Abstract: Systems and methods related to an orthopedic tensor for a knee joint. The tensor is motorized and operates in a force control mode and a displacement control mode. A control system controls the tensor in the force control mode to apply forces to the knee joint until a predetermined force is reached. The control system captures a plurality of force-displacement data pairs from the tensor as a result of the forces applied by the tensor in the force control mode. Control of the tensor is switched from the force control mode to the displacement control mode to perform an extension test whereby a displacement of the tensor is progressively decreased according to displacements from the plurality of force-displacement data pairs until the knee joint can reach an acceptable full extension pose during, or after completion of, the extension test.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: An operator for a global total order broadcast domain may send an operation out of band to nodes of participating parties, receive a certificate and a signature on an operation identifier for each participating node, generate a randomness vectors for each party participating in the operation, generate a random symmetric encryption key, encrypt the certificates, the signatures, and the randomness vector for each participating party with the symmetric encryption key, encrypt the symmetric encryption key under each public key for each participating party, and hash the symmetric encryption key, and recording, by the operator, the hashed symmetric encryption key on the global total order broadcast domain.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: Systems and methods of the present disclosure relate to force-balanced perforating tools that employ opposing non-perpendicular shaped charge orientations. A perforating tool includes at least two shaped charges positioned to fire in opposing directions, wherein each shaped charged is oriented at an angle that is not perpendicular to a longitudinal axis of the perforating tool.

Abstract: A surgical saw assembly that is adapted for cutting an anatomy. The surgical saw assembly includes a blade guard that supports a saw blade prevent deflection or skiving of the saw blade. The blade guard is rotatably moveable and has a front edge profile that interacts with a surface of the anatomy. The front edge profile has a geometry that is at least partially curved and/or follows a non-linear path of movement to provide a smooth interaction between the blade guard and the surface of the anatomy during rotational cuts that are not directly normal to the anatomical surface.

Abstract: Surgical systems and methods for use with a hand-guided tool. The surgical system includes a robotic manipulator that holds a tool guide. The tool guide receives and guides the surgical tool to enable the tool to manipulate a bone. The robotic manipulator autonomously aligns the tool guide to a target orientation relative to the bone. The tool guide is moved to an initial location adjacent to the bone while remaining aligned with the target orientation. The initial location is suitable for the tool to perform an initial manipulation of the bone. The robotic manipulator facilitates withdrawal of the tool guide away from the initial location to a spaced location after the initial manipulation of the bone while maintaining alignment of the tool guide with the target orientation at the spaced guide location. The spaced guide location is suitable for the tool to perform a further manipulation of the bone.

Abstract: Aspects of the disclosure may involve a method of generating resection plane data for use in planning an arthroplasty procedure on a patient bone. The method may include: obtaining patient data associated with at least a portion of the patient bone, the patient data captured using a medical imaging machine; generating a three-dimensional patient bone model from the patient data, the patient bone model including a polygonal surface mesh; identifying a location of a posterior point on the polygonal surface mesh; creating a three-dimensional shape centered at or near the location; identifying a most posterior vertex of all vertices of the polygonal surface mesh that may be enclosed by the three-dimensional shape; using the most posterior vertex as a factor for determining a posterior resection depth; and generating resection data using the posterior resection depth, the resection data configured to be utilized by a navigation system during the arthroplasty procedure.

Abstract: Provided herein are methods for improving working memory and/or executive function in a subject suffering from Parkinson's Disease, comprising administering to the subject a compound having the formula.

Abstract: Aspects of the disclosure may involve a method of generating resection plane data for use in planning an arthroplasty procedure on a patient bone. The method may include: obtaining patient data associated with at least a portion of the patient bone, the patient data captured using a medical imaging machine; generating a three-dimensional patient bone model from the patient data, the patient bone model including a polygonal surface mesh; identifying a location of a posterior point on the polygonal surface mesh; creating a three-dimensional shape centered at or near the location; identifying a most posterior vertex of all vertices of the polygonal surface mesh that may be enclosed by the three-dimensional shape; using the most posterior vertex as a factor for determining a posterior resection depth; and generating resection data using the posterior resection depth, the resection data configured to be utilized by a navigation system during the arthroplasty procedure.

Abstract: Surgical systems and methods for use with a hand-guided tool. The surgical system includes a robotic manipulator that holds a tool guide. The tool guide receives and guides the surgical tool to enable the tool to manipulate a bone. The robotic manipulator autonomously aligns the tool guide to a target orientation relative to the bone. The tool guide is moved to an initial location adjacent to the bone while remaining aligned with the target orientation. The initial location is suitable for the tool to perform an initial manipulation of the bone. The robotic manipulator facilitates withdrawal of the tool guide away from the initial location to a spaced location after the initial manipulation of the bone while maintaining alignment of the tool guide with the target orientation at the spaced guide location. The spaced guide location is suitable for the tool to perform a further manipulation of the bone.

