Abstract: RhoA inhibitors that can covalently bind RhoA are described herein. The disclosed RhoA inhibitors show improved inhibitory efficacy (i.e., an IC50 value down to about 400 nM). Further, the disclosed RhoA inhibitors can specifically bind RhoA over other GTPases, such as other Ras GTPases (e.g., K-Ras and N-Ras) and particularly other Rho GTPases (e.g., Cdc42 and Rac1). The combination of high RhoA inhibitory efficacy and high RhoA specificity of the disclosed RhoA inhibitors allow these compounds to show high cytotoxicity and anti-metastatic effects in cancer cells, with negligible toxicity in normal cells, in vitro and in vivo. Pharmaceutical compositions containing the RhoA inhibitors and methods of using the RhoA inhibitors or pharmaceutical composition thereof for treating cancer are also described.

Abstract: A method includes updating, in a server, a workflow in a contract based on an action by a remote user. The method also includes storing an updated version of the contract in a directory, and providing, to an approver remotely coupled with the server, a link to the updated version. Updating the workflow includes at least one of: selecting a governing law or any other type of field or constraint controlling the updated version of the contract, adding a conditional variable to the contract, the conditional variable configured to acquire a value based on an input from the remote user, or the approver, adding or removing a portion of the contract based on a value of the conditional variable in the contract, and modifying a role for the approver. A system and a non-transitory, computer-readable medium storing instructions to perform the above method are also disclosed.

Abstract: Aspects of the disclosure relate to event processing. A computing platform may prefetch, prior to receipt of a purchase request, a plurality of pay to addresses (associated with an omnibus account, used to route funds from the omnibus account to a merchant account, and not associated with a particular merchant account when prefetched). The computing platform may receive, from a client, a request to make a purchase from a merchant, and may associate the client and the merchant with one of the prefetched pay to addresses/notify the client of the prefetched pay to address. The computing platform may monitor the prefetched pay to address for receipt of a predefined amount of cryptocurrency associated with the purchase. Upon detecting receipt of the predefined amount of cryptocurrency, the computing platform may transfer funds corresponding to the purchase from the omnibus account to an account for the merchant.

Abstract: A method includes updating, in a server, a workflow in a contract based on an action by a remote user. The method also includes storing an updated version of the contract in a directory, and providing, to an approver remotely coupled with the server, a link to the updated version. Updating the workflow includes at least one of: selecting a governing law or any other type of field or constraint controlling the updated version of the contract, —adding a conditional variable to the contract, the conditional variable configured to acquire a value based on an input from the remote user, or the approver, adding or removing a portion of the contract based on a value of the conditional variable in the contract, and modifying a role for the approver. A system and a non-transitory, computer-readable medium storing instructions to perform the above method are also disclosed.

Abstract: Aspects of the disclosure relate to event processing. A computing platform may prefetch, prior to receipt of a purchase request, a plurality of pay to addresses (associated with an omnibus account, used to route funds from the omnibus account to a merchant account, and not associated with a particular merchant account when prefetched). The computing platform may receive, from a client, a request to make a purchase from a merchant, and may associate the client and the merchant with one of the prefetched pay to addresses/notify the client of the prefetched pay to address. The computing platform may monitor the prefetched pay to address for receipt of a predefined amount of cryptocurrency associated with the purchase. Upon detecting receipt of the predefined amount of cryptocurrency, the computing platform may transfer funds corresponding to the purchase from the omnibus account to an account for the merchant.

Abstract: A method for determining a wavefront parameter of a patterning process. The method includes obtaining a reference performance (e.g., a contour, EPE, CD) of a reference apparatus (e.g., a scanner), a lens model for a patterning apparatus configured to convert a wavefront parameter of a wavefront to actuator movement, and a lens fingerprint of a tuning apparatus (e.g., a to-be-matched scanner). Further, the method involves determining the wavefront parameter (e.g., a wavefront parameter such as tilt, offset, etc.) based on the lens fingerprint of the tuning apparatus, the lens model, and a cost function, wherein the cost function is a difference between the reference performance and a tuning apparatus performance.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for detecting changes to uploaded documents in a workflow platform. Various aspects may include determining changes between various versions of a media file. Aspects may include detecting what portions of the media file change relative to different instances of the various media file versions. Aspects may also include updating a template element to incorporate the changes to the portions of the media file so that the template element may be used to regenerate a new version of the media file with the incorporated changes being reflected by the template element. Aspects may include determining a new location of text within a portion of the media file that is changed between versions of the media file.

Abstract: A method includes receiving, in a first networking platform, an electronic message directed from a first party to a workflow to a second party of the workflow. The method also includes identifying a document attached to the electronic message as relevant to the workflow, and identifying at least a portion of a text content in the electronic message as relevant to the workflow. The method also includes updating the workflow associated with the workflow based on the document attached to the electronic message, when the second party provides the input and storing the document attached to the electronic message in a database, as a new version of the workflow. A system and a non-transitory, computer-readable medium storing instructions to perform the above method are also provided.

