Abstract: A method of treating a patient suffering from vasopressor-induced digital ischemia of a hand, finger or thumb comprises providing Botulinum toxin; and injecting the Botulinum toxin in close proximity to one or more blood vessels that supply blood to the hand, finger or thumb, including and not limited to the palmar arch, ulnar and radial arteries. A method of treating a patient suffering from vasopressor-induced digital ischemia of the hand, finger(s), or thumb comprises providing Botulinum toxin; and injecting the Botulinum toxin in close proximity to one or more blood vessels that supply blood to the hand. A method of treating a patient suffering from vasopressor-induced digital ischemia of a foot comprises providing Botulinum toxin; and injecting the Botulinum toxin in close proximity to one or more blood vessels that supply blood to the toe(s) and foot, including and not limited to the plantar arch, anterior tibial/dorsalis pedis and posterior tibial arteries.

Abstract: Exemplary cutting and alignment guide assemblies for use in microsurgical, plastic surgical, otolaryngological, maxillofacial, orthopedic, dental, or other surgical procedures include a first section configured to engage a first bone graft section, a second section configured to engage a second bone graft section, a first fixation mechanism configured to couple the first section with the first bone graft section, and a second fixation mechanism configured to couple the second section with the second bone graft section. The first section and the second section can be coupled via a hinge mechanism. Neo-mandible assemblies for implantation at a native mandibular defect of a patient can include a cutting and alignment guide coupled with one or more bone graft sections. In some cases, bone graft sections include bone segments from a fibula of the patient.