Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.

Abstract: A well completion system comprises a tubing head which includes a central bore that extends axially therethrough and at least one fluid port that extends through the tubing head to the central bore, a tubing hanger which is supported in the central bore, an alignment pin which is mounted in the fluid port and which comprises a key portion that protrudes into the central bore, and structure for engaging the key portion to orient the tubing hanger relative to the tubing head. In this arrangement a blind flange may be secured to the tubing head over the fluid port to effectively seal the fluid port from the environment.