Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: A hardware offload includes a hash engine that performs hashing for a block-based storage system. The hash engine calculates multiple hash values for each input buffer provided by the storage system. The hash values may be calculated with variably offset and overlapping portions of the input buffer, wherein each portion is larger than the native block size of the storage system. The hardware offload may also include a compression engine that performs compression on the input buffer using the entire input buffer and/or chunks as compression domains.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Embodiments of the present disclosure relate to an apparatus comprising a memory and at least one processor. The at least one processor is configured to: dynamically obtain a plurality of metadata from a global memory of a storage system; dynamically predict anticipated metadata based on the dynamically obtained metadata, wherein anticipated metadata is relevant to anticipated input/output (I/O) operations of the storage system; and dynamically instruct the storage system to load anticipated metadata into the global memory.

Abstract: Metadata in volatile memory is selectively compressed and destaged to non-volatile storage in the event of an emergency shutdown due to loss of like power. Compression offload hardware that is normally used for data compression is used to compress the metadata, e.g. at line speed. The compressed metadata and any uncompressed metadata that was not selected for compression may be destaged to vault drives along with compressed and uncompressed data that is in the volatile memory. Compression during vaulting may decrease power consumption when operating under standby battery power.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: Metadata in volatile memory is selectively compressed and destaged to non-volatile storage in the event of an emergency shutdown due to loss of like power. Compression offload hardware that is normally used for data compression is used to compress the metadata, e.g. at line speed. The compressed metadata and any uncompressed metadata that was not selected for compression may be destaged to vault drives along with compressed and uncompressed data that is in the volatile memory. Compression during vaulting may decrease power consumption when operating under standby battery power.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulate the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: A hardware offload includes a hash engine that performs hashing for a block-based storage system. The hash engine calculates multiple hash values for each input buffer provided by the storage system. The hash values may be calculated with variably offset and overlapping portions of the input buffer, wherein each portion is larger than the native block size of the storage system. The hardware offload may also include a compression engine that performs compression on the input buffer using the entire input buffer and/or chunks as compression domains.