Abstract: A catheter for ablating cardiac tissue through irreversible electroporation, the catheter comprises a tubular outer shaft and an electrode assembly extending distally from the distal end of the outer shaft. The electrode assembly defines a distally located central hub portion and a plurality of splines each extending proximally from the central hub portion. The electrode assembly comprises a flexible circuit having a flex circuit hub and a plurality of flex circuit branches integrally formed with and extending proximally from the flex circuit hub, the flexible circuit further including an outwardly-facing ablation electrode including an ablation electrode hub portion located on the flex circuit hub, and a plurality of ablation electrode branches integrally formed with the ablation electrode hub portion, each of the ablation electrode branches extending proximally along a portion of a respective one of the flex circuit branches and terminating in an ablation electrode proximal end.

Abstract: A flexible elongate member with the ability to deliver a material through a medium-delivery channel defined within a wall thereof. The flexible elongate member may have a tubular wall defining a lumen therethrough, the medium-delivery channel being formed within the tubular wall. The flexible elongate member may be a reinforced flexible tubular elongate member with a reinforcing layer within the tubular wall thereof. One or more filaments forming the reinforcing layer may be hollow to define the medium-delivery channel extending through the reinforced flexible tubular elongate member.

Abstract: Systems and methods for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a handle having a base having a distal end region and a proximal end region. A length adjustment member may be coupled to the handle. A length actuator may be coupled to the distal end region of the handle. A catheter shaft may be coupled to the handle. A steering mechanism may be coupled to the handle. The steering mechanism may include an elongate steering member having a first end region coupled to the handle, a first body region extending along the catheter shaft, a loop region extending about the catheter shaft, a second body region extending along the catheter shaft, and a second end region coupled to the handle.

Abstract: A delivery/deployment system for delivering an implantable device within an implantable device housing and for deploying the implantable device from the implantable device housing. A stylet may be used to longitudinally advance or retract the implantable device with respect to the implantable device housing, such as to extend and deploy the implantable device from the implantable device housing. The delivery/deployment system has an implantable-device-extension-limiter arrangement configured to limit the distance which the implantable device may be extended from the implantable device housing. The delivery/deployment system optionally also has an implantable-device-rotation-limiter arrangement configured to limit rotation of the implantable device with respect to the implantable device housing.

Abstract: A steerable device and system allowing a steerable elongate member positioned within another steerable tubular elongate member to be steered independently of the steerable tubular elongate member. The steerable tubular elongate member may be steered in a first plane, bending the steerable elongate member therein in the first plane as well. A steering mechanism operatively associated with the steerable elongate member has a distal portion operatively associated with a steerable region of the steerable elongate member to steer such steerable region within a second plane transverse to the first plane. The steering mechanism is independently movable with respect to a portion of the steerable elongate member proximal to the steerable region so as not to affect the orientation of the steerable region to be steered into a second plane transverse to the first plane.

Abstract: An elongate medical device is adapted to provide adjustable flexibility. The elongate medical device includes an inner coil having one or more inner coil filars extending in a first direction, and an outer coil having one or more outer filars extending in a second direction. A hypotube extends proximally from the inner coil and the outer coil. A cable extends through the inner coil and through the hypotube, where a distal end of the cable, a distal end of the inner coil and a distal end of the outer coil are all secured together at a distal end of the elongate medical device, such that applying a tensile force to the cable, relative to the hypotube, causes the inner coil and outer coil in combination to increase in stiffness.

Abstract: A steerable catheter includes a catheter shaft having a lumen defined by a catheter wall, a proximal portion, a distal portion, and a length extending therebetween, and at least one pullwire extending along the length of the catheter shaft and coupled to the catheter wall. The at least one pullwire has a proximal section extending along the proximal portion of the catheter shaft in a first radial position, a distal section extending along the distal portion of the catheter shaft in a second radial position, and a transition zone connecting the proximal section and the distal section. The second radial position is offset circumferentially from the first radial position.