Abstract: A system for landing a perforating gun in a particular orientation may include a landing housing securable within a wellbore and having at least one key slot extending into an inner surface of the landing housing. The system further includes a latch assembly configured to couple to the landing housing in a particular orientation. The latch assembly includes a tubular support structure and at least one key feature configured to extend and retract radially through a sidewall of the tubular support structure. The latch assembly further includes a biasing mechanism configured to bias the at least one key feature into the at least one key slot to couple the latch assembly to the landing housing. Additionally, the system includes a perforating gun system secured to the latch assembly such that the orientation of the latch assembly aims the perforating gun system in the wellbore.

Abstract: An operator for a global total order broadcast domain executing a method to send an operation out of band to nodes of participating parties in a partition, receive a certificate and a signature on the operation for each of the participating parties, generate a single party packet based on the received signatures, generate a random symmetric encryption key, send the random symmetric encryption key to the participating parties, encrypt the single party packet with the random symmetric encryption key, generate a pseudo random string for the partition, and record an operation identifier, the encrypted party packet, and the pseudo random string on the global total order broadcast domain.

Abstract: A system for landing a perforating gun in a particular orientation may include a landing housing securable within a wellbore and having at least one key slot extending into an inner surface of the landing housing. The system further includes a latch assembly configured to couple to the landing housing in a particular orientation. The latch assembly includes a tubular support structure and at least one key feature configured to extend and retract radially through a sidewall of the tubular support structure. The latch assembly further includes a biasing mechanism configured to bias the at least one key feature into the at least one key slot to couple the latch assembly to the landing housing. Additionally, the system includes a perforating gun system secured to the latch assembly such that the orientation of the latch assembly aims the perforating gun system in the wellbore.

Abstract: Systems, methods and computer-program products are provided for aiding in positioning between a surgical object and a machine vision camera in a surgical environment. The machine vision camera senses a position and orientation of a surgical object in its field of view. Controller(s) virtually define a zone within the field of view that indicates a range of acceptable positions for the surgical object relative to a position of the machine vision camera. The controller(s) obtain an acceptable orientation range for the surgical object relative to an orientation of the machine vision camera. The controller(s) execute a GUI to simultaneously present, on the display device, representations of: the field of view; the zone within the field of view; the position of the surgical object relative to the zone; and a current angle difference between the surgical object and the machine vision camera.

Abstract: A surgical system includes a tracking system configured to intraoperatively track relative positions of bones of a joint, a user interface configured to obtain a user input indicating a post-operative value for the joint, and a computer programmed to generate, based on the relative positions of the bones and the post-operative value, a planned orientation for an implant to be implanted in the joint, and to generate a surgical plan based on the planned orientation for the implant.

Abstract: A femoral prosthetic component includes a patellar guide portion, a pair of condyles projecting from the guide portion and forming an intercondylar notch therebetween, a bearing surface, and an interface surface configured to face a resected surface of a femur. The interface surface comprises an anterior face and a posterior face, and is substantially contoured between the anterior and posterior face to match a contoured surface of the femur. The substantially contoured interface surface may include at least one planar surface portion to about a flat cut portion in the surface of the femur. This planar surface portion may be a distal flat at a distal face of the interface surface. The contoured interface surface may alternatively include a plurality of planar surface portions. The femoral prosthetic component is configured such that preparation of the bone to match the interface surface results in minimal resection of the distal femur.

Abstract: Systems, methods and software are provided for aiding in positioning of objects in a surgical environment. A tracker is rigidly affixed to a surgical object. A camera has a field of view and senses positions of the tracker in the field of view. Controller(s) provide a zone positioned within the field of view at a location that is static relative to the field of view such that the zone is located independent of the sensed positions of the tracker. The zone defines a range of acceptable positions for the tracker relative to a position of the camera. Controller(s) acquire positions of the tracker as the surgical object is moved throughout a range of motion and enable evaluation of the positions of the tracker throughout the range of motion relative to the zone to aid in positioning of one or more of: the camera, the tracker, or the surgical object.

Abstract: A method includes obtaining a planned position of a first prosthetic component for implantation in a joint, obtaining positional data indicative of relative positions of bones of the joint, calculating, based on the positional data and the planned position of the first prosthetic component, a planned separation distance for the joint, facilitating adjustment of the planned position based on a desired separation distance by updating the planned separation distance in response to an adjusted planned position of the first prosthetic component, and guiding installation of the first prosthetic component in the joint in the adjusted planned position.

Abstract: A femoral prosthetic component includes a patellar guide portion, a pair of condyles projecting from the guide portion and forming an intercondylar notch therebetween, a bearing surface, and an interface surface configured to face a resected surface of a femur. The interface surface comprises an anterior face and a posterior face, and is substantially contoured between the anterior and posterior face to match a contoured surface of the femur. The substantially contoured interface surface may include at least one planar surface portion to about a flat cut portion in the surface of the femur. This planar surface portion may be a distal flat at a distal face of the interface surface. The contoured interface surface may alternatively include a plurality of planar surface portions. The femoral prosthetic component is configured such that preparation of the bone to match the interface surface results in minimal resection of the distal femur.