Patents by Inventor Jason C. Reed
Jason C. Reed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10802012Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: GrantFiled: October 5, 2017Date of Patent: October 13, 2020Assignee: The Regents of the University of CaliforniaInventors: James K. Gimzewski, Jason C. Reed, Michael A. Teitell
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Publication number: 20200224255Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon.Type: ApplicationFiled: January 10, 2020Publication date: July 16, 2020Inventors: James K. Gimzewski, Bhubaneswar Mishra, Jason C. Reed
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Patent number: 10570442Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon.Type: GrantFiled: September 24, 2013Date of Patent: February 25, 2020Assignees: New York University, The Regents of the University of CaliforniaInventors: James K. Gimzewski, Bhubaneswar Mishra, Jason C. Reed
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Patent number: 10203331Abstract: A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.Type: GrantFiled: August 2, 2012Date of Patent: February 12, 2019Assignee: The Regents of the University of CaliforniaInventors: Jason C. Reed, Michael A. Teitell
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Patent number: 9995766Abstract: The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.Type: GrantFiled: June 16, 2010Date of Patent: June 12, 2018Assignee: The Regents of the University of CaliforniaInventors: Jason C. Reed, Bhubaneswar Mishra, Andrew Sundstrom
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Publication number: 20180156779Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: ApplicationFiled: October 5, 2017Publication date: June 7, 2018Inventors: James K. Gimzewski, Jason C. Reed, Michael A. Teitell
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Patent number: 9810683Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: GrantFiled: November 25, 2013Date of Patent: November 7, 2017Assignee: The Regents of the University of CaliforniaInventors: James K. Gimzewski, Jason C. Reed, Michael A. Teitell
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Publication number: 20140178865Abstract: A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.Type: ApplicationFiled: August 2, 2012Publication date: June 26, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jason C. Reed, Michael A. Teitell
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Publication number: 20140170647Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using scanning probe microscopy, to detect the analyte. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon.Type: ApplicationFiled: September 24, 2013Publication date: June 19, 2014Applicants: New York University, The Regents of the University of CaliforniaInventors: James K. Gimzewski, Bhubaneswar Mishra, Jason C. Reed
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Publication number: 20140080171Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: ApplicationFiled: November 25, 2013Publication date: March 20, 2014Applicant: The Regents of the University of CaliforniaInventors: James K. Gimzewski, Jason C. Reed, Michael A. Teitell
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Patent number: 8599383Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: GrantFiled: May 6, 2009Date of Patent: December 3, 2013Assignee: The Regents of the University of CaliforniaInventors: Michael A. Teitell, James K. Gimzewski, Jason C. Reed
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Patent number: 8566038Abstract: The present invention provides methods of detecting a nucleic acid analyte in a sample. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.Type: GrantFiled: October 17, 2006Date of Patent: October 22, 2013Assignees: The Regents of the University of California, New York UniversityInventors: James K. Gimzewski, Bhubaneswar Mishra, Jason C. Reed
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Publication number: 20110013820Abstract: The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.Type: ApplicationFiled: June 16, 2010Publication date: January 20, 2011Inventors: Jason C. Reed, Bhubaneswar Mishra, Andrew Sundstrom
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Publication number: 20100284016Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.Type: ApplicationFiled: May 6, 2009Publication date: November 11, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Michael A. Teitell, James K. Gimzewski, Jason C. Reed
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Patent number: 5445095Abstract: A process for reducing skin friction and inhibiting the effects of liquid turbulence in a system involving the flow of a liquid along the surface of a body, e.g. a marine vehicle, includes injecting a drag reducing polymer into the valleys of adjacent, evenly spaced, longitudinal grooves extending along the length of the surface of the body, so that the rate of diffusion of the polymer from individual grooves into the liquid flow is predictably controlled by the groove dimensions. When the polymer has diffused over the tips of the grooves into the near wall region of the boundary layer, the polymer effectively reduces the turbulent skin friction. A substantial drag reducing effect is achieved with less polymer than must be used to lower skin friction when the surface of the body is smooth.Type: GrantFiled: May 28, 1992Date of Patent: August 29, 1995Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Jason C. Reed, Dennis M. Bushnell
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Patent number: 5054412Abstract: A process for reducing skin friction, inhibiting the effects of liquid turbulence, and decreasing heat transfer in a system involving flow of a liquid along a surface of a body includes applying a substantially integral sheet of a gas, e.g., air, immediately adjacent to the surface of the body, e.g., a marine vehicle, which has a longitudinally grooved surface in proximity with the liquid and with a surface material having high contact angle between the liquid and said wall to reduce interaction of the liquid, e.g., water, with the surface of the body, e.g., the hull of the marine vehicle.Type: GrantFiled: October 31, 1989Date of Patent: October 8, 1991Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Jason C. Reed, Dennis M. Bushnell, Leonard M. Weinstein