Abstract: A retainer sleeve includes an at least partially annular body defining an axis of rotation, a radial direction, and a circumferential direction. The body may also have a radially inner annular surface defining a radially inner aperture, and a first anti-rotation feature extending radially inwardly from the radially inner annular surface including a sloping ledge having a locking surface that faces at least partially in the circumferential direction and along a direction that is parallel to the axis of rotation, forming an oblique angle with the direction that is parallel to the axis of rotation.

Abstract: A retainer sleeve includes an at least partially annular body defining an axis of rotation, a radial direction, and a circumferential direction. The body may also have a radially inner annular surface defining a radially inner aperture, and a first anti-rotation feature extending radially inwardly from the radially inner annular surface including a sloping ledge having a locking surface that faces at least partially in the circumferential direction and along a direction that is parallel to the axis of rotation, forming an oblique angle with the direction that is parallel to the axis of rotation.

Abstract: There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.

Abstract: A method for harvesting mushrooms which grow in clusters, by determining a picking schedule that maximises the yield while minimising damage to the mushroom or surrounding mushrooms to thereby increase shelf-life.

Abstract: A DS sensing apparatus includes a body and electrodes provided on the body. The body defines a test volume between a first surface and an opposing second surface spaced from the first surface a distance that allows a fluid to enter the test volume from a fluid inlet, which is communicatively coupled to the test volume, via capillary action. The electrodes include a first sensing electrode on the first surface and configured to receive an input RF signal, a second sensing electrode on the first surface spaced from the first sensing electrode and configured to deliver an output RF signal and a floating electrode on the second surface.

Abstract: The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Ring A, Ring B and Ring C have any of the meanings hereinbefore defined in the description; process for their preparation; pharmaceutical compositions containing them and their use in treating MCT4 mediated diseases.

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

Abstract: A portable DS device includes a device housing, device-side electrical contacts, a computing system and a removable sensor receiver assembly. The device housing includes a removable sensor receiver compartment. The device-side electrical contacts are positioned in or adjacent to the removable sensor receiver compartment. The computing system is in communication with the device-side electrical contacts and includes an impedance analyzer. The removable sensor receiver assembly includes a removable sensor receiver housing selectively receivable in and removable from the removable sensor receiver compartment. The removable sensor receiver housing includes a fluid sensing apparatus receiving section that receives a fluid sensing apparatus in which a fluid to be tested is loaded.

Abstract: A DS sensing apparatus includes a body and electrodes provided on the body. The body defines a test volume between a first surface and an opposing second surface spaced from the first surface a distance that allows a fluid to enter the test volume from a fluid inlet, which is communicatively coupled to the test volume, via capillary action. The electrodes include a first sensing electrode on the first surface and configured to receive an input RF signal, a second sensing electrode on the first surface spaced from the first sensing electrode and configured to deliver an output RF signal and a floating electrode on the second surface.

Abstract: A cutting edge tip includes an attachment portion defining an adapter receiving void. A working portion extends forwardly from the attachment portion. A first lateral end portion is disposed along the lateral direction, the first lateral end portion defining a first lateral end surface that jogs laterally. Also, a second lateral end portion is disposed along the lateral direction opposite of the first lateral end portion. The second lateral end portion also defines a second lateral end surface that jogs laterally.

Abstract: A wear member includes a forward working portion that is disposed along its longitudinal axis including a closed end, and a rear attachment portion that is disposed along the longitudinal axis including an open end with an exterior surface, and an interior surface. The interior surface defines an interior counterbore with a major diameter, and a minor diameter. A ratio of the major diameter to the minor diameter ranges from 1.8 to 2.2.

Abstract: A spring loaded retainer includes a lug receiving portion defining a first maximum outside dimension, the lug receiving portion also defining a lug receiving slot that extends partially through the lug receiving portion, forming a first sidewall, a second sidewall, and a catch surface connecting the first sidewall to the second sidewall. A drive portion defines a second maximum outside dimension, and a first flat is disposed on the outside of the lug receiving portion proximate to the first sidewall or the second sidewall.

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

Abstract: A wear member includes a forward working portion that is disposed along its longitudinal axis including a closed end, and a rear attachment portion that is disposed along the longitudinal axis including an open end with an exterior surface, and an interior surface. The interior surface defines an interior counterbore with a major diameter, and a minor diameter. A ratio of the major diameter to the minor diameter ranges from 1.8 to 2.2.

Abstract: A spring loaded retainer includes a lug receiving portion defining a first maximum outside dimension, the lug receiving portion also defining a lug receiving slot that extends partially through the lug receiving portion, forming a first sidewall, a second sidewall, and a catch surface connecting the first sidewall to the second sidewall. A drive portion defines a second maximum outside dimension, and a first flat is disposed on the outside of the lug receiving portion proximate to the first sidewall or the second sidewall.

Abstract: A retainer sleeve includes an at least partially annular body defining an axis of rotation, a radial direction, and a circumferential direction. The body may also have a radially inner annular surface defining a radially inner aperture, and a first anti-rotation feature extending radially inwardly from the radially inner annular surface including a sloping ledge having a locking surface, and an outer peripheral surface defining a notch that is at least partially aligned with the first anti-rotation feature or an array of a plurality of external ribs extending outwardly radially from the outer peripheral surface.

Abstract: The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Ring A, Ring B and Ring C have any of the meanings hereinbefore defined in the description; process for their preparation; pharmaceutical compositions containing them and their use in treating MCT4 mediated diseases.

Abstract: A retainer includes a drive portion defining a drive portion outer diameter, and a lug receiving portion with a skirt defining a lug receiving slot that extends partially through the lug receiving portion, forming a first sidewall, a second sidewall, and a catch surface connecting the first sidewall to the second sidewall. The skirt also defines a skirt outer diameter that is greater than the drive portion outer diameter. Also, the drive portion has a hook tab that extends from the drive portion and that is spaced away from the skirt a minimum distance.

Abstract: The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where A, Z, Y, RA, Linker and v have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof in methods of treatment of the human or animal body, for example in the prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

Abstract: A retainer sleeve includes an at least partially annular body defining an axis of rotation, a radial direction, and a circumferential direction. The body may also have a radially inner annular surface defining a radially inner aperture, and a first anti-rotation feature extending radially inwardly from the radially inner annular surface including a sloping ledge having a locking surface that faces at least partially in the circumferential direction and along a direction that is parallel to the axis of rotation, forming an oblique angle with the direction that is parallel to the axis of rotation.