Abstract: Provided herein are delivery particle systems (XDP) useful for the delivery of payloads of any type. In some embodiments, a XDP particle system with tropism for target cells of interest is used to deliver CRISPR/Cas polypeptides (e.g., CasX proteins) and guide nucleic acids (gNA), for the modification of nucleic acids in target cells. Also provided are methods of making and using such XDP to modify the nucleic acids in such cells.

Abstract: Various implementations of an illumination system include a light guide, a housing having a ceiling and defining a window, and a base coupled to the housing. The light guide is supported between the base and the ceiling. At least one light source is disposed adjacent a first end of the light guide. The light guide transmits the light from the light source through at least a portion of the outer surface of the light guide and the window. One or more tabs extending from the base each define at least one opening, and the at least one opening defined by each tab is alignable with an opening in a spoke portion of a frame. The openings receive a fastener to couple the base to the spoke portion. The housing may be integrally formed with a trim cover coupled to the frame.

Abstract: A system and method for lighting a surface, for example a deck of a boat, spa, swim spa, pool, watercraft or vehicle, using backlighting such that decorative or other desired patterns of light may be created by forming cuts, outlines, thin sections, or voids in an overlay that is applied to the lighted surface, allowing light to pass through or around portions of the overlay material. In an exemplary use of the system and method of the invention, the surface may be the surface of a boat or spa. The surface may comprise transparent or translucent materials, allowing light from a first side of the decking, or light that is generated within the decking, to pass through the decking and to emanate from a second decking side, where the light may be blocked, partially blocked, or allowed to pass through the overlay material in any desired pattern or shape.

Abstract: A lighting system includes a base structure comprising a transparent or translucent material, a surface covering including a first surface layer, a second surface layer having a first surface facing a second surface of the first surface layer and a second surface facing a first surface of the base structure, and at least one light source disposed to as to illuminate at least a portion of the base structure with light energy such that at least a portion of the light energy passes through the at least a portion of the base structure and into the surface covering, and wherein the surface covering includes a void extending at least partially between the first surface of the first surface layer and the second surface of the second surface layer and configured to allow at least some of the light energy passing through the base structure to pass through the void.

Abstract: A system and method for lighting a surface, for example a deck of a boat, spa, swim spa, pool, watercraft or vehicle, using backlighting such that decorative or other desired patterns of light may be created by forming cuts, outlines, thin sections, or voids in an overlay that is applied to the lighted surface, allowing light to pass through or around portions of the overlay material. In an exemplary use of the system and method of the invention, the surface may be the surface of a boat or spa. The surface may comprise transparent or translucent materials, allowing light from a first side of the decking, or light that is generated within the decking, to pass through the decking and to emanate from a second decking side, where the light may be blocked, partially blocked, or allowed to pass through the overlay material in any desired pattern or shape.

Abstract: A shopping cart basket comprises one or more modular baskets couplable to a bottom basket having a plurality of wheels extending downwardly to allow the shopping cart basket to roll. Each of the modular baskets has a foldable bottom wall that can act as a bottom of a separate basket or can be folded against a side wall of the modular basket. The modular baskets could be used to hold items within a smaller compartment, and can be combined with the bottom basket to form a roll-able shopping cart having a larger compartment. Such a cart is advantageously used in a store, such as a grocery store, a retail shopping mall, or a home improvement store.

Abstract: A shopping cart basket comprises one or more modular baskets couplable to a bottom basket having a plurality of wheels extending downwardly to allow the shopping cart basket to roll. Each of the modular baskets has a foldable bottom wall that can act as a bottom of a separate basket or can be folded against a side wall of the modular basket. The modular baskets could be used to hold items within a smaller compartment, and can be combined with the bottom basket to form a roll-able shopping cart having a larger compartment. Such a cart is advantageously used in a store, such as a grocery store, a retail shopping mall, or a home improvement store.

Abstract: A track pad assembly for a continuous track vehicle includes a track plate and a polymer pad. The track plate includes a plate body having a tread surface, and one or more mesh arrays attached to the tread surface of the plate body. The polymer pad is attached to the mesh array(s) and to interstitial areas of the tread surface defined by cells of the mesh array(s), e.g., by press bonding in conjunction with an adhesive. The polymer pad may be made of an elastomer such as hardened rubber.

Abstract: A system and method for lighting a surface, for example a deck of a boat, spa, swim spa, pool, watercraft or vehicle, using backlighting such that decorative or other desired patterns of light may be created by forming cuts, outlines, thin sections, or voids in an overlay that is applied to the lighted surface, allowing light to pass through or around portions of the overlay material. In an exemplary use of the system and method of the invention, the surface may be the surface of a boat or spa. The surface may comprise transparent or translucent materials, allowing light from a first side of the decking, or light that is generated within the decking, to pass through the decking and to emanate from a second decking side, where the light may be blocked, partially blocked, or allowed to pass through the overlay material in any desired pattern or shape.

