Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: Integrated table motion includes a computer-assisted device. The computer-assisted device includes articulating means; means for receiving, via a means for communicatively coupling the computer-assisted device with a table means, a table movement request from a table command means, the table means being separate from the computer-assisted device; means for determining whether the table movement request should be allowed; and means for allowing the table means to perform the table movement request based on determining that the table movement request should be allowed.

Abstract: Content is organized for brands by selecting a plurality of brand templates. After each selection, a set of properties is generated by applying a portion of settings of the respective brand template, with the remaining settings being overridden with settings for a channel communicating one of a plurality of presentations to a node of a network involved in the communication. The plurality of presentations may include different renditions of the same content. The properties may include sections configured for different focus areas and/or types of content associated with at tags to enable brand-level-targeting. Filters may be identified in the properties. Based on each of the identifications, a property from among the generated sets of properties may be selected based on comparisons with the associated tags.

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract: The disclosure provides a heat pump cycle that allows for an improved matching of the T(Q) slopes of the heat pump cycle. More particularly, the high temperature heat exchange is separated into two stages. Furthermore, a portion of the working fluid that was cooled in the first stage, is further cooled by expansion before being mixed with a heated working fluid for input to the recuperating heat exchanger.

Abstract: The disclosure provides a heat pump cycle that allows for an improved matching of the T(Q) slopes of the heat pump cycle. More particularly, the high temperature heat exchange is separated into two stages. Furthermore, a portion of the working fluid that was cooled in the first stage, is further cooled by expansion before being mixed with a heated working fluid for input to the recuperating heat exchanger.

Abstract: Systems and methods are provided for controlling the pressure of a working fluid at an inlet of a main pressurization device of a heat engine system. The heat engine system may include a control system and a working fluid circuit including a waste heat exchanger, an expansion device, a recuperator, a main pressurization device, and a heat exchanger assembly. The heat exchanger assembly may include a plurality of gas-cooled heat exchangers configured to transfer thermal energy from the working fluid to a cooling medium, a plurality of fans configured to direct the cooling medium into contact with the gas-cooled heat exchangers, and a plurality of drivers, each driver configured to drive a respective fan. The control system may be communicatively coupled to the heat exchanger assembly and configured to modulate a rotational speed of at least one fan to regulate a pressure of the working fluid at the inlet.

Abstract: Systems and methods are provided for controlling the pressure of a working fluid at an inlet of a main pressurization device of a heat engine system. The heat engine system may include a control system and a working fluid circuit including a waste heat exchanger, an expansion device, a recuperator, a main pressurization device, and a heat exchanger assembly. The heat exchanger assembly may include a plurality of gas-cooled heat exchangers configured to transfer thermal energy from the working fluid to a cooling medium, a plurality of fans configured to direct the cooling medium into contact with the gas-cooled heat exchangers, and a plurality of drivers, each driver configured to drive a respective fan. The control system may be communicatively coupled to the heat exchanger assembly and configured to modulate a rotational speed of at least one fan to regulate a pressure of the working fluid at the inlet.

Abstract: A heat engine system and a method for cooling a fluid stream in thermal communication with the heat engine system are provided. The heat engine system may include a working fluid circuit configured to flow a working fluid therethrough, and a cooling circuit in fluid communication with the working fluid circuit and configured to flow the working fluid therethrough. The cooling circuit may include an evaporator in fluid communication with the working fluid circuit and configured to be in fluid communication with the fluid stream. The evaporator may be further configured to receive a second portion of the working fluid from the working fluid circuit and to transfer thermal energy from the fluid stream to the second portion of the working fluid.

Abstract: A method for converting thermal energy into mechanical energy in a thermodynamic cycle includes placing a thermal energy source in thermal communication with a heat exchanger arranged in a working fluid circuit containing a working fluid (e.g., sc-CO2) and having a high pressure side and a low pressure side. The method also includes regulating an amount of working fluid within the working fluid circuit via a mass management system having a working fluid vessel, pumping the working fluid through the working fluid circuit, and expanding the working fluid to generate mechanical energy. The method further includes directing the working fluid away from the expander through the working fluid circuit, controlling a flow of the working fluid in a supercritical state from the high pressure side to the working fluid vessel, and controlling a flow of the working fluid from the working fluid vessel to the low pressure side.

Abstract: A heat engine system and a method for cooling a fluid stream in thermal communication with the heat engine system are provided. The heat engine system may include a working fluid circuit configured to flow a working fluid therethrough, and a cooling circuit in fluid communication with the working fluid circuit and configured to flow the working fluid therethrough. The cooling circuit may include an evaporator in fluid communication with the working fluid circuit and configured to be in fluid communication with the fluid stream. The evaporator may be further configured to receive a second portion of the working fluid from the working fluid circuit and to transfer thermal energy from the fluid stream to the second portion of the working fluid.

