Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: Techniques for monitoring an online video advertisement system include receiving a request for insertion of an online video advertisement, determining, selectively based on presence of a debug suffix, whether the request includes a debug request, performing a bidding auction to select a winning bid, and sending debug information, in response to the request, upon determination that the request includes the debug request. The debug data includes bid data received during the bidding auction. In one advantageous aspect, the use of hypertext transfer protocol headers to communicate debug information allows for activation and deactivation of the debugging operation transparently, e.g., without changing the underlying application layer workflow.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: Techniques and systems for operating a video ad exchange includes controlling an ad server to receive ad requests from viewer devices, provide ad responses to viewer devices, generate an ad delivery data file that includes information about delivery of ads to the viewer devices, and transfer the ad delivery data file to a distributed computing cloud. The technique further includes controlling an ad data infrastructure mechanism to download the cloud-based ad delivery data file into a local memory, and process the copied ad delivery data file to generate billing data. An ad data infrastructure mechanism receives a configuration file from the ad server, verifies that all items in the configuration file from the ad server were used in the generation of the first billing data, and removes non-verifiable items from the first billing data to generate a final billing data.

Abstract: Techniques for monitoring an online video advertisement system include receiving a request for insertion of an online video advertisement, determining, selectively based on presence of a debug suffix, whether the request includes a debug request, performing a bidding auction to select a winning bid, and sending debug information, in response to the request, upon determination that the request includes the debug request. The debug data includes bid data received during the bidding auction. In one advantageous aspect, the use of hypertext transfer protocol headers to communicate debug information allows for activation and deactivation of the debugging operation transparently, e.g., without changing the underlying application layer workflow.

Abstract: A digital media advertisement delivery system comprising a real time bidding (RTB) platform and a plurality of bidder computers. The RTB platform is configured to receive an indication of an opportunity to display a digital media advertisement to a consumer, and generating a bid request for auctioning the opportunity to a plurality of bidders, the bid request comprising a plurality of fields including information about the opportunity. The plurality of bidder computers are configured to receive the bid request comprising a first plurality of fields including information about the opportunity, decide, based on the received information in the plurality of fields, whether or not to bid, and send a bid response, when decision is to bid, comprising a second plurality of response fields, at least some of which include information in direct response to the first plurality of fields.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: Techniques and systems for operating a video ad exchange includes controlling an ad server to receive ad requests from viewer devices, provide ad responses to viewer devices, generate an ad delivery data file that includes information about delivery of ads to the viewer devices, and transfer the ad delivery data file to a distributed computing cloud. The technique further includes controlling an ad data infrastructure mechanism to download the cloud-based ad delivery data file into a local memory, and process the copied ad delivery data file to generate billing data. An ad data infrastructure mechanism receives a configuration file from the ad server, verifies that all items in the configuration file from the ad server were used in the generation of the first billing data, and removes non-verifiable items from the first billing data to generate a final billing data.