Abstract: Sensor delivery devices and methods of measuring Fractional Flow Reserve in a patient are disclosed. One sensor delivery device includes a distal sleeve, a proximal portion, and a pressure sensor. The distal sleeve is configured to be advanced through a patient's vasculature over a guidewire. The pressure sensor is located on the distal sleeve or the proximal portion. The pressure sensor is adapted to generate a signal proportional to fluid pressure. The pressure sensor includes a material having a low thermal coefficient of pressure.

Abstract: Embodiments of the present invention allow more full characterization of a stenotic lesion by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. In preferred embodiments, the size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. In preferred embodiments, the intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries the pressure transducer(s).

Abstract: An intravascular imaging system can include a catheter, a position sensor, and an intravascular imaging engine for receiving information from the catheter and the position sensor. The position sensor can include a reference element and a movable element, which can have a movable element position that is correlated to the position of an imaging transducer in the catheter. The relative position between the movable element and a reference element can be determined and can correspond to the relative movement of the transducer within a patient's vasculature. The imaging engine can receive position information from the position sensor and image information from the catheter and generate a display using the received information. Because relative movement of the transducer can be determined, spatial relationships between sets of imaging data can be determined, and image data from multiple transducer locations can be combined into one image.

Abstract: Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.

Abstract: This disclosure provides systems and methods for intravascular imaging. Some systems may be configured to generate a screening image of a section of a patient's vessel, identify one or more sub-sections of the screening image that each include a diagnostically significant characteristic of the vessel, and imaging the one or more sub-sections. Some systems may be configured to automatically identify the one or more sub-sections and/or to allow a user to manually identify the one or more sub-sections. Some systems may be configured to automatically image the one or more sub-sections after the one or more sub-sections are identified. In some examples, the system may be configured to displace blood during imaging of the sub-sections to enhance image quality. The system may be configured to minimize the period of time blood is displaced by synchronizing imaging and blood displacement.

Abstract: Methods, systems, and devices are disclosed for administering one or more medications useful for facilitating diagnostic and/or surgical procedures within a patient. A guidewire is positioned intravascularly in a patient at a location of interest, the guidewire being free of any coating that includes adenosine. An intravascular component having a surface with a coating that includes a vasodilation agent is deployed over the guidewire. The vasodilation agent is released from the surface of the intravascular component, such as by eluting the vasodilation agent from the coating of the surface while the intravascular component is within the anatomical structure of the patient. The intravascular component is removed over the guidewire, and the guidewire is left at the location of interest after the intravascular component is removed, which can facilitate subsequent deployment of a different intravascular component over the guidewire.

Abstract: Sensor delivery devices and methods of measuring Fractional Flow Reserve in a patient are disclosed. One sensor delivery device includes a distal sleeve, a proximal portion, and a pressure sensor. The distal sleeve is configured to be advanced through a patient's vasculature over a guidewire. The pressure sensor is located on the distal sleeve or the proximal portion. The pressure sensor is adapted to generate a signal proportional to fluid pressure. The pressure sensor includes a material having a low thermal coefficient of pressure.

Abstract: Methods of measuring Fractional Flow Reserve (FFR) including advancing a sensor delivery device within a guiding catheter to a location of interest, the sensor delivery device comprising a distal sleeve including a distal sensor and a proximal sensor, advancing only a distal portion of the distal sleeve outside of the guiding catheter such that the distal sensor is outside of the guiding catheter and downstream of the location of interest and the proximal sensor is inside of the guiding catheter, measuring a distal fluid pressure with the distal sensor distal to the location of interest, measuring a reference fluid pressure with the proximal sensor inside of the guiding catheter, and calculating FFR. One or both of the proximal and distal sensor may be comprised of a material having a low thermal coefficient.

Abstract: An intravascular imaging system can include a catheter, a position sensor, and an intravascular imaging engine for receiving information from the catheter and the position sensor. The position sensor can include a reference element and a movable element, which can have a movable element position that is correlated to the position of an imaging transducer in the catheter. The relative position between the movable element and a reference element can be determined and can correspond to the relative movement of the transducer within a patient's vasculature. The imaging engine can receive position information from the position sensor and image information from the catheter and generate a display using the received information. Because relative movement of the transducer can be determined, spatial relationships between sets of imaging data can be determined, and image data from multiple transducer locations can be combined into one image.

