wire having a tissue penetrating tip shielded in a sheath, the puncture wire slidable within the sheath and releasably lockingly engaged thereto, inserting the puncture wire and sheath in a first direction through a working channel of an ureteroscope to exit the channel of the ureteroscope, releasing the puncture wire from the sheath and advancing the puncture wire a first distance from the sheath while visualizing via the ureteroscope the position of the puncture wire, advancing the puncture wire and the sheath into a selected calyx and through a flank of a patient, removing the puncture wire from the sheath in a second direction different from the first direction and inserting a guidewire through the sheath.

Abstract: This invention generally relates to a composition comprising an enriched NK cell population. The invention further relates to a method of treating a solid tumor or a hyperproliferative disorder by administering the enriched NK cell population to a mammalian subject in need thereof.

Abstract: A method for creating a tract in retrograde fashion for nephrostomy tube creation comprising the steps of providing a puncture wire having a tissue penetrating tip shielded in a sheath, inserting the puncture wire and sheath through a channel in an ureteroscope, advancing the puncture wire from the sheath while visualizing under direct vision a position of the puncture wire, advancing the puncture wire through a selected calyx, and inserting antegrade a coaxial catheter over the puncture wire.

Abstract: A method for creating a tract for nephrostomy tube creation comprising the steps of providing a puncture wire having a tissue penetrating tip shielded in a sheath, the puncture wire slidable within the sheath and releasably lockingly engaged thereto, inserting the puncture wire and sheath in a first direction through a working channel of an ureteroscope to exit the channel of the ureteroscope, releasing the puncture wire from the sheath and advancing the puncture wire a first distance from the sheath while visualizing via the ureteroscope the position of the puncture wire, advancing the puncture wire and the sheath into a selected calyx and through a flank of a patient, removing the puncture wire from the sheath in a second direction different from the first direction and inserting a guidewire through the sheath.

Abstract: A transparent outer covering used in a co-axial metallic ureteric stent for deployment of the lower tip of the metallic ureteric stent in relation to the ureteric orifice. Exact positioning of the stent is critical to avoid complications and ensure proper functioning of the stent. Stent is deployed from within outer sheath in a coaxial system. The function of the coaxial outer sheath is to provide a straight channel for deployment and positioning of the curl-tipped metal stent (double-J stent). Without the outer sheath it would simply not be possible to advance the flexible, curl-tipped metal stent into the kidney. Surgeon controls a ureteric catheter ‘pusher’ whose tip is advanced against the lower tip of the metal stent within the OPAQUE sheath, Deployment is achieved by withdrawing the OPAQUE outer sheath, while holding stent/ureteric catheter in static position.

Abstract: The invention generally relates to a composition comprising an enriched NK cell population. The invention further relates to a method of treating a solid tumor or a hyperproliferative disorder by administering the enriched NK cell population to a mammalian subject in need thereof.