Patents by Inventor Jason HACKNEY

Jason HACKNEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors
    Patent number: 9873740
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: January 23, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane Grogan, Robert J. Johnston, Bryan Irving, Jason Hackney, Xin Yu, Dan Eaton, Kristin Bowles, Laetitia Comps-Agrar
  • METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND IL-17 BINDING ANTAGONISTS
    Publication number: 20170274073
    Abstract: The present disclosure provides methods comprising administering to the individual an effective amount of a PD-1 axis binding antagonist and an IL-17 binding antagonist. Further provided are kits comprising a PD-1 axis binding antagonist, an IL-17 binding antagonist, or both, as well as instructions for use thereof.
    Type: Application
    Filed: March 2, 2017
    Publication date: September 28, 2017
    Applicant: Genentech, Inc.
    Inventors: Jane GROGAN, Yuanyuan XIAO, Patrick CAPLAZI, Steve LIANOGLOU, Jason HACKNEY, Eugene Yu-Chuan CHIANG
  • METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20170233809
    Abstract: Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: September 21, 2016
    Publication date: August 17, 2017
    Applicant: Genentech, Inc.
    Inventors: Jason A. Hackney, Mary Keir, Gaik Wei Tew
  • NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20170145093
    Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: August 8, 2016
    Publication date: May 25, 2017
    Inventors: Hilary CLARK, Dan EATON, Lino GONZALEZ, JR., Jane GROGAN, Jason A. HACKNEY, Kristin BOWLES, Xin YU
  • METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS
    Publication number: 20170044256
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 16, 2017
    Inventors: Jane GROGAN, Robert J. JOHNSTON, Bryan IRVING, Jason HACKNEY, Xin YU, Dan EATON, Kristin BOWLES, Laetitia COMPS-AGRAR
  • METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS
    Publication number: 20170037127
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 9, 2017
    Inventors: Jane GROGAN, Robert J. JOHNSTON, Bryan IRVING, Jason HACKNEY, Xin YU, Dan EATON, Kristin BOWLES, Laetitia COMPS-AGRAR
  • Compositions and methods for the treatment of immune related diseases
    Patent number: 9499596
    Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: November 22, 2016
    Assignee: Genentech, Inc.
    Inventors: Hilary Clark, Dan Eaton, Lino Gonzalez, Jane Grogan, Jason Hackney, Kristin Bowles, Xin Yu
  • METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE
    Publication number: 20160178644
    Abstract: Biomarkers for diagnosing inflammatory bowel disease, including Crohn's disease, including fibrotic or fibrostenotic Crohn's disease, and ulcerative colitis and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease, including fibrotic or fibrostenotic Crohn's disease, are provided.
    Type: Application
    Filed: November 17, 2015
    Publication date: June 23, 2016
    Applicant: GENENTECH, INC.
    Inventors: Jason A. Hackney, Mary Keir, Lilyan Yi Tian Wright
  • METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS
    Publication number: 20150216970
    Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
    Type: Application
    Filed: July 16, 2014
    Publication date: August 6, 2015
    Inventors: Jane GROGAN, Robert J. JOHNSTON, Bryan IRVING, Jason HACKNEY, Xin YU, Dan EATON, Kristin BOWLES, Laetitia COMPS-AGRAR
  • NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20130251720
    Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: October 9, 2012
    Publication date: September 26, 2013
    Applicant: GENENTECH, INC.
    Inventors: HILARY CLARK, DAN EATON, LINO GONZALEZ, JR., JANE GROGAN, JASON A. HACKNEY, KRISTIN HARDEN, XIN YU
  • USE OF IL-27 ANTAGONISTS TO TREAT LUPUS
    Publication number: 20100297127
    Abstract: This invention relates to methods of treating the autoimmune disorder lupus with IL-27 antagonists, as well as articles of manufacture comprising IL-27 antagonists. The invention also relates to methods and kits for identifying patients that are likely to respond to an IL-27 antagonist treatment.
    Type: Application
    Filed: April 8, 2010
    Publication date: November 25, 2010
    Inventors: Nico P. GHILARDI, Marcel L. BATTEN, Jason A. HACKNEY
  • NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20090258013
    Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: April 8, 2009
    Publication date: October 15, 2009
    Applicant: Genentech, Inc.
    Inventors: Hilary Clark, Dan Eaton, Lino Gonzalez, JR., Jane Grogan, Jason A. Hackney, Kristin Harden, Xin YU