Patents by Inventor Jason Christiansen
Jason Christiansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11845138Abstract: A method for repairing a pocket of a case for a variable stator assembly may comprise: receiving, via a processor, a plurality of wear depths, each wear depth in the plurality of wear depths corresponding to a wear portion in a stator pocket in a plurality of stator pockets; determining, via the processor, a plurality of thicknesses of a coating to be deposited based on the plurality of wear depths, each thickness of the coating in the plurality of thicknesses corresponding to the wear portion for each stator pocket in the plurality of stator pockets; and commanding, via the processor, a coating spray torch to deposit the coating in the wear portion of each stator pocket in the plurality of stator pockets.Type: GrantFiled: March 2, 2021Date of Patent: December 19, 2023Assignee: RTX CORPORATIONInventors: Heather Danielsen, Norman Gagnon, George Reynolds, Kevin Sloan, Keith Pooler, Jason Christiansen, Michael Fischer
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Publication number: 20230248728Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.Type: ApplicationFiled: March 24, 2023Publication date: August 10, 2023Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary D. HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
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Patent number: 11642345Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.Type: GrantFiled: October 21, 2022Date of Patent: May 9, 2023Assignee: BOUNDLESS BIO, INC.Inventors: Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
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Publication number: 20230124417Abstract: Methods and systems for quantitation of features of interest (e.g., extrachromosomal DNA) in whole slide images are disclosed herein. One or more methods and systems described herein are used to reduce bias in the quantitation of the features of interest.Type: ApplicationFiled: March 15, 2021Publication date: April 20, 2023Inventors: Nam-Phuong NGUYEN, Eva Lorena MORA-BLANCO, Kristen TURNER, Julie WIESE, Jason CHRISTIANSEN, Mihir BAFNA
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Publication number: 20230104315Abstract: Provided herein are methods and systems for detecting ecDNA positive cancers and methods and systems for developing signatures of ecDNA positive cancers.Type: ApplicationFiled: March 25, 2021Publication date: April 6, 2023Inventors: Nam-Phuong NGUYEN, Jason CHRISTIANSEN, Laurence JADIN
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Publication number: 20230078903Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.Type: ApplicationFiled: October 21, 2022Publication date: March 16, 2023Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
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Patent number: 11547711Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.Type: GrantFiled: January 4, 2022Date of Patent: January 10, 2023Assignee: BOUNDLESS BIO, INC.Inventors: Christian Hassig, Ryan Hansen, Snezana Milutinovic, Jason Christiansen, Zachary Hornby, Sudhir Chowdhry, Anthony Celeste, Kristen Turner, Deepti Wilkinson
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Publication number: 20220281025Abstract: A method for repairing a pocket of a case for a variable stator assembly may comprise: receiving, via a processor, a plurality of wear depths, each wear depth in the plurality of wear depths corresponding to a wear portion in a stator pocket in a plurality of stator pockets; determining, via the processor, a plurality of thicknesses of a coating to be deposited based on the plurality of wear depths, each thickness of the coating in the plurality of thicknesses corresponding to the wear portion for each stator pocket in the plurality of stator pockets; and commanding, via the processor, a coating spray torch to deposit the coating in the wear portion of each stator pocket in the plurality of stator pockets.Type: ApplicationFiled: March 2, 2021Publication date: September 8, 2022Applicant: Raytheon Technologies CorporationInventors: Heather Danielsen, Norman Gagnon, George Reynolds, Kevin Sloan, Keith Pooler, Jason Christiansen, Michael Fischer
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Publication number: 20220143022Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.Type: ApplicationFiled: January 4, 2022Publication date: May 12, 2022Inventors: Christian HASSIG, Ryan HANSEN, Snezana MILUTINOVIC, Jason CHRISTIANSEN, Zachary HORNBY, Sudhir CHOWDHRY, Anthony CELESTE, Kristen TURNER, Deepti WILKINSON
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Publication number: 20190391164Abstract: The present technology relates generally to determining a risk of recurrence of disease in a cancer patient. In particular, this approach to determining a risk of recurrence involves utilizing standardized quantitative assessments of the level of biomarker expression selected from estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 (Ki67) in a patient's tumor to determine the risk of recurrence, thereby allowing a caretaker to determine the best course of treatment for the patient.Type: ApplicationFiled: September 6, 2019Publication date: December 26, 2019Applicant: Novartis AGInventors: Mark D. Gustavson, Jason Christiansen
