Patent number: 9673407
Abstract: A compound including a ligand L according to Formula I: as well as, a first device and a formulation containing the same, are disclosed. In the compound including the Ligand L of Formula I: R1 and R2 are independently selected from group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, cyano, and combinations thereof; two adjacent substituents of R1 or R2 are optionally joined to form a fused ring; ligand L is coordinated to transition metal M having an atomic number greater than 40; R1 represent mono, di, tri, or tetra-substitution, or no substitution; R2 represent mono, di, or tri-substitution, or no substitution; and at least one substituent of R1 or R2 is cyano.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
June 6, 2017
Assignee:
UNIVERSAL DISPLAY CORPORATION
Inventors:
Geza Szigethy, Christopher B. Murray, Jason Brooks
Patent number: 9590195
Abstract: A compound including a Ligand L of Formula I: as well as, a first device and a formulation containing the same, are disclosed. In the compound including the Ligand L of Formula I: X is selected from the group consisting of S, Se, SiRR? and GeRR?; R1, R2, R, and R? are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; any adjacent substitutions or substituents of R1, R2, R, and R? are optionally linked together to form a ring; the Ligand L is coordinated to a metal M having an atomic number of 40 or greater; and the Ligand L is optionally linked with other ligands to comprise a tridentate, tetradentate, pentadentate or hexadentate ligand.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
March 7, 2017
Assignee:
UNIVERSAL DISPLAY CORPORATION
Inventors:
Geza Szigethy, Jason Brooks
Patent number: 9556135
Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.
Type:
Grant
Filed:
October 10, 2013
Date of Patent:
January 31, 2017
Assignee:
Amgen, Inc.
Inventors:
Richard T. Lewis, Jennifer R. Allen, Yuan Cheng, Deborah Choquette, Oleg Epstein, Angel Guzman-Perez, Paul E. Harrington, Zihao Hua, Randall W. Hungate, Jason Brooks Human, Ted Judd, Qingyian Liu, Patricia Lopez, Ana Elena Minatti, Philip Olivieri, Karina Romero, Shannon Rumfelt, Robert M. Rzasa, Laurie Schenkel, John Stellwagen, Ryan White, Qiufen Xue, Xiao Mei Zheng, Wenge Zhong