Abstract: An orthesis system includes an exoskeleton configured to be coupled to a user and a separate support device in the form of crutches, a walker or a cane. Preferably, the exoskeleton includes leg supports, an exoskeleton trunk, and actuators to provide for movement of the exoskeleton. The support device includes at least one support handle and a signal generator coupled to the support handle configured to generate and send a user command signal to an exoskeleton controller when activated by the user. The user command signal causes the exoskeleton controller to shift the exoskeleton between a first operational state and a second operational state. Optionally, a signal generator separate from the support device may be utilized to control the exoskeleton. Operational states of the exoskeleton include Walking, Standing, Seated, Sitting, Down and Standing Up states. User command signals can include a combination of distinct main, walking, or stopping signals.