Abstract: Recent literature on SARS-CoV-2 pathogenesis has suggested that the induction of substantial acute respiratory distress phenotypes is driven by a mismatched inflammatory response together with broad vascular dysfunction. While several detailed reports implementing multi-omic approaches have provided insight into the immune cell phenotypes involved in these processes, risk stratifying markers specific to COVID-19 and the vasculature have not been explored. Provided herein is a comprehensive, multi-omics-based description of the molecular antecedents to COVID-19 mortality, yielding new insights pertaining to the vasculature while highlighting the urgent need for clinical translation of novel biomarkers for disease prognosis.

Abstract: A gas turbine engine includes a fan assembly, a compressor assembly, a combustion chamber, a turbine assembly, a bypass duct conveying rearward a bypass airstream driven by the fan assembly when the gas turbine engine is in use, a fairing extending across at least a portion of the bypass duct downstream of the fan assembly, and a heat exchanger having an inlet fluidly connected to the compressor assembly and an outlet fluidly connected to a pneumatic actuator of the gas turbine engine. The fairing has a leading edge and a trailing edge. The heat exchanger is disposed adjacent the trailing edge of the fairing.

Abstract: The heat exchanger can have a first fluid circuit extending from a first inlet to a first outlet, one or both having a first mouth dividing internally into a number of passages within a periphery, a second fluid circuit fluidly distinct from the first fluid circuit, extending from a second inlet to a second outlet, the second fluid circuit in thermal exchange contact with the number of passages in a heat transfer region of the heat exchanger, and an adapter having a second mouth secured to the first mouth in a manner to establish internal fluid flow communication therewith.

Abstract: A turbofan engine comprising an outer bypass duct, an annular bypass flow path between the outer bypass duct and a core engine, an engine component forming an airflow obstruction adjacent the outer bypass duct, an air cooler having a tube, the tube having at least a sinuous portion extending in the annular bypass flow path, the sinuous portion extending along the outer bypass duct, downstream of the airflow obstruction, the sinuous portion configured for exchanging heat between a fluid circulating in the tube and air circulating in the bypass flow path during operation of the turbofan engine.

Abstract: A turbofan engine comprising an outer bypass duct, an annular bypass flow path between the outer bypass duct and a core engine, an engine component forming an airflow obstruction adjacent the outer bypass duct, an air cooler having a tube, the tube having at least a sinuous portion extending in the annular bypass flow path, the sinuous portion extending along the outer bypass duct, downstream of the airflow obstruction, the sinuous portion configured for exchanging heat between a fluid circulating in the tube and air circulating in the bypass flow path during operation of the turbofan engine.

Abstract: A gas turbine engine includes a fan assembly, a compressor assembly, a combustion chamber, a turbine assembly, a bypass duct conveying rearward a bypass airstream driven by the fan assembly when the gas turbine engine is in use, a fairing extending across at least a portion of the bypass duct downstream of the fan assembly, and a heat exchanger having an inlet fluidly connected to the compressor assembly and an outlet fluidly connected to a pneumatic actuator of the gas turbine engine. The fairing has a leading edge and a trailing edge. The heat exchanger is disposed adjacent the trailing edge of the fairing.

Abstract: A mounting method and system for supporting and positioning an internal fuel manifold relative to a combustor in a fuel injection system for a gas turbine engine. The method includes positioning the fuel manifold within a gas generator casing, applying a heat shield around a radially extending fuel inlet connected to the fuel manifold, and using the heat shield to at least partially support the fuel manifold within the gas generator casing.

Abstract: A fuel manifold assembly for a gas turbine engine fuel system comprises a fuel manifold at least partly enclosed by a heat shield, the internal manifold being made of a first material having a first coefficient of thermal expansion, and the heat shield being made of a second material having a second coefficient of thermal expansion that is lower than the first coefficient of thermal expansion.

Abstract: An access conduit for access to the interior of a combustor for the washing of the turbine components of a gas turbine engine. The access conduit is secured between a gas generator case and a combustion chamber liner of the combustor. The access conduit has an open outer end accessible from an outer face of the gas generator case and an open inner end exiting in a combustion chamber through the liner. The access conduit has one or more openings disposed in a combustor gap between the gas generator case and the liner of the combustor. A plug is removably secured in the open outer end and extends into the access conduit to obstruct the one or more openings.

