Abstract: This invention relates generally to a system, device, and method for automated management of tension in tire chains and related traction improvement systems.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.

Abstract: A system and device for assisting users with stretching exercises comprised of a base, at least one stretch-assistance armature further comprised of at least one pylon, at least one motor, and at least one fastening means.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an ATXN2 gene, as well as methods of inhibiting expression of an ATXN2 gene and methods of treating subjects having an ATXN2-associated neurodegenerative disease or disorder, e.g., SCAs and ALS, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: This invention relates generally to a system, device, and method for automated management of tension in tire chains and related traction improvement systems.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: A tracking device and system are described where a location data collector device to receive location data of the tracking device and one or more communication devices that send the location data to a central facility and that receives a defined location package that includes location information where the tracking device is placed in either a suspension or active tracking mode.

Abstract: A vehicle power outlet switch (10) can include a threshold detector (14) for comparing a predetermined threshold with a vehicle battery characteristic and a power switch (18) controlled by the output of the threshold detector. Note, the vehicle battery characteristic differs while the vehicle engine is turned on or turned off and the threshold detector provides an enabling signal to the power switch when the vehicle engine is detected as being on. The threshold detector can also provide a disabling signal to the power switch when the vehicle engine is off. The power outlet switch can further include a timer (16) coupled to an output of the threshold detector that continues to provide an enabling signal to the power switch for a predetermined time after the threshold detector detects that the vehicle engine is turned off. The timer can include or be a one shot timer.

Abstract: A vehicle power outlet switch (10) can include a threshold detector (14) for comparing a predetermined threshold with a vehicle battery characteristic and a power switch (18) controlled by the output of the threshold detector. Note, the vehicle battery characteristic differs while the vehicle engine is turned on or turned off and the threshold detector provides an enabling signal to the power switch when the vehicle engine is detected as being on. The threshold detector can also provide a disabling signal to the power switch when the vehicle engine is off. The power outlet switch can further include a timer (16) coupled to an output of the threshold detector that continues to provide an enabling signal to the power switch for a predetermined time after the threshold detector detects that the vehicle engine is turned off. The timer can include or be a one shot timer.