Abstract: A power control device 100 for an electrical load. The power control device 100 has an input 120 for receiving electrical power; an output 140 for supplying electrical power from the input to the electrical load; and a control module 160 for controlling the supply of electrical power to the electrical load from the output. The control module 160 is configured to define a plurality of discrete power-on timings, over a time period, during which electrical power is supplied from the output for powering the electrical load.

Abstract: Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is biparatopic or bispecific and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.

Abstract: Disclosed herein are antibodies or antigen binding fragments thereof that bind guanylyl cyclase C (GUCY2C), multi-specific antibodies comprising the same, and methods of treating cancer using the same.

Abstract: Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is monovalent and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.

Abstract: A molecule comprising a first means for engaging or activating a Natural Killer (NK) cell, and a second means for binding a tumor cell, wherein the molecule is capable of inducing NK cell dependent cytotoxicity against the tumor cell.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: A linear shaped charge includes a sheath having an open end and an opposite closed end. A peripheral wall extends longitudinally from an end wall a predetermined length. The peripheral wall has a first wall thickness and the end wall has a second wall thickness. The second wall thickness of the end wall is equal to or greater than the first wall thickness of the peripheral wall. The peripheral wall and the end wall cooperatively define a cavity. The linear shaped charge also includes an explosive material disposed within and substantially filling the cavity.

Abstract: A population of antibodies, wherein less than 80% of the oligosaccharides covalently attached to the population of the antibodies via N297 residues thereof comprise a core fucose residue; and wherein the population of the antibodies comprises an antibody which Fc region comprises K338A and T437R mutations, or K248E and T437R mutations.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: The present disclosure pertains to methods of capturing CO2 from an environment at pressures above 1 bar by associating the environment with a porous material that has a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm. The present disclosure also pertains to methods for the separation of CO2 from natural gas in an environment at partial pressures of either component above 1 bar by associating the environment with a porous material that has a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm.

Abstract: The present disclosure pertains to materials for CO2 adsorption at pressures above 1 bar, where the materials include a porous material with a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm as measured from N2 sorption isotherms using the BET (Brunauer-Emmett-Teller) method. The present disclosure also pertains to materials for separation of CO2 from natural gas at partial pressures of either component above 1 bar, where the materials include a porous material with a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm as measured from N2 sorption isotherms using the BET method.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: The present disclosure pertains to methods of capturing CO2 from an environment at pressures above 1 bar by associating the environment with a porous material that has a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm. The present disclosure also pertains to methods for the separation of CO2 from natural gas in an environment at partial pressures of either component above 1 bar by associating the environment with a porous material that has a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm.

Abstract: The present disclosure pertains to materials for CO2 adsorption at pressures above 1 bar, where the materials include a porous material with a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm as measured from N2 sorption isotherms using the BET (Brunauer-Emmett-Teller) method. The present disclosure also pertains to materials for separation of CO2 from natural gas at partial pressures of either component above 1 bar, where the materials include a porous material with a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm as measured from N2 sorption isotherms using the BET method.

Abstract: The present disclosure pertains to materials for CO2 adsorption at pressures above 1 bar, where the materials include a porous carbon material with a surface area of at least 2800 m2/g, a total pore volume of at least 1.35 cm3/g, and a carbon content of 80%-95%. The porous carbon material is prepared by heating organic polymer precursors or biological materials in the presence of KOH at 700° C.-800° C. The present disclosure also pertains to materials for the separation of CO2 from natural gas at partial pressures above 1 bar, where the material includes a porous carbon material with a surface area of at least 2000 m2/g, a total pore volume of at least 1.00 cm3/g, and a carbon content of greater than 90%. The porous carbon materials can be prepared by heating organic polymer precursors or biological materials in the presence of KOH at 600° C.-700° C.

Abstract: A facility for managing ownership of units of an item is described. The facility defines a commingling zone. For units of the item that are outside the commingling zone, the facility attributes ownership among a plurality of owners individually to each of the units. For units of the item that are inside the commingling zone, the facility attributes ownership among the plurality of owners to particular numbers of the units without attributing ownership individually to each of the units. The facility includes a method for reconciling ownership of units in the event of any discovered innacuracies.

Abstract: The conversion of linear polarized light into radial-polarized light is accomplished through a radial polarization generator containing multiple layers of polarizing film, or polarization converters, for converting the beam of light to a different orientation. Using the radial polarization generator, a quasi radial-polarized beam of light can be obtained quickly and easily by simply aligning the light at the center of the polarization generator. True radial-polarization can be obtained by passing the laser through a spatial filter. With such a radial polarization generator, a large frequency range of light may be converted from a linear orientation to a radial orientation.

Abstract: Methods and apparatus for converting linear polarized light into radial-polarized light are disclosed. The polarization is accomplished through a radial polarization generator containing multiple layers of polarizing film, or polarization converters, for converting the beam of light to a different orientation. Using the radial polarization generator, a quasi radial-polarized beam of light can be obtained quickly and easily by simply aligning the light at the center of the polarization generator. True radial-polarization can be obtained by passing the laser through a spatial filter. With such a radial polarization generator, a large frequency range of light may be converted from a linear orientation to a radial orientation.