Abstract: A fuel conveying member of a gas turbine engine is described and includes a fuel manifold defining an annular fuel flow passage through a body of the fuel manifold. A plurality of fuel nozzles extend from the manifold in fluid flow communication with the annular fuel flow passage. The fuel manifold includes integral attachment lugs thereon for mounting the fuel manifold within the gas turbine engine. The attachment lugs are adapted to receive pins therein and provide a mounting mechanism which allows for thermal expansion of the fuel manifold relative to a surrounding support structure to which the fuel manifold is mounted via the attachment lugs.

Abstract: A mounting method and system for supporting and positioning an internal fuel manifold relative to a combustor in a fuel injection system for a gas turbine engine. The method includes positioning the fuel manifold within a gas generator casing, applying a heat shield around a radially extending fuel inlet connected to the fuel manifold, and using the heat shield to at least partially support the fuel manifold within the gas generator casing.

Abstract: A mounting system supporting and positioning an internal fuel manifold of a gas turbine engine includes at least a heat shield surrounding a fuel inlet of the fuel manifold, the heat shield bearing at least a portion of a load to support the fuel manifold.

Abstract: A system for mounting an internal fuel manifold within a gas generator case of a gas turbine engine includes at least one fastener support assembly having a fastener pin and at least one receiving element, respectively engaged to either the internal fuel manifold or the gas generator case. A biasing member is located between the fastener pin and the receiving element to axially preload the joint between the fastener pin and the receiving element, such as to constrain relative movement between the two parts in an axial direction while allowing relative movement in a radial direction.

Abstract: A fuel conveying member for a gas turbine engine, the fuel conveying member including a fuel manifold having a plurality of fuel nozzles extending therefrom. The fuel manifold is mounted within the engine by a support system, including integral attachment lugs on the fuel manifold for mounting the fuel manifold within the gas turbine engine. The attachment lugs re adapted to receive pins therein and provide a mounting mechanism which allows for thermal expansion of the fuel manifold relative to a surrounding support structure to which the fuel manifold is mounted via the attachment lugs.

Abstract: A fuel conveying member of a gas turbine engine is described and includes a fuel manifold defining an annular fuel flow passage through a body of the fuel manifold. A plurality of fuel nozzles extend from the manifold in fluid flow communication with the annular fuel flow passage. The fuel manifold includes integral attachment lugs thereon for mounting the fuel manifold within the gas turbine engine. The attachment lugs are adapted to receive pins therein and provide a mounting mechanism which allows for thermal expansion of the fuel manifold relative to a surrounding support structure to which the fuel manifold is mounted via the attachment lugs.

Abstract: A gas turbine engine fuel nozzle system having a fuel conveying member with a channel formed in a surface thereof defined between a pair of facing spaced apart walls, and at least one sealing member disposed within the channel and sealingly fastened to the spaced apart walls.

Abstract: A fuel conveying member for an engine, the fuel conveying member having heating means integrated therein to permit pyrolysis of carbonaceous deposits.

Abstract: A mounting system for an annular internal fuel manifold disposed within a gas generator case of a gas turbine engine including at least one fastener support assembly and at least one receiving element, each fastener support assembly including a primary fastener engaging the receiving element to constrain a relative movement between the fuel manifold and the gas generator case in an axial direction while allowing the relative movement in a radial direction and a secondary fastener in position to passively and automatically engage the receiving element upon failure of the primary fastener.

Abstract: A heat shield for a fuel member of a gas turbine engine having at least one heat shield segment having a connection edge with at least one joint receiving portion defined therealong for receiving a welded joint attaching the heat shield segment to a fuel member, each joint receiving portion including a stress relieving feature defined along at least one end thereof.

Abstract: A fuel manifold assembly for a gas turbine engine includes an annular fuel manifold having at least one fuel conveying passage and defining at least one slow fuel flowing location. A heat shield at least partly encloses the fuel manifold and a plurality of intermittent joints attach the heat shield to the fuel manifold. The joints are circumferentially distributed about the fuel manifold as far away from the slow flowing location as possible while maintaining the fuel manifold dynamically balanced.