Abstract: Some examples described herein relate to producing an optimized composition of a downhole drilling fluid. For example, a system can execute an iterative optimization process to determine an optimized composition of downhole drilling fluid that satisfies at least one objective function and matches a received set of target fluid properties. Each iteration of the iterative optimization process can involve: selecting a mixture of fluid components for the downhole drilling fluid from a search space, providing the selected mixture of fluid components as input to a trained machine-learning model, receiving a set of predicted fluid properties for the mixture of fluid components as output from the trained machine-learning model, and determining whether the set of predicted fluid properties matches the set of target fluid properties. The system can transmit a control signal to a mixing subsystem for causing the mixing subsystem to produce the optimized composition of the downhole drilling fluid.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage is disclosed. The fuselage contains a continuous interior cargo bay, and includes a forward portion, an aft portion, and a kinked portion forming a junction in the fuselage between the forward and aft portions. The kinked portion contains a transition region of the cargo bay and defines a bend between a forward centerline and an aft centerline. The kinked portion is formed with a forward transverse frame section, a separate aft transverse frame section, and a plurality of longitudinal frame elements extending between the forward and aft frame sections, the forward frame being coupled to an aft end of the forward portion and the aft frame section being coupled to a forward end of the aft portion such that the aft frame section is angled with respect to the forward frame section about a lateral axis of the cargo aircraft.

Abstract: Systems and methods for loading a cargo aircraft are described. The system includes at least one rail disposed in an interior cargo bay of a cargo aircraft that extends at an angle relative to an interior bottom contact surface of a forward portion of the interior cargo bay, through a kinked portion and an aft portion of the interior cargo bay. Payload-receiving fixtures are described that can be used in conjunction with the rail system, allowing for large cargo, such as wind turbine blades, to be transported by aircraft. Methods of loading a cargo aircraft can include advancing the large payload into the interior cargo bay of the aircraft such that at least one of the payload-receiving fixtures rises relative to a plane defined by the interior bottom contact surface of the forward portion of the interior cargo bay. Various systems, methods, components, and related tooling are also provided.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage to extend the useable length of a continuous interior cargo bay while still meeting a tailstrike requirement is disclosed. The fuselage defines a continuous interior cargo bay along a majority of its length and a pitch axis about which the cargo aircraft rotates during takeoff while still on the ground. The fuselage includes a forward portion defining longitudinal-lateral plane of the cargo aircraft an aft portion extending aft from the pitch axis to the aft end and containing an aft region of the continuous interior cargo bay that extends along a majority of a length of the aft portion. The aft portion has a centerline extending above the forward upper surface of the aircraft.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage is disclosed. The fuselage contains a continuous interior cargo bay, and includes a forward portion, an aft portion, and a kinked portion forming a junction in the fuselage between the forward and aft portions. The kinked portion contains a transition region of the cargo bay and defines a bend between a forward centerline and an aft centerline. The kinked portion is formed with a forward transverse frame section, a separate aft transverse frame section, and a plurality of longitudinal frame elements extending between the forward and aft frame sections, the forward frame being coupled to an aft end of the forward portion and the aft frame section being coupled to a forward end of the aft portion such that the aft frame section is angled with respect to the forward frame section about a lateral axis of the cargo aircraft.

Abstract: The present disclosure provides methods, compositions, and systems for selective enzymatic gelation of cells, e.g., immune cells, contained in partitions.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage is disclosed. The fuselage contains a continuous interior cargo bay, and includes a forward portion, an aft portion, and a kinked portion forming a junction in the fuselage between the forward and aft portions. The kinked portion contains a transition region of the cargo bay and defines a bend between a forward centerline and an aft centerline. The kinked portion is formed with a forward transverse frame section, a separate aft transverse frame section, and a plurality of longitudinal frame elements extending between the forward and aft frame sections, the forward frame being coupled to an aft end of the forward portion and the aft frame section being coupled to a forward end of the aft portion such that the aft frame section is angled with respect to the forward frame section about a lateral axis of the cargo aircraft.

