Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of the cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.

Abstract: A hair extension apparatus, comprising: a first base member comprising a first front edge, a first rear edge, a first side edge, a first top surface and a first bottom surface; a second base member comprising a second front edge, a second rear edge, a second side edge, a second top surface and a second bottom surface, wherein the second base member is coupled to the first base member; a first artificial hair section comprising artificial hair, wherein the first artificial hair section is coupled to the first top surface of the first base member; and a second artificial hair section comprising artificial hair, wherein the second artificial hair section is coupled to the second top surface of the second base member.

Abstract: A restraint system for a vehicle is disclosed. The restraint system includes a seat shaped to accommodate an occupant, wherein the seat includes a seat back and an energy absorption member that expands from a stowed position and into a deployed position. The energy absorption member fills a volume of space behind the seat back when in the deployed position to absorb energy that would otherwise be imparted towards an occupant of the seat during an impact involving the vehicle. The restraint system also includes an impact sensing device generating an impact signal in response to detecting the impact involving the vehicle is imminent. The impact signal indicates an orientation and magnitude of the impact involving the vehicle. The restraint system includes a control module in electronic communication with the energy absorption member and the impact sensing device.

Abstract: The present invention provides protease-cleavage resistant molecules comprising Shiga toxin effector polypeptides capable of exhibiting potent, Shiga toxin functions (e.g. subcellular routing and cytotoxicity). The present invention also provides protease-cleavage resistant, cell-targeting molecules for targeting specific cell types, e.g., infected or malignant cells. Certain molecules of the present invention are cytotoxic, and certain cell-targeting molecules of the present invention may be used for the targeted killing of specific cell types and the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections. Certain cell-targeting molecules of the invention exhibit improved, in vivo tolerability as compared to related cell-targeting molecules comprising protease-cleavage sensitive, wild-type, Shiga toxin effector polypeptides.

Abstract: A restraint system for a vehicle is disclosed. The restraint system includes a seat shaped to accommodate an occupant, wherein the seat includes a seat back and an energy absorption member that expands from a stowed position and into a deployed position. The energy absorption member fills a volume of space behind the seat back when in the deployed position to absorb energy that would otherwise be imparted towards an occupant of the seat during an impact involving the vehicle. The restraint system also includes an impact sensing device generating an impact signal in response to detecting the impact involving the vehicle is imminent. The impact signal indicates an orientation and magnitude of the impact involving the vehicle. The restraint system includes a control module in electronic communication with the energy absorption member and the impact sensing device.

Abstract: The present invention provides protease-cleavage resistant molecules comprising Shiga toxin effector polypeptides capable of exhibiting potent, Shiga toxin functions (e.g. subcellular routing and cytotoxicity). The present invention also provides protease-cleavage resistant, cell-targeting molecules for targeting specific cell types, e.g., infected or malignant cells. Certain molecules of the present invention are cytotoxic, and certain cell-targeting molecules of the present invention may be used for the targeted killing of specific cell types and the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections. Certain cell-targeting molecules of the invention exhibit improved, in vivo tolerability as compared to related cell-targeted molecules comprising protease-cleavage sensitive, wild-type, Shiga toxin effector polypeptides.

Abstract: A server computer receives configuration data from a first user of a first user device and establishes an interaction limit for the first user based on the configuration data. The server computer subsequently receives a request message from a second user device of a second user that includes parameters, including a request for services. The server computer selects the first user from a plurality of users based on the parameters and the configuration data from the first user. The server computer transmits a quote message to the second user device indicating the selection of the first user and including a quote. When the server computer receives an indication of a response message from the second user device, the server computer processes the response message and determines if the response message is indicative of an interaction type that requires modifying a first user account associated with the first user.

Abstract: A hair extension apparatus, comprising: a first base member comprising a first front edge, a first rear edge, a first side edge, a first top surface and a first bottom surface; a second base member comprising a second front edge, a second rear edge, a second side edge, a second top surface and a second bottom surface, wherein the second base member is coupled to the first base member; a first artificial hair section comprising artificial hair, wherein the first artificial hair section is coupled to the first top surface of the first base member; and a second artificial hair section comprising artificial hair, wherein the second artificial hair section is coupled to the second top surface of the second base member.

Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.

Abstract: The present invention provides CD20-binding proteins that bind to and rapidly internalize CD20 antigens from a cell surface location to the interior of a cell. CD20-binding proteins of the invention comprise a CD20 binding region and a Shiga toxin effector region. Certain of the disclosed CD20-binding proteins kill cells that express CD20 on their surface. Further, the presently disclosed CD20-binding proteins can comprise additional exogenous materials and are capable of targeted delivery of these additional exogenous materials into the interior of CD20 expressing cells. Such additional materials may include peptides, antigens, enzymes, and polynucleotides. These CD20-binding proteins have uses in methods of internalizing themselves, targeted killing of CD20 expressing cells, delivering exogenous materials into CD20 expressing cells, and treating a variety of diseases involving CD20 expressing cells, such as cancers and immune disorders.

