Abstract: A disconnect sub is connected at one end to a pipe for deployment into a well, where the disconnect sub is then connected to a downhole sealing device such as a plug. The disconnect sub comprises a disconnection point that has a lower tensile break value than the rest of the plug, and has a predetermined tensile break value such that the disconnection point will fail when a threshold value of axial tensile load is applied to the disconnect sub. This offers two methods of disconnection of the pipe from the plug after the plug has set—firstly, rotation of the pipe, or if rotation is not possible, overpull of the pipe in excess of the threshold will cause failure of the disconnection point and separation of the pipe from the plug.

Abstract: A disconnect sub is connected at one end to a pipe for deployment into a well, where the disconnect sub is then connected to a downhole sealing device such as a plug. The disconnect sub comprises a disconnection point that has a lower tensile break value than the rest of the plug, and has a predetermined tensile break value such that the disconnection point will fail when a threshold value of axial tensile load is applied to the disconnect sub. This offers two methods of disconnection of the pipe from the plug after the plug has set—firstly, rotation of the pipe, or if rotation is not possible, overpull of the pipe in excess of the threshold will cause failure of the disconnection point and separation of the pipe from the plug.

Abstract: A squeeze packer (1) assembly incorporates a built-in setting tool which removes the need for a separate setting tool. The packer comprises a body comprising a mandrel (9), a shuttle sleeve (7), and a stinger (2) assembly which is lowered into the wellbore on the end of tubing (102). The shuttle sleeve is housed within the body and incorporates a latch device in the form of a collet comprising a plurality of resilient fingers (14) to releasably connect to the stinger. A ball seat (15) allows hydraulic setting of slips (3). Additional slips (4) can be set by applying tension on the tubing (FIG. 4). Once released, the stinger can open and close the shuttle sleeve by reciprocating in and out of the packer as many times as required during cementing operations.

Abstract: A squeeze packer (1) assembly incorporates a built-in setting tool which removes the need for a separate setting tool. The packer comprises a body comprising a mandrel (9), a shuttle sleeve (7), and a stinger (2) assembly which is lowered into the wellbore on the end of tubing (102). The shuttle sleeve is housed within the body and incorporates a latch device in the form of a collet comprising a plurality of resilient fmgers (14) to releasably connect to the stinger. A ball seat (15) allows hydraulic setting of slips (3). Additional slips (4) can be set by applying tension on the tubing (FIG. 4). Once released, the stinger can open and close the shuttle sleeve by reciprocating in and out of the packer as many times as required during cementing operations.

Abstract: A downhole support device for use in a wellbore is provided, where the device (200) is adapted to be run into the wellbore (202) through or on a workstring (204). The device (200) comprises an inflatable element (206) adapted to be selectively connectable to the workstring (204). The inflatable element (206) selectively applies a biasing force to an external structure such, for example, a wall (214) of the wellbore (202) when in an inflated state. The inflatable element (206) has an inlet (208) for receiving and being inflated by a flowing substance. The device (200) also comprises an inflation mechanism (210) and a disconnect mechanism (222) adapted to be selectively disconnectable from the workstring (204). A method of deploying a barrier in a wellbore which makes use of the support device is also provided.

Abstract: A deformable cleaning element is encased within soluble packaging to maintain deformation. The deformed cleaning element is launched into the bore of a drill pipe/conduit or tubular. Contact with fluids within the bore dissolves the soluble packaging allowing the cleaning element to expand to its original shape.

Abstract: A deformable cleaning element is encased within soluble packaging to maintain deformation. The deformed cleaning element is launched into the bore of a drill pipe/conduit or tubular. Contact with fluids within the bore dissolves the soluble packaging allowing the cleaning element to expand to its original shape.

Abstract: A device and method of use thereof enable a portable device to be moveably disposed between a smoker and an output access point of a smoking pipe. The device temporarily forms a channel for inhalants to pass from a smoking pipe to a user's mouth. The smoking pipe may be selected from at least two different pipe structures. A cross section of the channel may be circular, orthogonal or elliptical. The device may include a particulate filter positioned between an inhalant input location and inhalant output location of the device. The filter may be insertable and removable from the tube. A source ledge may extend outward from the inhalant input location and/or a mouth end ledge may extend beyond a cross-section of the channel. A plurality of removable mouthpieces may be alternatively coupled and removed from the inhalant output location. The mouthpiece or a source piece may be elastic.

Abstract: A deformable cleaning element is encased within soluble packaging to maintain deformation. The deformed cleaning element is launched into the bore of a drill pipe/conduit or tubular. Contact with fluids within the bore dissolves the soluble packaging allowing the cleaning element to expand to its original shape.

Abstract: A downhole support device for use in a wellbore is provided, where the device (200) is adapted to be run into the wellbore (202) through or on a workstring (204). The device (200) comprises an inflatable element (206) adapted to be selectively connectable to the workstring (204). The inflatable element (206) selectively applies a biasing force to an external structure such, for example, a wall (214) of the wellbore (202) when in an inflated state. The inflatable element (206) has an inlet (208) for receiving and being inflated by a flowing substance. The device (200) also comprises an inflation mechanism (210) and a disconnect mechanism (222) adapted to be selectively disconnectable from the workstring (204). A method of deploying a barrier in a wellbore which makes use of the support device is also provided.

Abstract: The invention features methods and compositions for the treatment of immunonflammatory disorders.

Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.

Abstract: The invention features methods and compositions for the treatment of immunoinflammatory disorders.

Abstract: A system for optimizing on-premises advertising, for example, at retail food and/or beverage establishments, such as bars, restaurants, night clubs, sports stadiums and other on-premise retail sites. The optimization is based upon on-premise sales data which includes point-of-sale (POS) data and may also take into account waste, spoilage, theft etc (“collectively “native sales data”). In one embodiment of the invention, the system is able to optimize which products are advertised based upon native sales data. In other embodiments of the invention, the system is able to determine the effectiveness of impulse advertisements for the selected products as well as the timing of the impulse advertisements in order to increase sales of selected products and increase the profitability of the retail establishment and improve the return on impulse ad costs.

Abstract: The invention features methods and compositions for the treatment of immunonflammatory disorders.

Abstract: The invention features a method for treating a patient diagnosed with rheumatoid arthritis by systemically administering an azole and a steroid to the patient. The invention also features a pharmaceutical composition containing an azole and a steroid for the treatment of rheumatoid arthritis.

Abstract: The invention features a method for treating a patient diagnosed with rheumatoid arthitis by systemically administering an azole and a steroid to the patient. The invention also features a pharmaceutical composition containing an azole and a steroid for the treatment of rheumatoid arthritis.

Abstract: The invention features methods and compositions for the treatment of inflammatory skin conditions.

Abstract: The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.

Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.