Abstract: In a first embodiment, a ventilator has a housing with a first fixed port and a rotatable shutter configured to cooperate with the housing to enclose an interior of the housing. The shutter has a first orifice at a first radial distance from its axis of rotation. A stationary plate abuts the shutter and includes a first stationary orifice configured to at least partially align with the first orifice of the shutter over a first rotational distance of the shutter. In this way, the first orifice and the first stationary orifice form a first variable port. The stationary plate may have a second stationary orifice and the shutter may have a second orifice configured to at least partially align with the second stationary orifice over a second rotational distance of the shutter.

Abstract: A method for treatment of a tumor includes obtaining 3D imaging of the tumor; processing the 3D imaging of the tumor to obtain tumor morphology; determining a number of treatment sites, the locations of such sites, and the treatment dosage using a model of intratumoral treatment dynamics between vascular, intracellular, and extracellular space in order for the tumor to receive a therapeutic dosage at every location of the tumor; and treating the tumor at each of the determined treatment sites and with the determined treatment dosage. In some embodiments, the method further includes generating the model to include a plurality of interconnected volumes wherein each volume has one or more adjacent volumes with a shared boundary. One or more simulations of treatment over time may be conducted using the model, each simulation having a set of one or more initial parameters.

Abstract: Systems and methods for determining lung recruitment/derecruitment dynamics of an individual are disclosed. The disclosed embodiments advantageously use variable ventilation of the individual to determine lung dynamics without necessitating additional, potentially harmful ventilation maneuvers.

Abstract: Methods are presented for simulating drug movement within a model of a tumor that is mapped to the specific anatomy of the corresponding tumor in a patient as determined by imaging. With a segmentation of the tumor into distinct interconnected compartments and pre-determined initial parameters for the distributed tissue diffusivities and perfusion levels, the disclosed techniques can be used to predict the drug concentration throughout the tumor as a function of time, as well as the accumulation of drug in the rest of the body. In this way, advantageous initial parameters may be determined using the model. It is also possible to predict drug concentration throughout the tumor for a given intravenous injection of drug. Such a model serves an important role in treatment planning for lung tumors.

Abstract: Systems and methods for determining lung recruitment/derecruitment dynamics of an individual are disclosed. The disclosed embodiments advantageously use variable ventilation of the individual to determine lung dynamics without necessitating additional, potentially harmful ventilation maneuvers.

Abstract: A device and method for measuring the breathing of an individual being mechanically ventilated is presented, the device having a conduit configured as a Venturi tube with a gas flow path therethrough. Pressure transducers are located at positions in the gas flow path such that flow rate and/or other flow parameters may be determined.

Abstract: A system and method for measuring a pulmonary performance value of a subject. In one embodiment, a system includes one or more imaging devices, each configured to capture one or more images of a subject inside an interior chamber, such as a plethysmograph chamber. An exemplary system also includes an imaging processor in communication with the one or more imaging devices for estimating a change in volume of the subject from information about the one or more images.