Patents by Inventor Jason H. Bielas

Jason H. Bielas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20230193381
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: September 27, 2022
    Publication date: June 22, 2023
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20220349004
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: June 29, 2022
    Publication date: November 3, 2022
    Inventor: Jason H. BIELAS
  • Compositions and methods for accurately identifying mutations
    Patent number: 11441180
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: September 13, 2022
    Assignee: Fred Hutchinson Cancer Center
    Inventor: Jason H. Bielas
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210395818
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210388435
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210340619
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: July 13, 2021
    Publication date: November 4, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210317526
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 14, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210317525
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 14, 2021
    Inventor: Jason H. BIELAS
  • CELL POPULATION ANALYSIS USING SINGLE NUCLEOTIDE POLYMORPHISMS FROM SINGLE CELL TRANSCRIPTOMES
    Publication number: 20210277471
    Abstract: The disclosure provides methods and systems for producing single cell RNA sequencing data. Single nucleotide polymorphisms (SNPs) identified in such data can be used to distinguish subpopulations of cells within a mixed population.
    Type: Application
    Filed: September 23, 2020
    Publication date: September 9, 2021
    Inventors: Xinying Zheng, Jason H. Bielas, Mark T. Gregory, Benjamin Hindson, Tarjei Sigurd Mikkelsen, Ryan Wilson, Paul Ryvkin
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210246504
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 12, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210238678
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 5, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210238676
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 5, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210222243
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 22, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20210054455
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: November 6, 2020
    Publication date: February 25, 2021
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20200385804
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 10, 2020
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20200299766
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 24, 2020
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20200299767
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: June 10, 2020
    Publication date: September 24, 2020
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20200048706
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 13, 2020
    Inventor: Jason H. BIELAS
  • COMPOSITIONS AND METHODS FOR ACCURATELY IDENTIFYING MUTATIONS
    Publication number: 20200048707
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 13, 2020
    Inventor: Jason H. BIELAS
  • Compositions and methods for detecting rare nucleic acid molecule mutations
    Patent number: 10538807
    Abstract: The present disclosure relates to compositions and methods for detecting rare nucleic acid molecule mutations in a plurality of nucleic acid molecules. Also disclosed are methods for determining the size of a nucleic acid molecule using droplet digital PCR.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: January 21, 2020
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Jason H. Bielas, Sean D. Taylor, Matthew T. Laurie