Patents by Inventor Jason C. KLIMA

Jason C. KLIMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • De Novo Design of Immunoglobulin-like Domains
    Publication number: 20230279055
    Abstract: The disclosure provides antibody-like polypeptides of the formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15, wherein the domains are as defined herein, nucleic acids encoding the polypeptides, and methods for use and design of the polypeptides.
    Type: Application
    Filed: March 2, 2023
    Publication date: September 7, 2023
    Inventors: David Baker, Tamuka Chidyausiku, Jason C. Klima, Enrique Marcos Benteo, F. Xavier Gomis Rüth, Soraia Dos Reis Mendes, Ulrich Eckhard, Marta Nadal Rovira, Jorge Luis Roel Touris
  • MULTIPARTITE AND CIRCULARLY PERMUTED BETA-BARREL POLYPEPTIDES AND METHODS FOR THEIR USE
    Publication number: 20230065495
    Abstract: Disclosed herein are ?-barrel polypeptides including self-complementing multipartite ?-barrel polypeptides and circularly permuted ?-barrel polypeptides and methods for their design and use in mediating real-time monitoring of polypeptide-polypeptide association and dissociation events.
    Type: Application
    Filed: February 5, 2021
    Publication date: March 2, 2023
    Inventors: Jason C. KLIMA, David BAKER
  • METALLOENZYMES FOR BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES
    Publication number: 20220283175
    Abstract: The present disclosure relates to a metalloprotein binder that specifically binds to a N-terminally modified peptide. Also provided herein is a method and related kits for treating or analyzing a peptide using the metalloprotein binder and/or modified cleavase. In some embodiments, the method provided herein comprises binding metalloprotein binder-coding tag conjugates to a modified N-terminal amino acid residue of an immobilized peptide associated with a recording tag, transferring identifying information from the coding tag to the recording tag using a ligation or primer extension, and cleaving the modified N-terminal amino acid residue. The method and metalloprotein binders provided herein are useful for de novo peptide identification or sequencing.
    Type: Application
    Filed: April 22, 2022
    Publication date: September 8, 2022
    Applicant: Encodia, Inc.
    Inventors: Eric OKERBERG, Stephen VERESPY, III, Jason C. KLIMA, Soumya GANGULY, Zachary MILES, Jason Duarte JACINTHO, Aaron WISE
  • DE NOVO DESIGN OF TUNABLE PH-DRIVEN CONFORMATIONAL SWITCHES
    Publication number: 20220144895
    Abstract: Disclosed herein are polypeptides or polypeptide oligomers, including a buried hydrogen bond network that includes at least (1, 2, 3, 4, 5, 6, 7, 8, or 9) pH sensitive amino acids located (i) at an intra-chain interface between different: structural elements in one polypeptide, or (it) at an inter-chain interface between structural elements present in different chains of a polypeptide oligomer, wherein the polypeptide or polypeptide oligomer is stable above a given pH, and wherein the polypeptide or polypeptide oligomer undergoes a conformational transition when subjected to a pH at or below the given pH.
    Type: Application
    Filed: April 20, 2020
    Publication date: May 12, 2022
    Inventors: Scott BOYKEN, David BAKER, Zibo CHEN, Alfredo Quijano RUBIO, Neil P. KING, Jason C. KLIMA, Carl WALKEY
  • BETA BARREL POLYPEPTIDES AND METHODS FOR THEIR USE
    Publication number: 20210047373
    Abstract: Disclosed herein are de novo designed beta barrel polypeptides, methods for designing such polypeptides, and methods for their use.
    Type: Application
    Filed: April 4, 2019
    Publication date: February 18, 2021
    Inventors: Jiayi DOU, Anastassia VOROBIEVA, Jason C. KLIMA, David BAKER