Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: A content delivery network may provide content items to requesting devices using a popularity-based distribution hierarchy. A central analysis system may determine popularity data for a content item stored in a first caching device. The central analysis system may determine that a change in the popularity data is beyond a threshold value. The central analysis system may then transmit an instruction to move the content item from the first caching device to a second caching device in a different tier of caching devices than the first caching device. The central analysis system may update a content index to indicate that the content item has been moved to the second caching device. A user device may be redirected to request the content item directly from the second caching device.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: A content delivery network may provide content items to requesting devices using a popularity-based distribution hierarchy. A central analysis system may determine popularity data for a content item stored in a first caching device. The central analysis system may determine that a change in the popularity data is beyond a threshold value. The central analysis system may then transmit an instruction to move the content item from the first caching device to a second caching device in a different tier of caching devices than the first caching device. The central analysis system may update a content index to indicate that the content item has been moved to the second caching device. A user device may be redirected to request the content item directly from the second caching device.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: A resource management system may use information regarding the bandwidth status of a downstream communication path to determine what portion of queued content should be sent in the current available bandwidth timeslot. In some embodiments, multiple versions of the same requested content may be available, and the system may select a lower-quality version to send if needed to meet a time deadline included in the original content request.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.

Abstract: Systems and methods for managing the storage and delivery of recorded content in a network digital video recorder (DVR) system are disclosed. A plurality of requests to record a program may be received, wherein the program may comprise a plurality of segments. A segment from the plurality of segments may be determined to be copied to a first storage. A copy of the segment may be received from a second storage and a plurality of copies of the segment may be created in the first storage from the copy of the segment received from the second storage. The quantity of the plurality of copies of the segment may be equal to the quantity of the plurality of requests to record the program.

Abstract: Systems and methods for managing the storage and delivery of recorded content in a network digital video recorder (DVR) system are disclosed. A plurality of requests to record a program may be received, wherein the program may comprise a plurality of segments. A segment from the plurality of segments may be determined to be copied to a first storage. A copy of the segment may be received from a second storage and a plurality of copies of the segment may be created in the first storage from the copy of the segment received from the second storage. The quantity of the plurality of copies of the segment may be equal to the quantity of the plurality of requests to record the program.

Abstract: A content delivery network may provide content items to requesting devices using a popularity-based distribution hierarchy. A central analysis system may determine popularity data for a content item stored in a first caching device. The central analysis system may determine that a change in the popularity data is beyond a threshold value. The central analysis system may then transmit an instruction to move the content item from the first caching device to a second caching device in a different tier of caching devices than the first caching device. The central analysis system may update a content index to indicate that the content item has been moved to the second caching device. A user device may be redirected to request the content item directly from the second caching device.

Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.

Abstract: Systems and methods for managing the storage and delivery of recorded content in a network digital video recorder (DVR) system are disclosed. A plurality of requests to record a program may be received, wherein the program may comprise a plurality of segments. A segment from the plurality of segments may be determined to be copied to a first storage. A copy of the segment may be received from a second storage and a plurality of copies of the segment may be created in the first storage from the copy of the segment received from the second storage. The quantity of the plurality of copies of the segment may be equal to the quantity of the plurality of requests to record the program.

Abstract: Systems and methods for managing the storage of content are described. A video stream may include a content identifier and content information relating to a boundary that may be used to facilitate recording of at least a portion of the video stream.