Abstract: Systems and related methods for simultaneous high precision synchronization and syntonization of multiple sensors or clocks utilize a precision estimator that receives clock signals and time mark signals from both sensors (a reference sensor and a clock to be measured against the reference sensor). A precision time and frequency estimator determines a time offset, frequency offset, and phase offset of the measured sensor relative to the reference sensor. Associated systems can additionally determine the propagation delay between two remote subsystems connected by a communications channel. The communications channel may be a bidirectional duplexed or multiplexed channel allowing for mutual exchange of timing information along a single non-dedicated cable between sensors. Sensors may be synchronized to within 10 ps of each other without the need for THz clocks or fiber-optic cabling.