Abstract: A social network content recommendation system allows users to identify friends, recommend content to friends, and receive awards for influencing friends. Internet pages can be used to display rankings of recommended programs, user profiles and their awards, and dynamic chats relating to specific programs, such as television shows.

Abstract: A method for optimizing a patterning device pattern, the method including obtaining an initial design pattern having a plurality of polygons, causing at least some of the polygons to be effectively connected with each other, placing evaluation features outside the boundaries of the polygons, and creating a patterning device pattern spanning across the connected polygons based on the evaluation features.

Abstract: A method for determining a wavefront parameter of a patterning process. The method includes obtaining a reference performance (e.g., a contour, EPE, CD) of a reference apparatus (e.g., a scanner), a lens model for a patterning apparatus configured to convert a wavefront parameter of a wavefront to actuator movement, and a lens fingerprint of a tuning apparatus (e.g., a to-be-matched scanner). Further, the method involves determining the wavefront parameter (e.g., a wavefront parameter such as tilt, offset, etc.) based on the lens fingerprint of the tuning apparatus, the lens model, and a cost function, wherein the cost function is a difference between the reference performance and a tuning apparatus performance.

Abstract: Aspects of the disclosure relate to event processing. A computing platform may prefetch, prior to receipt of a purchase request, a plurality of pay to addresses (associated with an omnibus account, used to route funds from the omnibus account to a merchant account, and not associated with a particular merchant account when prefetched). The computing platform may receive, from a client, a request to make a purchase from a merchant, and may associate the client and the merchant with one of the prefetched pay to addresses/notify the client of the prefetched pay to address. The computing platform may monitor the prefetched pay to address for receipt of a predefined amount of cryptocurrency associated with the purchase. Upon detecting receipt of the predefined amount of cryptocurrency, the computing platform may transfer funds corresponding to the purchase from the omnibus account to an account for the merchant.

Abstract: A method for determining a wavefront parameter of a patterning process. The method includes obtaining a reference performance (e.g., a contour, EPE, CD) of a reference apparatus (e.g., a scanner), a lens model for a patterning apparatus configured to convert a wavefront parameter of a wavefront to actuator movement, and a lens fingerprint of a tuning apparatus (e.g., a to-be-matched scanner). Further, the method involves determining the wavefront parameter (e.g., a wavefront parameter such as tilt, offset, etc.) based on the lens fingerprint of the tuning apparatus, the lens model, and a cost function, wherein the cost function is a difference between the reference performance and a tuning apparatus performance.

Abstract: A social network content recommendation system allows users to identify friends, recommend content to friends, and receive awards for influencing friends. Internet pages can be used to display rankings of recommended programs, user profiles and their awards, and dynamic chats relating to specific programs, such as television shows.

Abstract: In an embodiment, a method comprises: generating a user interface configured to allow selecting a product from a plurality of products that are customizable and displaying the user interface on a display device of a user computer; receiving, via the user interface, a selection of a particular product, from the plurality of products, that require customization; in response to receiving the selection of the particular product, automatically generating a plurality of customization options available for customizing the particular product; receiving one or more triggers of a plurality of triggers, generated based on customization options selected from the plurality of customization options; automatically generating one or more corresponding customization attribute values for the particular product; automatically generating one or more digital representations of the particular product, and displaying the digital representations of the particular product on the display device of the user computer.

Abstract: A light engine comprising a substantially tubular substrate including base portion with a plurality of slots, a first group of at least two filament LEDs on a first portion of the substantially tubular substrate, and a second group of at least two filament LEDs on a second portion of the substantially tubular substrate. Each of the first and second groups of the at least two filament LEDs being electrically connected through a base electrode to electrode contacts in the slots. The light engine also includes an electrical bus wire present proximate to the end of the substantially tubular substrate that is opposite the end at the base portion of the substantially tubular substrate, the electrical bus wire in contact with each filament LED for each of the first and second groups of at least two filament LEDs.

Abstract: A composition for preventing or treating hypoglycemia in a patient in need thereof has a microgel that includes crosslinked polymers containing glucose-responsive moieties; and blood glucose-raising therapeutic agent loaded on or within the microgel. The microgel further includes any one or a combination of a stabilizing component and a loading-assisting component for the blood glucose- raising therapeutic agent. The polymers containing the glucose-responsive moieties form secondary crosslinks in response to low glucose level, thereby causing shrinking of the microgel and rapid release of the blood glucose-raising therapeutic agent. The composition can be used to prepare a composite microneedle patch for preventing or treating hypoglycemia, where the composition is embedded or integrated within an array of the microneedles of the microneedle patch device.

Abstract: A method for determining a wavefront parameter of a patterning process. The method includes obtaining a reference performance (e.g., a contour, EPE, CD) of a reference apparatus (e.g., a scanner), a lens model for a patterning apparatus configured to convert a wavefront parameter of a wavefront to actuator movement, and a lens fingerprint of a tuning apparatus (e.g., a to-be-matched scanner). Further, the method involves determining the wavefront parameter (e.g., a wavefront parameter such as tilt, offset, etc.) based on the lens fingerprint of the tuning apparatus, the lens model, and a cost function, wherein the cost function is a difference between the reference performance and a tuning apparatus performance.