Abstract: Methods, systems, and devices are disclosed for administering one or more medications useful for facilitating diagnostic and/or surgical procedures within a patient. A guidewire is positioned intravascularly in a patient at a location of interest, the guidewire being free of any coating that includes adenosine. An intravascular component having a surface with a coating that includes a vasodilation agent is deployed over the guidewire. The vasodilation agent is released from the surface of the intravascular component, such as by eluting the vasodilation agent from the coating of the surface while the intravascular component is within the anatomical structure of the patient. The intravascular component is removed over the guidewire, and the guidewire is left at the location of interest after the intravascular component is removed, which can facilitate subsequent deployment of a different intravascular component over the guidewire.

Abstract: An intravascular imaging system can include a catheter, a position sensor, and an intravascular imaging engine for receiving information from the catheter and the position sensor. The position sensor can include a reference element and a movable element, which can have a movable element position that is correlated to the position of an imaging transducer in the catheter. The relative position between the movable element and a reference element can be determined and can correspond to the relative movement of the transducer within a patient's vasculature. The imaging engine can receive position information from the position sensor and image information from the catheter and generate a display using the received information. Because relative movement of the transducer can be determined, spatial relationships between sets of imaging data can be determined, and image data from multiple transducer locations can be combined into one image.

Abstract: Embodiments of the present invention allow more full characterization of a stenotic lesion by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. In preferred embodiments, the size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. In preferred embodiments, the intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries the pressure transducer(s).

Abstract: A stenotic lesion can be characterized by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. The size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. Such one or more intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries a pressure transducer.

Abstract: Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.

Abstract: Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.

Abstract: This disclosure provides systems and methods for intravascular imaging. Some systems may be configured to generate a screening image of a section of a patient's vessel, identify one or more sub-sections of the screening image that each include a diagnostically significant characteristic of the vessel, and imaging the one or more sub-sections. Some systems may be configured to automatically identify the one or more sub-sections and/or to allow a user to manually identify the one or more sub-sections. Some systems may be configured to automatically image the one or more sub-sections after the one or more sub-sections are identified. In some examples, the system may be configured to displace blood during imaging of the sub-sections to enhance image quality. The system may be configured to minimize the period of time blood is displaced by synchronizing imaging and blood displacement.

Abstract: Methods of measuring Fractional Flow Reserve (FFR) including advancing a sensor delivery device within a guiding catheter to a location of interest, the sensor delivery device comprising a distal sleeve including a distal sensor and a proximal sensor, advancing only a distal portion of the distal sleeve outside of the guiding catheter such that the distal sensor is outside of the guiding catheter and downstream of the location of interest and the proximal sensor is inside of the guiding catheter, measuring a distal fluid pressure with the distal sensor distal to the location of interest, measuring a reference fluid pressure with the proximal sensor inside of the guiding catheter, and calculating FFR. One or both of the proximal and distal sensor may be comprised of a material having a low thermal coefficient.

Abstract: An intravascular imaging system can include a catheter, a position sensor, and an intravascular imaging engine for receiving information from the catheter and the position sensor. The position sensor can include a reference element and a movable element, which can have a movable element position that is correlated to the position of an imaging transducer in the catheter. The relative position between the movable element and a reference element can be determined and can correspond to the relative movement of the transducer within a patient's vasculature. The imaging engine can receive position information from the position sensor and image information from the catheter and generate a display using the received information. Because relative movement of the transducer can be determined, spatial relationships between sets of imaging data can be determined, and image data from multiple transducer locations can be combined into one image.

Abstract: Methods and sensor delivery devices for monitoring a fluid pressure within a vascular structure, the devices including an elongated sheath sized for sliding along a guidewire, a sensor assembly including a fiber optic sensor, a housing surrounding the sensor, a first cavity between the distal end of the sensor and a distal aperture of the housing, a filler extending from at least the distal end of the housing distally and tapering inward toward the outer surface of the sheath, a second cavity in the filler with an opening at the outer surface of the filler and adjoining the distal aperture of the housing, and an optical fiber. The sensor delivery device may also include an outer layer that partially covers the second cavity with an aperture over the opening of the second cavity.

Abstract: Embodiments of the present invention allow more full characterization of a stenotic lesion by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. In preferred embodiments, the size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. In preferred embodiments, the intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries the pressure transducer(s).