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Patent number: 10408846Abstract: The present technology relates generally to determining a risk of recurrence of disease in a cancer patient. In particular, this approach to determining a risk of recurrence involves utilizing standardized quantitative assessments of the level of biomarker expression selected from estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 (Ki67) in a patient's tumor to determine the risk of recurrence, thereby allowing a caretaker to determine the best course of treatment for the patient.Type: GrantFiled: March 15, 2013Date of Patent: September 10, 2019Assignee: Novartis AGInventors: Mark D. Gustavson, Jason Christiansen
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Patent number: 9240043Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.Type: GrantFiled: September 15, 2009Date of Patent: January 19, 2016Assignee: NOVARTIS AGInventors: Jason Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Gregory R. Tedeschi, Dylan M. Reilly, Maciej P. Zerkowski, Christine Williams, Dongxiao Wang
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Patent number: 9080978Abstract: Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.Type: GrantFiled: April 22, 2013Date of Patent: July 14, 2015Assignee: Novartis AGInventors: Jason Christiansen, Robert Pinard, Maciej P. Zerkowski, Gregory R. Tedeschi
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Patent number: 8878983Abstract: The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.Type: GrantFiled: May 27, 2011Date of Patent: November 4, 2014Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Dylan M. Reilly, Brian Bourke-Martin, Mark Gustavson
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Publication number: 20130344510Abstract: Disclosed herein are methods of identifying suitable patients for postoperative radiotherapy based on the discovery that the quantification of ER, beyond simple positive/negative characterization, can provide valuable predictive information for the treatment of cancer, specifically breast cancer, and more particularly may predict a group more likely to respond to RT and spare patients from a potentially harmful treatment. Furthermore, the true quantification of ER expression provides a continuous recurrence risk assessment for patients being treated with tamoxifen, and therefore the standardization of the data across sites and imaging platforms significantly reduces the misclassification of patients when compared to the current standard by which ER expression is determined.Type: ApplicationFiled: December 2, 2011Publication date: December 26, 2013Applicants: UTI Limited Partnership, HistoRx, Inc.Inventors: Mark Gustavson, Jason Christiansen, Anthony Martin Magliocco
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Publication number: 20130310267Abstract: The present technology relates generally to determining a risk of recurrence of disease in a cancer patient. In particular, this approach to determining a risk of recurrence involves utilizing standardized quantitative assessments of the level of biomarker expression selected from estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 (Ki67) in a patient's tumor to determine the risk of recurrence, thereby allowing a caretaker to determine the best course of treatment for the patient.Type: ApplicationFiled: March 15, 2013Publication date: November 21, 2013Inventors: Mark D. GUSTAVSON, Jason CHRISTIANSEN
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Patent number: 8427635Abstract: Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.Type: GrantFiled: January 27, 2012Date of Patent: April 23, 2013Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Robert Pinard, Maciej P. Zerkowski, Gregory R. Tedeschi
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Patent number: 8314931Abstract: Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.Type: GrantFiled: August 12, 2011Date of Patent: November 20, 2012Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Robert Pinard, Maciej P. Zerkowski, Gregory R. Tedeschi
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Publication number: 20120133930Abstract: Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.Type: ApplicationFiled: January 27, 2012Publication date: May 31, 2012Inventors: Jason CHRISTIANSEN, Robert Pinard, Maciej P. Zerkowski, Gregory R. Tedeschi
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Patent number: 8120768Abstract: Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems.Type: GrantFiled: January 20, 2011Date of Patent: February 21, 2012Assignee: HistoRx, Inc.Inventors: Jason Christiansen, Robert Pinard, Maciej P. Zerkowski, Gregory R. Tedeschi