Patents by Inventor JASON HOLDER

JASON HOLDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11407970
    Abstract: Systems and methods of testing a fluid sample are provided. A method can include controlling an orientation of a loader including a sample holder configured to hold a sample vessel to correspond to a first predetermined tilt angle. The method can include controlling an articulator to transfer the fluid sample from the sample vessel to at least one well of a plurality of wells of a multiwell plate positioned on a plate deck within the enclosure. The method can include controlling the articulator to move the multiwell plate to a hotel incubator within the enclosure. The method can include applying a bacteriophage to the fluid sample. The method can include controlling the articulator to move the multiwell plate from the hotel incubator to a testing system within the enclosure after a predetermined reaction time period. The method can include receiving output data from the testing system.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: August 9, 2022
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Parker Dow
  • Patent number: 11268072
    Abstract: The present disclosure provides compositions including recombinant K1E bacteriophages, methods for making the same, and uses thereof. The recombinant K1E bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 8, 2022
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Sarah Gruszka, Jason Holder
  • Patent number: 10900025
    Abstract: The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Patent number: 10815535
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 27, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings
  • Publication number: 20190367863
    Abstract: Systems and methods of testing a fluid sample are provided. A method can include controlling an orientation of a loader including a sample holder configured to hold a sample vessel to correspond to a first predetermined tilt angle. The method can include controlling an articulator to transfer the fluid sample from the sample vessel to at least one well of a plurality of wells of a multiwell plate positioned on a plate deck within the enclosure. The method can include controlling the articulator to move the multiwell plate to a hotel incubator within the enclosure. The method can include applying a bacteriophage to the fluid sample. The method can include controlling the articulator to move the multiwell plate from the hotel incubator to a testing system within the enclosure after a predetermined reaction time period. The method can include receiving output data from the testing system.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 5, 2019
    Inventors: Jason Holder, Parker Dow
  • Patent number: 10494638
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: December 3, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • Publication number: 20190330599
    Abstract: The present disclosure provides compositions including recombinant K1E bacteriophages, methods for making the same, and uses thereof. The recombinant K1E bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Sarah Gruszka, Jason Holder
  • Publication number: 20190309265
    Abstract: The present disclosure provides compositions including recombinant B 11 bacteriophages, methods for making the same, and uses thereof. The recombinant B 11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 10, 2019
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Patent number: 10329539
    Abstract: The present disclosure provides compositions including recombinant B11 bacteriophages, methods for making the same, and uses thereof. The recombinant B11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: June 25, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY INC.
    Inventors: Connor McBrine, Georgiana Kourepenos, Parker Dow, Jason Holder
  • Patent number: 10260083
    Abstract: The present disclosure provides compositions including recombinant K or 812 bacteriophages, methods for making the same, and uses thereof. The recombinant K or 812 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: April 16, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Peter Cavanagh, Helen Bartlett, Kirsty A. McFarland, Nicole E. Raustad, Sarah Gruszka, Jason Holder
  • Publication number: 20190078133
    Abstract: The present disclosure provides compositions and methods for identifying bacteria and profiling their antibiotic susceptibility. In particular, the methods and compositions of the present technology permit the detection of low concentrations of bacterial cells (e.g., <10 cells/ml) that are present within a complex biological sample.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 14, 2019
    Inventors: Peter Cavanagh, Quin Christensen, Kenneth T. Kotz, Jason Holder
  • Patent number: 10202610
    Abstract: The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 12, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Connor McBrine, Jason Holder
  • Patent number: 10174293
    Abstract: The present disclosure provides compositions including recombinant PB1 bacteriophages, methods for making the same, and uses thereof. The recombinant PB1 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 8, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Sarah Gruszka, Parker Dow, Jason Holder
  • Patent number: 10174294
    Abstract: The present disclosure provides compositions including recombinant K2 bacteriophages, methods for making the same, and uses thereof. The recombinant K2 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 8, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Connor McBrine, Georgiana Kourepenos, Jason Holder
  • Patent number: 10174295
    Abstract: The present disclosure provides compositions including recombinant K1E bacteriophages, methods for making the same, and uses thereof. The recombinant K1E bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 8, 2019
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Sarah Gruszka, Jason Holder
  • Publication number: 20180346905
    Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: May 31, 2018
    Publication date: December 6, 2018
    Inventors: Connor McBrine, Jason Holder
  • Publication number: 20180223262
    Abstract: The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 9, 2018
    Inventors: Connor McBrine, Jason Holder
  • Publication number: 20180223291
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 9, 2018
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • Publication number: 20170283779
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Application
    Filed: March 27, 2017
    Publication date: October 5, 2017
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: JASON HOLDER, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings