Abstract: In one aspect, the disclosure relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide, and methods of use thereof. The disclosure further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants.

Abstract: Consolidation of disparate data source queries is provided. An application intake component can receive an application package file, and process the file to identify one or more actions and entities for the application. A natural language processor component can receive an input audio signal to identify an action and an entity on which to perform the action. An application delivery component can identify applications that can perform the action and applications that have access to the entity, and then select an application that is configured to perform the action on the entity. The application delivery component can provide an indication of the application selected by the system to a client device.

Abstract: Systems and methods of invoking functions of agents via digital assistant applications are provided. Each action-inventory can have an address template for an action by an agent. The address template can include a portion having an input variable used to execute the action. A data processing system can parse an input audio signal from a client device to identify a request and a parameter to be executed by the agent. The data processing system can select an action-inventory for the action corresponding to the request. The data processing system can generate, using the address template, an address. The address can include a substring having the parameter used to control execution of the action. The data processing system can direct an action data structure including the address to the agent to cause the agent to execute the action and to provide output for presentation.

Abstract: Disclosed in some examples are improvements to memory controllers on distributed memory systems that include a fine-grained data mover component that offloads management of memory commands accessing multiple smaller values to the memory controller. The fine-grained data mover (FGDM) may provide low host processing overhead that enables performance improvements for small task offloads. Work requests (“data mover calls”) may be sent by hosts to the FGDM without OS system calls. The FGDM is a virtually addressed data movement engine architected to transfer data at high transfer rates even during situations where the host has many small data movement requests and where the source and/or destination addresses are not memory controller friendly.

Abstract: Disclosed herein is an axle cartridge member for receiving a pair of torsion stub axles. The axle cartridge member includes a pair of laterally opposed bases, with each base defining a cavity therein for receiving an elongated stub housing of the torsion stub axles. The axle cartridge member also includes a pair of axle mounts that each includes a lateral opening extending into the cavity defined in the respective base, and an arch including a crossbar extending at a height above the bases wherein the arch further includes a portion that extends upward from each of the bases at an angle and meets the crossbar that extends generally horizontally between the portions of the arch.

Abstract: An axle cartridge member receives a pair of torsion stub axles at opposite lateral sides thereof. The torsion stub axles include elongated axle housings, which are sandwiched between two parallel plates to align the torsion stub axles with respect to one another. The cartridge member includes a central arch extending between the two torsion stub axles, which can provide additional ground clearance when the axle cartridge member is mounted to a trailer.

Abstract: A bale wrapping system that includes a belt that rotates to form and drive rotation of a bale of an agricultural product. The bale is configured to be wrapped with a wrapping layer of a bale wrap while rotating on the belt. A first portion of the wrapping layer overlaps a second portion of the wrapping layer while disposed on the belt. A glue system sprays a layer of glue onto the wrapping layer. The layer of glue enables the first portion of the wrapping layer to couple to the second portion of the wrapping layer.

Abstract: Systems and methods of invoking functions of agents via digital assistant applications are provided. Each action-inventory can have an address template for an action by an agent. The address template can include a portion having an input variable used to execute the action. A data processing system can parse an input audio signal from a client device to identify a request and a parameter to be executed by the agent. The data processing system can select an action-inventory for the action corresponding to the request. The data processing system can generate, using the address template, an address. The address can include a substring having the parameter used to control execution of the action. The data processing system can direct an action data structure including the address to the agent to cause the agent to execute the action and to provide output for presentation.

Abstract: Examples described herein relate to a method and a system for removing the common-mode current. The receiver includes a photodetector, a common-mode adjustment circuit, an analog front-end, an eye scan circuit, and a control unit. The photodetector generates an input photocurrent responsive to a received optical signal. The common-mode adjustment circuit generates an adjusted input current based on the input photocurrent. The analog front-end generates a differential voltage based on the adjusted input current. Based on the differential voltage, the eye scan circuit generates an eye scan information defining a first outer eye and a second outer eye in an eye diagram. The control unit tunes the common-mode adjustment circuit based on a relative height metric of a first height of the first outer eye and a second height of the second outer eye to remove a portion of the common-mode current from the input photocurrent.

