Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Disclosed are a method, system and apparatus for use in a network of devices which can facilitate the installation of the network. In a network consisting of multiple devices, it is often necessary to use repeaters to relay communications between two or more devices that are out of range of each other. The various aspects of the present invention provide for one or more of the devices to be selectively switched to operate as a repeater.

Abstract: A vehicle for separating a mixed debris stream is disclosed. The vehicle includes an elongate vehicle frame; a separating assembly configured to contact the mixed debris stream with a fluid stream to separate the mixed debris stream into at least a first debris stream and a second debris stream, and at least one of the first debris stream and the second debris stream includes fluid from the fluid stream; a first conveyor; a second conveyor; and a fluid collection structure configured to receive fluid from at least the separating assembly and the second conveyor, wherein the first conveyor is configured to drain at least some fluid from the first debris stream, to the second conveyor, and the second conveyor includes a non-mesh conveyor belt configured to drain at least some fluid from at least one of the first debris stream and the second debris stream to the fluid collection structure.

Abstract: A vehicle for breaking material is disclosed. The vehicle includes: an elongate vehicle frame; a feeder having a feed end portion and a discharge end portion, wherein the feeder is configured to convey the material from the feed end portion to the discharge end portion; and a material breaker supported via the vehicle frame with a feed end portion that is downstream from the discharge end portion of the feeder. The material breaker includes: a platform configured to support the material received from the feeder, at least one breaker element configured to move towards the platform and contact at least a portion of the material received from the feeder and supported by the platform, wherein movement of the at least one breaker element towards the platform is assisted, at least in part, by gravitational forces, and a lifting mechanism configured to move the at least one breaker element away from the platform.

Abstract: A system for conveying material is disclosed. The system includes: a hopper having a feed end and a discharge end, wherein the feed end is configured to receive material; and an elongate conveyor downstream from the discharge end, wherein the elongate conveyor is configured to pivot about at least three axes.

Abstract: A vehicle for conveying material is disclosed. The vehicle includes: an elongate vehicle frame; a hopper with a feed end and a discharge end, wherein the feed end is configured to receive the material; and an elongate material conveyor supported via the vehicle frame with a feed end downstream from the discharge end of the hopper and extending from its feed end to a discharge end. A substantial portion of the elongate material conveyor is configured to pivot about at least three axes, and the elongate material conveyor is adjustable among an inoperative position and plural extended positions.

Abstract: Feeder systems are mechanical systems that feed individual sheets of paper to other mechanical devices. Feeder systems need to be able to handle a variety of types of paper with different weights and finishes. Glossy paper has proven difficult to feed because of anti-offset agents used in the printing process. The agents contaminate the rollers in the feeder system causing misfeeds and jams. The present invention is a cleaning apparatus that can be used in conjunction with the feeder system to keep the feeder system free from malfunctions during the processing of glossy paper. The cleaning apparatus includes a cleaning head mounted on a supporting arm. Various types of abrasive cleaning heads can be employed in the cleaning apparatus such as metal blades, meshes and brushes. The cleaning heads keep the rollers operational while minimizing deterioration of the roller.

Abstract: Feeder systems are mechanical systems that feed individual sheets of paper to other mechanical devices. Feeder systems need to be able to handle a variety of types of paper with different weights and finishes. Glossy paper has proven difficult to feed because of anti-offset agents used in the printing process. The agents contaminate the rollers in the feeder system causing misfeeds and jams. The present invention is a cleaning apparatus that can be used in conjunction with the feeder system to keep the feeder system free from malfunctions during the processing of glossy paper. The cleaning apparatus includes a cleaning head mounted on a supporting arm. Various types of abrasive cleaning heads can be employed in the cleaning apparatus such as metal blades, meshes and brushes. The cleaning heads keep the rollers operational while minimizing deterioration of the roller.