Abstract: Aspects of the disclosure generally provide a heat engine system and a method for regulating a pressure and an amount of a working fluid in a working fluid circuit during a thermodynamic cycle. A mass management system may be employed to regulate the working fluid circulating throughout the working fluid circuit. The mass management systems may have a mass control tank fluidly coupled to the working fluid circuit at one or more strategically-located tie-in points. A heat exchanger coil may be used in conjunction with the mass control tank to regulate the temperature of the fluid within the mass control tank, and thereby determine whether working fluid is either extracted from or injected into the working fluid circuit. Regulating the pressure and amount of working fluid in the working fluid circuit selectively increases or decreases the suction pressure of the pump to increase system efficiency.

Abstract: An automatic washing machine includes a wash additive dispenser for dispensing detergent and one or more additives into a wash tub. Water is delivered to a first wash agent chamber in the wash additive dispenser for delivery into a wash tub during a wash cycle. Water is subsequently delivered to a second wash agent chamber to flush from that chamber any unintended collection of water or additive residue therein, as may result from the water delivery to the first wash agent chamber and/or from an earlier dispensing of additive from the second wash agent chamber.

Abstract: An automatic washing machine includes a wash additive dispenser for dispensing detergent and one or more additives into a wash tub. Water is delivered to a first wash agent chamber in the wash additive dispenser for delivery into a wash tub during a wash cycle. Water is subsequently delivered to a second wash agent chamber to flush from that chamber any unintended collection of water or additive residue therein, as may result from the water delivery to the first wash agent chamber and/or from an earlier dispensing of additive from the second wash agent chamber.

Abstract: Embodiments provide a power generation device that utilizes a working fluid containing carbon dioxide within a working fluid circuit having high and low pressure sides. Components of the device may include a heat exchanger configured to be in thermal communication with a heat source whereby thermal energy is transferred from the heat source to the working fluid, an expander located between the high and low pressure sides of the working fluid circuit and operative to convert a pressure drop in the working fluid to mechanical energy, a recuperator operative to transfer thermal energy between the high and low pressure sides, a cooler operative to control temperature of the working fluid in the low pressure side, a pump operative to circulate the working fluid through the working fluid circuit, and a mass management system configured to control an amount of working fluid mass in the working fluid circuit.

Abstract: An automatic washing machine includes a wash additive dispenser for dispensing detergent and one or more additives into a wash tub. Water is delivered to a first wash agent chamber in the wash additive dispenser for delivery into a wash tub during a wash cycle. Water is subsequently delivered to a second wash agent chamber to flush from that chamber any unintended collection of water or additive residue therein, as may result from the water delivery to the first wash agent chamber and/or from an earlier dispensing of additive from the second wash agent chamber.

Abstract: Embodiments provide a heat engine system containing working fluid (e.g., sc-CO2) within high and low pressure sides of a working fluid circuit and a heat exchanger configured to transfer thermal energy from a heat source to the working fluid. The heat engine system further contains an expander for converting a pressure drop in the working fluid to mechanical energy, a shaft coupled to the expander and configured to drive a device (e.g., generator or pump) with the mechanical energy, a recuperator for transferring thermal energy between the high and low pressure sides, and a cooler for removing thermal energy from the working fluid in the low pressure side. The heat engine system also contains a pump for circulating the working fluid, a mass management system (MMS) fluidly connected to the working fluid circuit, and a supply tank fluidly connected to the MMS by a supply line.

Abstract: A method for converting thermal energy into mechanical energy in a thermodynamic cycle includes placing a thermal energy source in thermal communication with a heat exchanger arranged in a working fluid circuit containing a working fluid (e.g., sc-CO2) and having a high pressure side and a low pressure side. The method also includes regulating an amount of working fluid within the working fluid circuit via a mass management system having a working fluid vessel, pumping the working fluid through the working fluid circuit, and expanding the working fluid to generate mechanical energy. The method further includes directing the working fluid away from the expander through the working fluid circuit, controlling a flow of the working fluid in a supercritical state from the high pressure side to the working fluid vessel, and controlling a flow of the working fluid from the working fluid vessel to the low pressure side.

Abstract: A method for converting thermal energy into mechanical energy in a thermodynamic cycle includes placing a thermal energy source in thermal communication with a heat exchanger arranged in a working fluid circuit containing a working fluid (e.g., sc-CO2) and having a high pressure side and a low pressure side. The method also includes regulating an amount of working fluid within the working fluid circuit via a mass management system having a working fluid vessel, pumping the working fluid through the working fluid circuit, and expanding the working fluid to generate mechanical energy. The method further includes directing the working fluid away from the expander through the working fluid circuit, controlling a flow of the working fluid in a supercritical state from the high pressure side to the working fluid vessel, and controlling a flow of the working fluid from the working fluid vessel to the low pressure side.

Abstract: Aspects of the disclosure generally provide a heat engine system and a method for regulating a pressure and an amount of a working fluid in a working fluid circuit during a thermodynamic cycle. A mass management system may be employed to regulate the working fluid circulating throughout the working fluid circuit. The mass management systems may have a mass control tank fluidly coupled to the working fluid circuit at one or more strategically-located tie-in points. A heat exchanger coil may be used in conjunction with the mass control tank to regulate the temperature of the fluid within the mass control tank, and thereby determine whether working fluid is either extracted from or injected into the working fluid circuit. Regulating the pressure and amount of working fluid in the working fluid circuit selectively increases or decreases the suction pressure of the pump to increase system efficiency.