Abstract: The present disclosure provides methods and diagnostic tools comprising classifiers and indicator cells that respond differentially to a sample derived from a subject having a disease or cancer, such as lung cancer, as compared to a control or normal sample. Also disclosed herein are methods of detecting a multicomponent gene expression readout from a genetically identical population of cells.

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.

Abstract: Systems and methods of invoking functions of agents via digital assistant applications are provided. Each action-inventory can have an address template for an action by an agent. The address template can include a portion having an input variable used to execute the action. A data processing system can parse an input audio signal from a client device to identify a request and a parameter to be executed by the agent. The data processing system can select an action-inventory for the action corresponding to the request. The data processing system can generate, using the address template, an address. The address can include a substring having the parameter used to control execution of the action. The data processing system can direct an action data structure including the address to the agent to cause the agent to execute the action and to provide output for presentation.

Abstract: Some embodiments include a system operable to construct hierarchical training data sets for use with machine-learning for multiple controlled devices. Other embodiments of related systems and methods are also provided.

Abstract: An axle cartridge member receives a pair of torsion stub axles at opposite lateral sides thereof. The torsion stub axles include elongated axle housings, which are sandwiched between two parallel plates to align the torsion stub axles with respect to one another. The cartridge member includes a central arch extending between the two torsion stub axles, which can provide additional ground clearance when the axle cartridge member is mounted to a trailer.

Abstract: The invention relates in particular to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined in the description and in the claims.

Abstract: Consolidation of disparate data source queries is provided. An application intake component can receive an application package file, and process the file to identify one or more actions and entities for the application. A natural language processor component can receive an input audio signal to identify an action and an entity on which to perform the action. An application delivery component can identify applications that can perform the action and applications that have access to the entity, and then select an application that is configured to perform the action on the entity. The application delivery component can provide an indication of the application selected by the system to a client device.

Abstract: Interruptible computing resources for executing queries may be selected. When queries are received, the probability that query can complete execution at interruptible computing resources may be determined. Computing resources to process the query may be selected based on the probability. For queries that are performed on computing resources that are interrupted, interruption handling techniques may retry the query on other computing resources or complete the query on other computing resources, in some embodiments.

Abstract: Examples described herein relate to a method and a system for removing the common-mode current. The receiver includes a photodetector, a common-mode adjustment circuit, an analog front-end, an eye scan circuit, and a control unit. The photodetector generates an input photocurrent responsive to a received optical signal. The common-mode adjustment circuit generates an adjusted input current based on the input photocurrent. The analog front-end generates a differential voltage based on the adjusted input current. Based on the differential voltage, the eye scan circuit generates an eye scan information defining a first outer eye and a second outer eye in an eye diagram. The control unit tunes the common-mode adjustment circuit based on a relative height metric of a first height of the first outer eye and a second height of the second outer eye to remove a portion of the common-mode current from the input photocurrent.

Abstract: A three dimensional printer can include: at least one beam configured to support a shuttle for a printhead of the three dimensional printer; and at least one tower configured to support the at least one beam; where the at least one beam and the at least one tower include a frame having a structural design produced from an iterative design process that employs a generative design algorithm to optimize a shape and/or topology of the frame, thereby reducing a ratio of a total mass over a total print build volume of the three dimensional printer.

Abstract: Consolidation of disparate data source queries is provided. An application intake component can receive an application package file, and process the file to identify one or more actions and entities for the application. A natural language processor component can receive an input audio signal to identify an action and an entity on which to perform the action. An application delivery component can identify applications that can perform the action and applications that have access to the entity, and then select an application that is configured to perform the action on the entity. The application delivery component can provide an indication of the application selected by the system to a client device.