Abstract: Provided are intraoperative devices, the devices comprising a substrate having a plurality of discontinuous cuts formed therein, the plurality of discontinuous cuts being formed such that when the substrate is subjected to deformation, the substrate is capable of deformation beyond an initial state so as to achieve a first shaped three-dimensional state. Through design of the cut patterns in 2D, one can locally control the stretchability and elasticity within the substrate. The substrate can then be deformed into a 3D structure that can provide shape and support to reconstructed tissue in the desired regions while also minimizing operative time and cost. Also provided are related methods of using the disclosed devices; the devices can be used in autologous tissue donation procedures as well as prosthetic procedures.

Abstract: The invention concerns adhesives comprising a polymer network capable of conversion between two different elastic modulus states with essentially no residual stress evolved in conversion between the two different elastic modulus states, wherein the polymer network comprises either or both of (i) poly(2-hydroxy ethyl methacrylate) (PHEMA) hydrogel and/or a copolymers thereof, and (ii) a shape memory polymer. The invention also concerns methods of using such adhesives.

Abstract: Provided are intraoperative devices, the devices comprising a substrate having a plurality of discontinuous cuts formed therein, the plurality of discontinuous cuts being formed such that when the substrate is subjected to deformation, the substrate is capable of deformation beyond an initial state so as to achieve a first shaped three-dimensional state. Through design of the cut patterns in 2D, one can locally control the stretchability and elasticity within the substrate. The substrate can then be deformed into a 3D structure that can provide shape and support to reconstructed tissue in the desired regions while also minimizing operative time and cost. Also provided are related methods of using the disclosed devices; the devices can be used in autologous tissue donation procedures as well as prosthetic procedures.