Abstract: In some examples, a medical device includes a flexible elongate member configured for navigation through vasculature of a patient to a target treatment site. A distal portion of the elongate member including a first balloon portion that is inflatable to an expanded state, a second balloon portion that is inflatable to an expanded state, and a cavitation generator. When the balloon portions are in their expanded states within the vasculature, a cavity is defined between the elongate member and the target treatment site and exterior to the first and second balloon portions. The cavitation generator is configured to deliver energy to a fluid within the cavity to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Abstract: In some examples, a medical device includes a flexible elongate member configured for navigation through vasculature of a patient to a target treatment site. A distal portion of the elongate member including a first balloon portion that is inflatable to an expanded state, a second balloon portion that is inflatable to an expanded state, and a cavitation generator. When the balloon portions are in their expanded states within the vasculature, a cavity is defined between the elongate member and the target treatment site and exterior to the first and second balloon portions. The cavitation generator is configured to deliver energy to a fluid within the cavity to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Abstract: Catheters having spiral electrodes and methods for their use in neuromodulation therapy. A therapeutic assembly is disposed at a distal portion of a neuromodulation catheter and is adapted to be located at a target location within a target blood vessel of a human patient. The therapeutic assembly can include at least two shape-memory metallic elements that extend in parallel along the distal portion, each metallic element having an exposed surface to serve as an electrode. The shape memory of the metallic elements transforms the therapeutic assembly between a low-profile delivery configuration and a deployed radially-expanded spiral configuration. A dielectric material attaches the metallic elements to each other while maintaining physical separation and electrical isolation from each other along at least the distal portion.

Abstract: A cleaning device for cleaning a catheter lumen of a tissue removal catheter has a flushing chamber with distal and proximal seals and an inlet port. The proximal seal is a duckbill seal that includes a pair of opposing duckbill members that slidingly accept the distal end portion of a catheter body to form a seal about the catheter body proximal to a proximal opening in of the catheter lumen. Fluid is directed in the inlet port, into the flushing chamber, into proximal opening in the catheter body, and through the catheter lumen to discharge tissue contained in the catheter lumen. In some embodiments, the cleaning device is preloaded on the catheter body. The cleaning device can have an internal stop that engages with an external stop on the catheter body when the cleaning device is positioned in an operative position.