Abstract: The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the interim reduction or elimination of ribotoxicity and the methods can identify cytotoxic molecules, each comprising a binding region and a ribotoxic region which jointly possess a desired assay-selectable characteristic, such as, e.g., binding to a target biomolecule, binding to a target cell, and/or cellular internalization.

Abstract: The present invention provides multivalent CD20-binding molecules and compositions thereof, such as enriched compositions comprising large proportions of multivalent CD20-binding molecules relative to monovalent CD20-binding molecules. Certain multivalent CD20-binding molecules of the present invention comprise (i) two or more CD20-binding regions and (ii) one or more Shiga toxin effector polypeptide regions derived from an A Subunit of a member of the Shiga toxin family. Certain multivalent CD20-binding molecules of the present invention, and compositions thereof, have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, tumors, and immune disorders.

Abstract: The present invention provides CD20-binding proteins that bind to and rapidly internalize CD20 antigens from a cell surface location to the interior of a cell. CD20-binding proteins of the invention comprise a CD20 binding region and a Shiga toxin effector region. Certain of the disclosed CD20-binding proteins kill cells that express CD20 on their surface. Further, the presently disclosed CD20-binding proteins can comprise additional exogenous materials and are capable of targeted delivery of these additional exogenous materials into the interior of CD20 expressing cells. Such additional materials may include peptides, antigens, enzymes, and polynucleotides. These CD20-binding proteins have uses in methods of internalizing themselves, targeted killing of CD20 expressing cells, delivering exogenous materials into CD20 expressing cells, and treating a variety of diseases involving CD20 expressing cells, such as cancers and immune disorders.

Abstract: The present invention relates to methods of screening libraries of chimeric molecules comprising ribotoxic polypeptides, where screening is based on the interim reduction or elimination of ribotoxicity and the methods can identify cytotoxic molecules, each comprising a binding region and a ribotoxic region which jointly possess a desired assay-selectable characteristic, such as, e.g., binding to a target biomolecule, binding to a target cell, and/or cellular internalization.

Abstract: A hair apparatus, comprising: a cap layer cap layer configured to fit around a circumference of a user's head; at least one lace part disposed in a front portion of the cap; and a plurality of hair combs attached in a bottom or side part, to the inside surface of the cap layer.

Abstract: The present invention provides multivalent CD20-binding molecules, and compositions thereof, such as enriched compositions comprising large proportions of multivalent CD20-binding molecule relative to monovalent CD20-binding molecule. Certain multivalent CD20-binding molecules of the present invention comprise 1) two or more CD20 binding regions and 2) one or more Shiga toxin effector polypeptide regions derived from an A Subunit of a member of the Shiga toxin family. Certain multivalent CD20-binding molecules of the present invention, and compositions thereof, have uses for selective killing specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, tumors, and immune disorders.

Abstract: An interchangeable hair extension system. The system comprises: an anterior hair extension member comprising an anterior mesh base, wherein the anterior mesh base comprises an anterior inner surface, an anterior outer surface, and an anterior edge; a posterior hair extension member removably coupled to the anterior hair extension member, the posterior hair extension member comprising a posterior mesh base, wherein the posterior mesh base comprises a posterior inner surface, a posterior outer surface, and a posterior edge; artificial hair coupled to each of the anterior outer surface and to the posterior outer surface.

Abstract: A wig apparatus comprises: a front mesh section comprising a first material; a rear mesh section comprising a second material; a seam extending from one side of the wig apparatus to the opposite side of the wig apparatus, wherein the first material and second material are coupled together along the seam and wherein the first material and second material at least partially overlap along the seam; a parting area disposed within the front section comprising a first parting area layer, a second parting area layer and a third parting area layer; and artificial hair coupled to the front section, the rear section and the parting area.

Abstract: A multi-modal type wearable user authentication apparatus includes a housing; an electrode plate disposed at a rear surface of the housing to contact a user wrist; a display panel disposed at a front surface of the housing; and a multi-modal type user authentication sensor including mutually separated first and second electrodes disposed at the lower end of the display panel and constituting an edge and a bio recognition module disposed at the center.

Abstract: A multi-modal based user authentication apparatus and method are provided. The multi-modal based user authentication apparatus includes a memory that stores whether user authentication is succeeded or failed; a processor that determines whether user authentication is succeeded or failed through user authentication; and a user authentication sensor unit that performs step (a) of measuring user bio signal information through a bio signal measurement sensor, step (b) of acquiring user bio recognition information through a bio recognition acquisition sensor, and step (c) of performing the user authentication by analyzing a correlation between the bio signal information and the bio recognition information.