Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: receiving a resource request by at least one processor in the distributed resource management system, the resource request identifying a requested resource type corresponding to at least one of: a class identifier identifying a resource class assigned to a composite resource, and a class identifier identifying at least one additional resource associated with the composite resource; determining availability of the requested resource type; and scheduling a workload associated with the resource request for execution based on the determination.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: receiving a resource request by at least one processor in the distributed resource management system, the resource request identifying a requested resource type corresponding to at least one of: a class identifier identifying a resource class assigned to a composite resource, and a class identifier identifying at least one additional resource associated with the composite resource; determining availability of the requested resource type; and scheduling a workload associated with the resource request for execution based on the determination.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: receiving a resource request by at least one processor in the distributed resource management system, the resource request identifying a requested resource type corresponding to at least one of: a class identifier identifying a resource class assigned to a composite resource, and a class identifier identifying at least one additional resource associated with the composite resource; determining availability of the requested resource type; and scheduling a workload associated with the resource request for execution based on the determination.

Abstract: In some aspects, control circuitry may receive a selection of a foreground object presented in a video scene being viewed by the user. Based on the selection of the foreground object, control circuitry may ascertain a background object from the video scene. By ascertaining an object, control circuitry may be able to identify an object, and prepare for modification a design file for the 3D printing of that object. Control circuitry may determine an attribute of the foreground object. Based on the determined foreground object attribute, control circuitry may modify a parameter of a design file for printing a 3D printing of the background object.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: receiving a resource request by at least one processor in the distributed resource management system, the resource request identifying a requested resource type corresponding to at least one of: a class identifier identifying a resource class assigned to a composite resource, and a class identifier identifying at least one additional resource associated with the composite resource; determining availability of the requested resource type; and scheduling a workload associated with the resource request for execution based on the determination.

Abstract: In some aspects, control circuitry may receive a selection of a foreground object presented in a video scene being viewed by the user. Based on the selection of the foreground object, control circuitry may ascertain a background object from the video scene. By ascertaining an object, control circuitry may be able to identify an object, and prepare for modification a design file for the 3D printing of that object. Control circuitry may determine an attribute of the foreground object. Based on the determined foreground object attribute, control circuitry may modify a parameter of a design file for printing a 3D printing of the background object.

Abstract: There is described herein an online lottery application providing single play and group play in a structured and clear manner. Group play is designed to set out playing and winning conditions such that all members of the group are aware of them and adhere to them. Ticket checking and validation for group play is simplified and facilitated by the online lottery application.

Abstract: There is described herein an interactive game having both lotterized and skill-based wagering aspects embedded therein. A skill-based game is used to provide players with the challenge and entertainment value that they are accustomed to experiencing in popular mobile games, while adding the possibility of collecting real world winnings via lotteries and other forms of wagering.

Abstract: There is an interactive video game having a lotterized aspect incorporated therein. In addition to the traditional interactive video game, instant and future win opportunities are presented to the player throughout the game. The game and win opportunities are played with a plurality of virtual currencies, the virtual currencies comprising credits for purchasing virtual goods in the game play instance, tokens applicable within the game play instance for participating in the real world lottery, and gifts representative of virtual goods exchangeable between players.

Abstract: A system for executing a lotterized video game comprises at least one computer server communicable with at least one client computing device over a network. The server has a processor and a memory with program modules stored thereon and executable by the server. The program modules comprise a game engine module having program code that when executed, generates an interactive game play instance playable on the client computing device; and a lottery services module having program code that when executed, conducts a real lottery transaction within the game play instance.

Abstract: There is described herein an interactive game having both lotterized and skill-based wagering aspects embedded therein. A skill-based game is used to provide players with the challenge and entertainment value that they are accustomed to experiencing in popular mobile games, while adding the possibility of collecting real world winnings via lotteries and other forms of wagering.

Abstract: There is an interactive video game having a lotterized aspect incorporated therein. In addition to the traditional interactive video game, instant and future win opportunities are presented to the player throughout the game. The game and win opportunities are played with a plurality of virtual currencies, the virtual currencies comprising credits for purchasing virtual goods in the game play instance, tokens applicable within the game play instance for participating in the real world lottery, and gifts representative of virtual goods exchangeable between players.

Abstract: Systems and methods for scheduling jobs in a networked computing grid having job service components for creating jobs having certain resource requirements are described. One embodiment includes resource manager components communicatively linked with the job service components, each resource manager component being configured to manage a plurality of resources. Such a system further includes information components communicatively linked with the job service components and the resource manager components, the information components being configured to aggregate resource data obtained from the resource manager components. The jobs include a scheduling mechanism for querying the information components for resource data, comparing the resource data against the resource requirements and independently scheduling the job to the resource manager components. A resource reservation is also provided for reserving resources for the jobs.

Abstract: A system for scheduling jobs in a networked computing grid having one or more job service components for creating one or more jobs having certain resource requirements is described. The system includes a plurality of resource manager components communicatively linked with the one or more job service components, each resource manager component being configured to manage a plurality of resources. The system further includes one or more information components communicatively linked with the one or more job service components and the plurality of resource manager components, the one or more information components being configured to aggregate resource data obtained from the resource manager components. The one or more jobs include a scheduling mechanism for querying the one or more information components for resource data, comparing the resource data against the resource requirements and independently scheduling the job to one or more of the plurality of resource manager components.