Abstract: Data Integrity Field (DIF) is used to implement compression verification. When a write IO operation is received, the write IO operation is divided into data blocks, and a respective DIF is created and appended to each data block. When the write IO is compressed, the data blocks and respective DIF are collectively compressed to form compressed data. The compressed data is divided into compressed data blocks, and a respective second DIF is created and appended to each respective data block of compressed data. To verify that the compressed data is able to be decompressed, a copy of the compressed data is decompressed to restore the original data blocks and respective DIF. Each respective DIF is used to verify the content of its respective data block. In response to a determination that respective DIF match the respective data blocks, the decompression process is deemed to be verified.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: A hardware offload includes a hash engine that performs hashing for a block-based storage system. The hash engine calculates multiple hash values for each input buffer provided by the storage system. The hash values may be calculated with variably offset and overlapping portions of the input buffer, wherein each portion is larger than the native block size of the storage system. The hardware offload may also include a compression engine that performs compression on the input buffer using the entire input buffer and/or chunks as compression domains.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: Embodiments of the present disclosure relate to an apparatus comprising a memory and at least one processor. The at least one processor is configured to: dynamically obtain a plurality of metadata from a global memory of a storage system; dynamically predict anticipated metadata based on the dynamically obtained metadata, wherein anticipated metadata is relevant to anticipated input/output (I/O) operations of the storage system; and dynamically instruct the storage system to load anticipated metadata into the global memory.

Abstract: Metadata in volatile memory is selectively compressed and destaged to non-volatile storage in the event of an emergency shutdown due to loss of like power. Compression offload hardware that is normally used for data compression is used to compress the metadata, e.g. at line speed. The compressed metadata and any uncompressed metadata that was not selected for compression may be destaged to vault drives along with compressed and uncompressed data that is in the volatile memory. Compression during vaulting may decrease power consumption when operating under standby battery power.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: Metadata in volatile memory is selectively compressed and destaged to non-volatile storage in the event of an emergency shutdown due to loss of like power. Compression offload hardware that is normally used for data compression is used to compress the metadata, e.g. at line speed. The compressed metadata and any uncompressed metadata that was not selected for compression may be destaged to vault drives along with compressed and uncompressed data that is in the volatile memory. Compression during vaulting may decrease power consumption when operating under standby battery power.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: A storage system includes four storage engines, each storage engine including two compute nodes. Eight point-to-point connections are used to interconnect pairs of compute nodes on different storage engines, such that each compute node is connected to exactly two other compute nodes of the storage system. Atomic operations can be initiated by any compute node on any other compute node. Atomic operations received by a compute node on one of the point-to-point connections will be forwarded on the other point-to-point connection if the atomic operation is not directed to the compute node. During normal operation, atomic operations on a given compute node are performed on a host adapter associated with the compute node. Upon failure of the host adapter associated with the compute node, atomic operations may be performed on the compute node using the host adapter of the other compute node of the storage engine.

Abstract: A hardware offload includes a hash engine that performs hashing for a block-based storage system. The hash engine calculates multiple hash values for each input buffer provided by the storage system. The hash values may be calculated with variably offset and overlapping portions of the input buffer, wherein each portion is larger than the native block size of the storage system. The hardware offload may also include a compression engine that performs compression on the input buffer using the entire input buffer and/or chunks as compression domains.

Abstract: Embodiments of the present disclosure relate to an apparatus comprising a memory and at least one processor. The at least one processor is configured to: dynamically obtain a plurality of metadata from a global memory of a storage system; dynamically predict anticipated metadata based on the dynamically obtained metadata, wherein anticipated metadata is relevant to anticipated input/output (I/O) operations of the storage system; and dynamically instruct the storage system to load anticipated metadata into the global memory.

Abstract: A storage system includes a storage engine having a first compute node, a second compute node, a first fabric adapter, and a second fabric adapter, the first compute node having a first memory and the second compute node having a second memory. The first compute node is connected to both the first and second fabric adapters, and the second compute node is connected to both the second and first fabric adapters. Both fabric adapters are configured to perform atomic operations on a memory of its respective compute node, and each fabric adapter contains a multi-initiating module configured to enable both the first compute node and the second compute node to initiate memory access operations on its respective memory.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.