Abstract: A method comprises measuring a first physico-chemical property of analyte ions so as to produce a data set, and identifying a first group of analyte ions within the data set. Analyte ions within the first group each have a value of an attribute that corresponds to a first value or that is within a first range of the attribute. The method further comprises selecting, from a plurality of different calibrations, a first calibration associated with the first value or first range of the attribute, and calibrating the measured first physico-chemical property of the first group of analyte ions using the first calibration.

Abstract: Disclosed herein is a bench-top time of flight mass spectrometer. In embodiments, there is provided a solvent bottle mounting assembly configured so that a user can press a solvent bottle onto the solvent bottle mounting assembly in order to mount the solvent bottle to the mass spectrometer. Other embodiments relate to a vacuum arrangement comprising first and second vacuum chambers with respective first and second vacuum pumps wherein a backing line for the second vacuum pump is connected to the first vacuum chamber such that the second vacuum pump is backed to the first vacuum chamber. Also disclosed in a method of manufacturing a lens plate or electrode wherein a substrate is chemically etched to reduce a sharp cusp to provide a smoother edge profile.

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.