Abstract: Various techniques are provided to perform flat field correction (FFC) for infrared cameras. In one example, a system includes a focal plane array (FPA) of an infrared camera configured to capture thermal image data in response to infrared radiation received by the FPA via an optical path of the infrared camera. The system further includes a memory configured to store a set of supplemental FFC values. The system further includes a processor configured to determine a scale factor based at least on a temperature and/or a rate of temperature change of an internal component of the infrared camera; generate a scaled set of supplemental FFC values based on the scale factor and set of supplemental FFC values; and apply the scaled set of supplemental FFC values to the thermal image data to adjust for non-uniformities associated with at least a portion of the first optical path.

Abstract: A shopping cart basket comprises one or more modular baskets couplable to a bottom basket having a plurality of wheels extending downwardly to allow the shopping cart basket to roll. Each of the modular baskets has a foldable bottom wall that can act as a bottom of a separate basket or can be folded against a side wall of the modular basket. The modular baskets could be used to hold items within a smaller compartment, and can be combined with the bottom basket to form a roll-able shopping cart having a larger compartment. Such a cart is advantageously used in a store, such as a grocery store, a retail shopping mall, or a home improvement store.

Abstract: A connectorized lighting system for a base structure such as a deck pad, comprising a base structure having an a retaining cavity disposed in and running along a surface of the base structure, a lighting element inserted into the retaining cavity, and connectorized light source that provides electrical power to the lighting element, exhibits a low profile, and may be removable and replaceable without tools. The base structure may be a deck pad on a boat or a covering for a floor, spa, spa cabinet, pool, or any other surface. The deck may comprise EVA or PE foam material, and may comprise one or more layers of sheet material. The retaining cavity may comprise a window and bevels for visibility. A lighting element may be held in place by forces created when the compressible material of the base structure is compressed by pressing the lighting element into the retaining cavity.

Abstract: Various techniques are provided to perform flat field correction (FFC) for infrared cameras. In one example, a system includes a focal plane array (FPA) of an infrared camera configured to capture thermal image data in response to infrared radiation received by the FPA via an optical path of the infrared camera. The system further includes a memory configured to store a set of supplemental FFC values. The system further includes a processor configured to determine a scale factor based at least on a temperature and/or a rate of temperature change of an internal component of the infrared camera; generate a scaled set of supplemental FFC values based on the scale factor and set of supplemental FFC values; and apply the scaled set of supplemental FFC values to the thermal image data to adjust for non-uniformities associated with at least a portion of the first optical path.

Abstract: A surface covering, which may be a non-skid covering such as a traction pad for use on a surface of a boat, kayak, watercraft, recreational vehicle, golf cart, pool deck, spa surface, swim spa surface, floor or wall surface, spa cabinet or other structure which has glow in the dark or photo-luminescent properties. The surface covering material may comprise one or more layers of material attached to each other. The surface covering material may comprise EVA foam, which may be routed. Photo-luminescent materials are applied to any surface of the surface covering. The photo-luminescent material may be mixed with a bonding agent prior to being applied to the surface covering. In an embodiment, photo-luminescent are applied to a route in the surface covering. The photo-luminescent materials may comprise a rare earth metal. The invention comprises a method for manufacturing the photo-luminescent surface covering.

Abstract: A structure for retaining an object such as a lighting element, comprising a base structure having at least one surface and a retaining cavity disposed in a surface of the base structure, wherein the retaining cavity cross section comprises opposing tapered window retention surfaces and opposing bevel surfaces disposed between the surface opening and each of the opposing tapered window retention surfaces. A lighting element may be disposed in the retaining cavity. The retaining cavity may have a cross section that is complementary to a cross section of an object to be retained. A lighting system for a base structure comprising a plurality of stacked planar sheets, having a lighting element disposed between a top sheet and the next planar sheet below the top sheet in the stack of sheets, oriented such that a portion of the light emitted by the lighting element passes through said top sheet.

Abstract: The present disclosure relates to a power isolation adapter which can enable the use of multiple power sources in a bottom hole assembly (BHA) by isolating the power sources on a tool bus while maintaining a communication bus across the BHA. Such power sources may be part of a measurement-while-drilling (MWD) module, such as a mud turbine generator, providing power as a DC signal. The power isolation adapter isolates the power sources by blocking DC signals, but maintains an AC communication bus across the BHA. The ability to use multiple power sources in a BHA thus allows for more complex BHA configurations that normally could not be powered using a single power source.

Abstract: The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

Abstract: A technique includes receiving sensor data; sorting the data into a gather representation that corresponds to a plurality of shots of an energy source; and determining a signal cone based at least in part on at least one characteristic of the gather representation. The technique includes processing the sensor data in a processor-based machine to attenuate noise to generate data representing a signal based at least in part on the determined signal cone and the gather representation.

Abstract: A system and method for supplying uninterruptible power include a housing, a power supply input, a power source equipment input, a powered device output, an alternative power supply, and a control module. The control module includes a comparator, a switch, and an injector. A PoE powered device connects to the powered device output by Ethernet cable, and power source equipment connects to the power source equipment input. The control module connects the power supply input, the power source equipment input, the powered device output, and the alternative power supply. The power source equipment is powered separate from the power supply input. When the comparator detects sufficient power from the power supply unit, the switch directs power from the power supply input to the powered device. When the comparator detects insufficient power from the power supply unit, the switch instantaneously directs power from the alternative power supply to the powered device.

Abstract: The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.