Abstract: The present disclosure provides methods, systems, and kits for processing nucleic acid molecules. A method may comprise providing a template nucleic acid fragment (e.g., within a cell, cell bead, or cell nucleus) within a partition (e.g., a droplet or well) and subjecting the template nucleic acid fragment to one or more processes including a barcoding process and a single primer extension or amplification process. The processed template nucleic acid fragment may then be recovered from the partition and subjected to further amplification to provide material for subsequent sequencing analysis. The methods provided herein may permit simultaneous processing and analysis of both DNA and RNA molecules originating from the same cell, cell bead, or cell nucleus.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage is disclosed. The fuselage contains a continuous interior cargo bay, and includes a forward portion, an aft portion, and a kinked portion forming a junction in the fuselage between the forward and aft portions. The kinked portion contains a transition region of the cargo bay and defines a bend between a forward centerline and an aft centerline. The kinked portion is formed with a forward transverse frame section, a separate aft transverse frame section, and a plurality of longitudinal frame elements extending between the forward and aft frame sections, the forward frame being coupled to an aft end of the forward portion and the aft frame section being coupled to a forward end of the aft portion such that the aft frame section is angled with respect to the forward frame section about a lateral axis of the cargo aircraft.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage is disclosed. The fuselage contains a continuous interior cargo bay, and includes a forward portion, an aft portion, and a kinked portion forming a junction in the fuselage between the forward and aft portions. The kinked portion contains a transition region of the cargo bay and defines a bend between a forward centerline and an aft centerline. The kinked portion is formed with a forward transverse frame section, a separate aft transverse frame section, and a plurality of longitudinal frame elements extending between the forward and aft frame sections, the forward frame being coupled to an aft end of the forward portion and the aft frame section being coupled to a forward end of the aft portion such that the aft frame section is angled with respect to the forward frame section about a lateral axis of the cargo aircraft.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: Systems and methods for loading a cargo aircraft are described. The system includes at least one rail disposed in an interior cargo bay of a cargo aircraft that extends at an angle relative to an interior bottom contact surface of a forward portion of the interior cargo bay, through a kinked portion and an aft portion of the interior cargo bay. Payload-receiving fixtures are described that can be used in conjunction with the rail system, allowing for large cargo, such as wind turbine blades, to be transported by aircraft. Methods of loading a cargo aircraft can include advancing the large payload into the interior cargo bay of the aircraft such that at least one of the payload-receiving fixtures rises relative to a plane defined by the interior bottom contact surface of the forward portion of the interior cargo bay. Various systems, methods, components, and related tooling are also provided.

Abstract: Systems and methods for loading a cargo aircraft are described. The system includes at least one rail disposed in an interior cargo bay of a cargo aircraft that extends at an angle relative to an interior bottom contact surface of a forward portion of the interior cargo bay, through a kinked portion and an aft portion of the interior cargo bay. Payload-receiving fixtures are described that can be used in conjunction with the rail system, allowing for large cargo, such as wind turbine blades, to be transported by aircraft. Methods of loading a cargo aircraft can include advancing the large payload into the interior cargo bay of the aircraft such that at least one of the payload-receiving fixtures rises relative to a plane defined by the interior bottom contact surface of the forward portion of the interior cargo bay. Various systems, methods, components, and related tooling are also provided.

Abstract: A fixed-wing cargo aircraft having a kinked fuselage to extend the useable length of a continuous interior cargo bay while still meeting a tailstrike requirement is disclosed. The fuselage defines a continuous interior cargo bay along a majority of its length and a pitch axis about which the cargo aircraft rotates during takeoff while still on the ground. The fuselage includes a forward portion defining longitudinal-lateral plane of the cargo aircraft an aft portion extending aft from the pitch axis to the aft end and containing an aft region of the continuous interior cargo bay that extends along a majority of a length of the aft portion. The aft portion has a centerline extending above the forward upper surface of the aircraft.

Abstract: Methods of determining a final space reservation for a new aircraft are disclosed. The methods include using parametric definitions of potential payloads to generate a population of representative payloads for use in creating an initial space reservation. The methods include accounting for and applying a variety of margins on each potential payload and taking the union of potential payloads. Alternatively, the union can be taken first and then the margins applied. A homogenous space reservation can be determined based upon a variety of differently shaped or sized payloads, including a margin build-up to mitigate risk of unknowns associated with future changes in specific payload shapes and sizes, build tolerances, environmental conditions, and/or loading and unloading motions and clearances. Once this space reservation is known, it is possible to design an external shape of a carrying vehicle by staying outside of this space reservation.

Abstract: Systems and methods for loading a cargo aircraft are described. The system includes at least one rail disposed in an interior cargo bay of a cargo aircraft that extends at an angle relative to an interior bottom contact surface of a forward portion of the interior cargo bay, through a kinked portion and an aft portion of the interior cargo bay. Payload-receiving fixtures are described that can be used in conjunction with the rail system, allowing for large cargo, such as wind turbine blades, to be transported by aircraft. Methods of loading a cargo aircraft can include advancing the large payload into the interior cargo bay of the aircraft such that at least one of the payload-receiving fixtures rises relative to a plane defined by the interior bottom contact surface of the forward portion of the interior cargo bay. Various systems, methods, components, and related tooling are also provided.